SCOPUS 정보 검색 플랫폼

Volumn 21, Issue 21, 2013, Pages 6788-6795

Selective inhibition of heme oxygenase-2 activity by analogs of 1-(4-chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzimidazole (clemizole): Exploration of the effects of substituents at the N-1 position

(4) Vlahakis, Jason Z a Vukomanovic, Dragic a Nakatsu, Kanji a Szarek, Walter A a

a QUEEN S UNIVERSITY (Canada)

Author keywords

Carbon monoxide; Clemizole analogs; Heme; Heme oxygenase; Selective inhibitors

Indexed keywords

1 (2 CHLOROBENZYL) 2 (PYRROLIDIN 1 YLMETHYL) 1H BENZIMIDAZOLE; 1 (2,4 DICHLOROBENZYL) 2 (PYRROLIDIN 1 YLMETHYL) 1H BENZIMIDAZOLE; 1 (2,5 DICHLOROBENZYL) 2 (PYRROLIDIN 1 YLMETHYL) 1H BENZIMIDAZOLE; 1 (3 BROMOBENZYL) 2 (PYRROLIDIN 1 YLMETHYL) 1H BENZIMIDAZOLE; 1 (3 METHYLBENZYL) 2 (PYRROLIDIN 1 YLMETHYL) 1H BENZIMIDAZOLE; 1 (3 NITROBENZYL) 2 (PYRROLIDIN 1 YLMETHYL) 1H BENZIMIDAZOLE; 1 (4 BENZYLOBENZYL) 2 (PYRROLIDIN 1 YLMETHYL) 1H BENZIMIDAZOLE; 1 (4 BROMOBENZYL) 2 (PYRROLIDIN 1 YLMETHYL) 1H BENZIMIDAZOLE; 1 (4 CYANOBENZYL) 2 (PYRROLIDIN 1 YLMETHYL) 1H BENZIMIDAZOLE; 1 (4 FLUOROBENZYL) 2 (PYRROLIDIN 1 YLMETHYL) 1H BENZIMIDAZOLE; 1 (4 METHYLBENZYL) 2 (PYRROLIDIN 1 YLMETHYL) 1H BENZIMIDAZOLE; 1 (4 TRIFLUOROMETHYLBENZYL) 2 (PYRROLIDIN 1 YLMETHYL) 1H BENZIMIDAZOLE; CLEMIZOLE; HEME OXYGENASE 2; HEME OXYGENASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

CARBON MONOXIDE; CLEMIZOLE ANALOGS; HEME; HEME OXYGENASE; SELECTIVE INHIBITORS;

ANIMALS; BENZIMIDAZOLES; BRAIN; ENZYME INHIBITORS; HEME OXYGENASE (DECYCLIZING); HEME OXYGENASE-1; PROTEIN BINDING; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84885184350 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2013.07.050 Document Type: Article

Times cited : (19)

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