Synthesis, biological activity and molecular modeling studies on 1H-benzimidazole derivatives as acetylcholinesterase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 17, 2013, Pages 4928-4937

  Alpan, Ayşe Selcen ^a   Parlar, Sülünay ^a   Carlino, Luca ^b   Tarikogullari, Ayse Hande ^a   Alptüzün, Vildan ^a   Güneş, Hasan Semih ^a  

^a EGE UNIVERSITY   (Turkey)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

1H Benzimidazole; Acetylcholinesterase inhibitor; Butyrylcholinesterase inhibitor; Molecular modeling; Synthesis

Indexed keywords

2 [4 (1H BENZO[D]IMIDAZOL 2 YL)PHENOXY] N,N DIETHYLETHANAMINE; 2 [4 (1H BENZO[D]IMIDAZOL 2 YL)PHENOXY] N,N DIMETHYLETHANAMINE; 2 [4 [2 (PIPERIDIN 1 YL)ETHOXY]PHENYL] 1H BENZO[D]IMIDAZOLE; 2 [4 [2 (PYRROLIDIN 1 YL)ETHOXY]PHENYL] 1H BENZO[D]IMIDAZOLE; 2 [4 [5 (6)CHLORO 1H BENZO[D]IMIDAZOL 2 YL]PHENOXY] N,N DIETHYLETHANAMINE; 2 [4 [5 (6)CHLORO 1H BENZO[D]IMIDAZOL 2 YL]PHENOXY] N,N DIMETHYLETHANAMINE; 4 [2 [4 (1H BENZO[D]IMIDAZOL 2 YL)PHENOXY]ETHYL]MORPHOLINE; 4 [2 [4 [5 (6)CHLORO 1H BENZO[D]IMIDAZOL 2 YL]PHENOXY]ETHYL]MORPHOLINE; 4 [2 [4 [5 (6)METHYL 1H BENZO[D]IMIDAZOL 2 YL]PHENOXY]ETHYL]MORPHOLINE; 5 (6)CHLORO 2 [4 [2 (PIPERIDIN 1 YL)ETHOXY]PHENYL] 1H BENZO[D]IMIDAZOLE; 5 (6)CHLORO 2 [4 [2 (PYRROLIDIN 1 YL)ETHOXY]PHENYL] 1H BENZO[D]IMIDAZOLE; 5 (6)METHYL 2 [4 [2 (PIPERIDIN 1 YL)ETHOXY]PHENYL] 1H BENZO[D]IMIDAZOLE; 5 (6)METHYL 2 [4 [2 (PYRROLIDIN 1 YL)ETHOXY]PHENYL] 1H BENZO[D]IMIDAZOLE; ACETYLCHOLINESTERASE; BENZIMIDAZOLE DERIVATIVE; CHOLINESTERASE; DONEPEZIL; N [2 [4 (1H BENZIMIDAZOLE 2 YL)PHENOXY]ETHYL]AMINE DERIVATIVE; N [2 [4 (1H BENZO[D]IMIDAZOL 2 YL)PHENOXY]ETHYL] N ISOPROPYLPROPAN 2 AMINE; N [2 [4 [5 (6)CHLORO 1H BENZO[D]IMIDAZOL 2 YL]PHENOXY]ETHYL] N ISOPROPYLPROPAN 2 AMINE; N,N DIETHYL 2 [4 [5 (6)METHYL 1H BENZO[D]IMIDAZOL 2 YL]PHENOXY]ETHANAMINE; N,N DIMETHYL 2 [4 [5 (6)METHYL 1H BENZO[D]IMIDAZOL 2 YL]PHENOXY]ETHANAMINE; TACRINE; UNCLASSIFIED DRUG;

ARTICLE; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR MODEL;

1H-BENZIMIDAZOLE; 5,5′-DITHIOBIS(2-NITROBENZOIC ACID); ACETYLCHOLINESTERASE; ACETYLCHOLINESTERASE INHIBITOR; ACETYLCHOLINESTERASE INHIBITORS; ACETYLTHIOCHOLINE IODIDE; ACHE; ACHEI; AD; ALZHEIMER'S DISEASE; ATC; AΒ; BUCHE; BUTYRYLCHOLINESTERASE; BUTYRYLCHOLINESTERASE INHIBITOR; CAS; CATALYTIC ACTIVE SITE; DTNB; EEACHE; ELECTROPHORUS ELECTRICUS ACHE; HACHE; HUMAN ACHE; MD; MOLECULAR DYNAMICS; MOLECULAR MODELING; PAS; PERIPHERAL ANIONIC SITE; RMSD; ROOT MEAN SQUARE DEVIATION; SYNTHESIS; TCACHE; TORPEDO CALIFORNICA ACHE; Β-AMYLOID;

ACETYLCHOLINESTERASE; ANIMALS; BENZIMIDAZOLES; BINDING SITES; BUTYRYLCHOLINESTERASE; CATALYTIC DOMAIN; CHOLINESTERASE INHIBITORS; HUMANS; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; TORPEDO;

EID: 84881371708     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.06.065     Document Type: Article

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