Novel benzimidazole-pyrimidine conjugates as potent antitumor agents

European Journal of Medicinal Chemistry

Volumn 45, Issue 6, 2010, Pages 2336-2344

  Abdel Mohsen, Heba T ^a   Ragab, Fatma A F ^b   Ramla, Mostafa M ^a   El Diwani, Hoda I ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

Author keywords

Antitumor activity; Benzimidazole; Pyrimidine; Synthesis

Indexed keywords

1 [2 [(1H BENZO[D]IMIDAZOL 2 YL)METHYLTHIO] 5 CYANO 6 PHENYLPYRIMIDIN 4 YL]THIOSEMICARBAZIDE; 1 [2 [(1H BENZO[D]IMIDAZOL 2 YL)METHYLTHIO] 5 CYANO 6 PHENYLPYRIMIDIN 4 YL]THIOUREA; 1 [2 [(1H BENZO[D]IMIDAZOL 2 YL)METHYLTHIO] 5 CYANO 6 PHENYLPYRIMIDIN 4 YL]UREA; 2 [(1H BENZO[D]IMIDAZOL 2 YL)METHYLTHIO) 4 PHENYL 6 (THIAZOL 2 YLAMINO)PYRIMIDINE 5 CARBONITRILE; 2 [(1H BENZO[D]IMIDAZOL 2 YL)METHYLTHIO] 1,6 DIHYDRO 6 OXO 4 PHENYLPYRIMIDINE 5 CARBONITRILE; 2 [(1H BENZO[D]IMIDAZOL 2 YL)METHYLTHIO] 4 (2 PHENYLHYDRAZINYL) 6 PHENYL PYRIMIDINE 5 CARBONITRILE; 2 [(1H BENZO[D]IMIDAZOL 2 YL)METHYLTHIO] 4 (4 BENZOYLPIPERAZIN 1 YL) 6 PHENYLPYRIMIDINE 5 CARBONITRILE; 2 [(1H BENZO[D]IMIDAZOL 2 YL)METHYLTHIO] 4 (METHYLPIPERAZIN 1 YL) 6 PHENYLPYRIMIDINE 5 CARBONITRILE; 2 [(1H BENZO[D]IMIDAZOL 2 YL)METHYLTHIO] 4 [4 (2 NITROBENZENSULPHONYL)PIPERAZIN 1 YL] 6 PHENYLPYRIMIDINE 5 CARBONITRILE; 2 [(1H BENZO[D]IMIDAZOL 2 YL)METHYLTHIO] 4 [4 (4 NITROBENZOYL) PIPERAZIN 1 YL] 6 PHENYLPYRIMIDINE 5 CARBONITRILE; 2 [(1H BENZO[D]IMIDAZOL 2 YL)METHYLTHIO] 4 CHLORO 6 PHENYLPYRIMIDINE 5 CARBONITRILE; 2 [(1H BENZO[D]IMIDAZOL 2 YL)METHYLTHIO] 4 HYDRAZINYL 6 PHENYLPYRIMIDINE 5 CARBONITRILE; 2 [(1H BENZO[D]IMIDAZOL 2 YL)METHYLTHIO] 4 PHENYL 6 (4 TOSYLPIPERAZIN 1 YL)PYRIMIDINE 5 CARBONITRILE; 2 [(1H BENZO[D]IMIDAZOL 2 YL)METHYLTHIO] 4 PHENYL 6 (PIPERAZIN 1 YL)PYRIMIDINE 5 CARBONITRILE; 2 [(1H BENZO[D]IMIDAZOL 2 YL)METHYLTHIO] 4 PHENYL 6 (PYRIDIN 2 YLAMINO)PYRIMIDINE 5 CARBONITRILE; 2 [(1H BENZO[D]IMIDAZOL 2 YL)METHYLTHIO] 4 PHENYL 6 (PYRIDIN 4 YLAMINO)PYRIMIDINE 5 CARBONITRILE; 2 [(1H BENZO[D]IMIDAZOL 2 YL)METHYLTHIO] 4 PHENYL 6 [4 (2-PHENYLACETYL)PIPERAZIN 1 YL]PYRIMIDINE 5 CARBONITRILE; 2 [(1H BENZO[D]IMIDAZOL 2 YL)METHYLTHIO] 4 PHENYL 6 [4 (PHENYLSULPHONYL)PIPERAZIN 1 YL]PYRIMIDINE 5 CARBONITRILE; 7 [(1H BENZO[D]IMIDAZOL 2 YL)METHYLTHIO] 3,4 DIHYDRO 4 IMINO 5 PHENYLPYRIMIDO[4,5 D] PYRIMIDIN 2(1H)ONE; 7 [(1H BENZO[D]IMIDAZOL 2 YL)METHYLTHIO] 3,4 DIHYDRO 4 IMINO 5 PHENYLPYRIMIDO[4,5-D]PYRIMIDIN 2(1H)THIONE; ANTINEOPLASTIC AGENT; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LD 50; MOUSE; NONHUMAN; TUMOR GROWTH;

ANTINEOPLASTIC AGENTS; BENZIMIDAZOLES; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; LETHAL DOSE 50; PYRIMIDINES;

EID: 77950859296     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.02.011     Document Type: Article

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