Pyrido[1,2-a]benzimidazole-Based Agents Active Against Tuberculosis (TB), Multidrug-Resistant (MDR) TB and Extensively Drug-Resistant (XDR) TB

ChemMedChem

Volumn 6, Issue 2, 2011, Pages 334-342

  Pieroni, Marco ^a   Tipparaju, Suresh K ^a   Lun, Shichun ^b   Song, Yang ^a   Sturm, A Willem ^c   Bishai, William R ^b   Kozikowski, Alan P ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF KWAZULU NATAL   (South Africa)

Author keywords

Benzimidazole derivatives; Drug design; Drug discovery; Drug resistance; Tuberculosis

Indexed keywords

2 (2 CHLOROBENZYL) 3 METHYL 1 OXO 1H,5H PYRIDO[1,2 A]BENZIMIDAZOLE 4 CARBONITRILE; 2 (2,4 DIFLUOROBENZYL) 3 METHYL 1 OXO 1H,5H PYRIDO[1,2 A]BENZIMIDAZOLE 4 CARBONITRILE; 2 (3 CHLOROBENZYL) 3 METHYL 1 OXO 1H,5H PYRIDO[1,2 A]BENZIMIDAZOLE 4 CARBONITRILE; 2 (3,4 DICHLOROBENZYL) 3 METHYL 1 OXO 1H,5H PYRIDO[1,2 A]BENZIMIDAZOLE 4 CARBONITRILE; 2 (4 CHLOROBENZYL) 3 METHYL 1 OXO 1H,5H PYRIDO[1,2 A]BENZIMIDAZOLE 4 CARBONITRILE; 2 (4 FLUOROBENZYL) 3 METHYL 1 OXO 1H,5H PYRIDO[1,2 A]BENZIMIDAZOLE 4 CARBONITRILE; 3 METHYL 1 OXO 2 (2,3,4 TRIFLUOROBENZYL) 1H,5H PYRIDO[1,2 A]BENZIMIDAZOLE 4 CARBONITRILE; 3 METHYL 1 OXO 2 [(PYRIDIN 2 YL)METHYL] 1H,5H PYRIDO[1,2 A]BENZIMIDAZOLE 4 CARBONITRILE; 3 METHYL 1 OXO 2 [(PYRIDIN 3 YL)METHYL] 1H,5H PYRIDO[1,2 A]BENZIMIDAZOLE 4 CARBONITRILE; 3 METHYL 1 OXO 2 [(PYRIDIN 4 YL)METHYL] 1H,5H PYRIDO[1,2 A]BENZIMIDAZOLE 4 CARBONITRILE; 3 METHYL 1 OXO 2 [3 (TRIFLUOROMETHOXY)BENZYL] 1H,5H PYRIDO[1,2 A]BENZIMIDAZOLE 4 CARBONITRILE; 3 METHYL 1 OXO 2 [3 (TRIFLUOROMETHYL)BENZYL] 1H,5H PYRIDO[1,2 A]BENZIMIDAZOLE 4 CARBONITRILE; 3 METHYL 1 OXO 2 [4 (THIOMETHYL)BENZYL] 1H,5H PYRIDO[1,2 A]BENZIMIDAZOLE 4 CARBONITRILE; 3 METHYL 2 (3 METHOXYBENZYL) 1 OXO 1H,5H PYRIDO[1,2 A]BENZIMIDAZOLE 4 CARBONITRILE; 3 METHYL 2 (3 METHYLBENZYL) 1 OXO 1H,5H PYRIDO[1,2 A]BENZIMIDAZOLE 4 CARBONITRILE; 3 METHYL 2 (4 METHOXYBENZYL) 1 OXO 1H,5H PYRIDO[1,2 A]BENZIMIDAZOLE 4 CARBONITRILE; DRUG ANALOG; ETHYL 2 (2,3,4 TRIFLUOROBENZYL) 3 OXOBUTANOATE; ETHYL 2 (2,4 DIFLUOROBENZYL) 3 OXOBUTANOATE; ETHYL 2 (3 METHYLBENZYL) 3 OXOBUTANOATE; ETHYL 2 (3,4 DICHLOROBENZYL) 3 OXOBUTANOATE; ETHYL 2 (4 FLUOROBENZYL) 3 OXOBUTANOATE; ETHYL 2 (PYRIDIN 2 YL METHYL) 3 OXOBUTANOATE; ETHYL 2 [(4 CHLOROPHENYL)ETHYL] 3 OXOBUTANOATE; ETHYL 2 [3 (TRIFLUOROMETHOXY)BENZYL] 3 OXOBUTANOATE; ETHYL 2 [3 (TRIFLUOROMETHYL)BENZYL] 3 OXOBUTANOATE; ETHYL 2 [4 (METHYLTHIO)BENZYL] 3 OXOBUTANOATE; ETHYL 2[4 (PYRIDIN 2 YL) BENZYL] 3 OXOBUTANOATE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; EXTENSIVELY DRUG RESISTANT TUBERCULOSIS; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MULTIDRUG RESISTANT TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; TUBERCULOSIS; VERO CELL;

ANTITUBERCULAR AGENTS; BENZIMIDAZOLES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG RESISTANCE, MICROBIAL; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS;

EID: 79251569911     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000490     Document Type: Article

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