SCOPUS 정보 검색 플랫폼

Volumn 21, Issue 24, 2013, Pages 7612-7623

Design and synthesis of novel benzimidazole derivatives as phosphodiesterase 10A inhibitors with reduced CYP1A2 inhibition

(9) Hamaguchi, Wataru a Masuda, Naoyuki a Isomura, Mai a Miyamoto, Satoshi a Kikuchi, Shigetoshi a Amano, Yasushi a Honbou, Kazuya a Mihara, Takuma a Watanabe, Toshihiro a

a ASTELLAS PHARMA INC (Japan)

Author keywords

Benzimidazole; CYP1A2; PDE10A inhibitor; Schizophrenia

Indexed keywords

1 PHENYL 1H INDAZOLE 6 OL; 1 PHENYL 1H INDOL 6 OL; 2 [[(1 PHENYL 1H BENZIMIDAZOLE 6 YL)OXY]METHYL]QUINOLINE; 2 [[(1 PHENYL 1H INDAZOL 6 YL)OXY]METHYL]QUINOLINE HYDROCHLORIDE; 2 [[(1 PHENYL 2 PROPYL 1H BENZIMIDAZOLE 6 YL)OXY]METHYL]QUINOLINE DIHYDROCHLORIDE; 2 [[(2 CYCLOPROPYL 1 PHENYL 1H BENZIMIDAZOLE 6 YL)OXY]METHYL]QUINOLINE DIHYDROCHLORIDE; 2 [[(2 ETHYL 1 PHENYL 1H BENZIMIDAZOLE 6 YL)OXY]METHYL]QUINOLINE DIHYDROCHLORIDE; 2 [[(2 ISOBUTYL 1 PHENYL 1H BENZIMIDAZOLE 6 YL)OXY]METHYL]QUINOLINE DIHYDROCHLORIDE; 2 [[(2 ISOPROPYL 1 PHENYL 1H BENZIMIDAZOLE 6 YL)OXY]METHYL]QUINOLINE DIHYDROCHLORIDE; 2 [[(2 METHYL 1 PHENYL 1H BENZIMIDAZOLE 6 YL)OXY]METHYL]QUINOLINE DIHYDROCHLORIDE; 2 [[(3 PHENYL 1,2 BENZOXAZOL 5 YL)OXY]METHY]QUINOLINE HYDROCHLORIDE; 2 [[(5 FLUORO 1 PHENYL 1H BENZIMIDAZOLE 6 YL)OXY]METHYL]QUINOLINE DIHYDROCHLORIDE; 2 [[[1 PHENYL 2 (TRIFLUOROMETHYL) 1H BENZIMIDAZOLE 6 YL]OXY]METHYL]QUINOLINE DIHYROCHLORIDE; 2 [[[2 (METHOXYMETHYL) 1 PHENYL 1H BENZIMIDAZOLE 6 YL]OXY]METHYL]QUINOLINE DIHYDROCHLORIDE; 2 NITRO N PHENYL 5 (QUINOLIN 2 YLMETHOXY)ANILINE; 4 FLUORO 2 NITRO N PHENYL 5 (QUINOLIN 2 YLMETHOXY)ANILINE; 6 (BENZYLOXY) 1 HENYL 1H INDOLE; 6 METHOXY 1 PHENYL 1H INDAZOLE; 6 METHOXY 3 NITRO N PHENYLPYRIDIN 2 AMINE; BENZIMIDAZOLE; CARBOXYLIC ACID; CHLORIDE; CYCLIC AMP; CYTOCHROME P450 1A2; N PHENYL 4 (QUINOLIN 2 YLMETHOXY)BENZENE 1,2 DIAMINE; N,N DIMETHYL 1 PHENYL 6 (QUINOLIN 2 YLMETHOXY) 1H BENZIMIDAZOL 2 AMINE DIHYDROCHLORIDE; PHOSGENE; PHOSPHODIESTERASE; PHOSPHODIESTERASE 10A INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; CYCLIZATION; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; IN VITRO STUDY;

BENZIMIDAZOLE; CYP1A2; PDE10A INHIBITOR; SCHIZOPHRENIA;

BENZIMIDAZOLES; CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 CYP1A2; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84888438975 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2013.10.035 Document Type: Article

Times cited : (30)

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- Smith, D.A.¹ Allerton, C.² Kalgutkar, A.³ Van De Waterbeemd, H.⁴ Walker, D.K.⁵

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.