Dicationic biphenyl benzimidazole derivatives as antiprotozoal agents

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 20, 2004, Pages 5405-5413

  Ismail, Mohamed A ^a   Brun, Reto ^b   Wenzler, Tanja ^b   Tanious, Farial A ^a   Wilson, W David ^a   Boykin, David W ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

Author keywords

1,3 Phenylene; Antiprotozoal agents; Benzimidazoles; Diamidines; Suzuki coupling

Indexed keywords

2 (3' AMIDINO 4 HYDROXYBIPHENYL 3 YL) 1H BENZIMIDAZOL 5 AMIDINE ACETATE; 2 (4' AMIDINO 2' METHYLBIPHENYL 3 YL) 1H BENZIMIDAZOL 5 AMIDINE ACETATE; 2 (4' AMIDINO 4 HYDROXY 5 METHOXYBIPHENYL 3 YL) 1H BENZIMIDAZOL 5 AMIDINE ACETATE; 2 (4' AMIDINO 4 HYDROXYBIPHENYL 3 YL) 1H BENZIMIDAZOL 5 AMIDINE ACETATE; 2 [3 (5 AMIDINOPYRIDIN 2 YL)PHENYL] 1H BENZIMIDAZOL 5 AMIDINE ACETATE; 2 [5 (5 AMIDINOPYRIDIN 2 YL) 2 METHOXYPHENYL] 1H BENZIMIDAZOL 5 AMIDINE ACETATE; ANTIPROTOZOAL AGENT; BENZIMIDAZOLE DERIVATIVE; DIAMIDINE DERIVATIVE; DNA; HYDROXYL GROUP; PALLADIUM; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG SYNTHESIS; HYDROGENATION; IC 50; IN VIVO STUDY; NONHUMAN; PLASMODIUM FALCIPARUM; TRYPANOSOMA RHODESIENSE;

ANIMALS; ANTIPROTOZOAL AGENTS; BENZIMIDAZOLES; CATIONS, DIVALENT; MICE; PLASMODIUM FALCIPARUM; TRYPANOSOMA BRUCEI RHODESIENSE;

LATEOLABRAX JAPONICUS; PLASMODIUM FALCIPARUM; TRYPANOSOMA; TRYPANOSOMA BRUCEI; TRYPANOSOMA BRUCEI RHODESIENSE;

EID: 4544241506     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.07.056     Document Type: Article

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