Synthesis and bioevaluation of novel 3,4,5-trimethoxybenzylbenzimidazole derivatives that inhibit Helicobacter pylori-induced pathogenesis in human gastric epithelial cells

European Journal of Medicinal Chemistry

Volumn 48, Issue , 2012, Pages 244-254

  Chang, Chih Shiang ^a   Liu, Ju Fang ^a   Lin, Hwai Jeng ^b   Lin, Chia Der ^c,d   Tang, Chih Hsin ^c   Lu, Dah Yuu ^a   Sing, Yu Ting ^c   Chen, Li Yu ^c   Kao, Min Chuan ^c   Kuo, Sheng Chu ^a   Lai, Chih Ho ^c,e,f  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^e UNIVERSITY OF TEXAS AT DALLAS   (United States)

^f NATIONAL TSING HUA UNIVERSITY   (Taiwan)

Author keywords

2 Fluorophenyl 5 methyl 1 (3,4,5 trimethoxybenzyl)benzimidazole; Antibiotic resistant; Benzimidazole; Helicobacter pylori; Human gastric epithelial cells; Interleukin 8

Indexed keywords

2 (2 CHLOROPHENYL) 5 METHYL 1 (3,4,5 TRIMETHOXYBENZYL)BENZIMIDAZOLE; 2 (2 FLUOROPHENYL) 5 METHYL 1 (3,4,5 TRIMETHOXYBENZYL)BENZIMIDAZOLE; 2 (2 METHOXYPHENYL) 5 METHYL 1 (3,4,5 TRIMETHOXYBENZYL)BENZIMIDAZOLE; 2 (2 METHYLPHENYL) 5 METHYL 1 (3,4,5 TRIMETHOXYBENZYL)BENZIMIDAZOLE; 2 (3 FLUOROPHENYL) 5 METHYL 1 (3,4,5 TRIMETHOXYBENZYL)BENZIMIDAZOLE; 2 (3 METHOXYPHENYL) 5 METHYL 1 (3,4,5 TRIMETHOXYBENZYL)BENZIMIDAZOLE; 2 (3 METHYLPHENYL) 5 METHYL 1 (3,4,5 TRIMETHOXYBENZYL)BENZIMIDAZOLE; 2 (3,4 DICHLOROPHENYL) 5 METHYL 1 (3,4,5 TRIMETHOXYBENZYL)BENZIMIDAZOLE; 2 (4 FLUOROPHENYL) 5 METHYL 1 (3,4,5 TRIMETHOXYBENZYL)BENZIMIDAZOLE; 2 (4 METHOXYPHENYL) 5 METHYL 1 (3,4,5 TRIMETHOXYBENZYL)BENZIMIDAZOLE; 2 (4 METHOXYPHENYL) 6 METHYL 1 (3,4,5 TRIMETHOXYBENZYL)BENZIMIDAZOLE; 2 FLUOROPHENYL 5 METHYL 1 (3,4,5 TRIMETHOXYBENZYL)BENZIMIDAZOLE; 3,4,5 TRIMETHOXYBENZYLBENZIMIDAZOLE DERIVATIVE; 5 CHLORO 1 (3,4,5 TRIMETHOXYPHENYL)BENZIMIDAZOLE; 5 CHLORO 2 (4 METHOXYPHENYL) 1 (3,4,5 TRIMETHOXYBENZYL)BENZIMIDAZOLE; 5 FLUORO 2 PHENYL (3,4,5 TRIMETHOXYBENZYL)BENZIMIDAZOLE; 5 METHYL 2 (NAPHTHALEN 1 YL) 1 (3,4,5 TRIMETHOXYBENZYL)BENZIMIDAZOLE; 5 METHYL 2 (NAPHTHALEN 2 YL) 1 (3,4,5 TRIMETHOXYBENZYL)BENZIMIDAZOLE; 5 METHYL 2 PHENYL 1 (3,4,5 TRIMETHOXYBENZYL)BENZIMIDAZOLE; 5 METHYL 2 STYRYL 1 (3,4,5 TRIMETHOXYBENZYL)BENZIMIDAZOLE; 5,6 DIMETHYL 2 PHENYL 1 (3,4,5 TRIMETHOXYBENZYL)BENZIMIDAZOLE; 6 CHLORO 2 PHENYL 1 (3,4,5 TRIMETHOXYBENZYL)BENZIMIDAZOLE; 6 METHOXY 2 PHENYL 1 (3,4,5 TRIMETHOXYBENZYL)BENZIMIDAZOLE; 6 METHYL 2 PHENYL 1 (3,4,5 TRIMETHOXYBENZYL)BENZIMIDAZOLE; AMOXICILLIN; ANTIBIOTIC AGENT; BENZIMIDAZOLE DERIVATIVE; CLARITHROMYCIN; METRONIDAZOLE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GROWTH; BACTERIUM ADHERENCE; CONTROLLED STUDY; DRUG SYNTHESIS; HELICOBACTER INFECTION; HELICOBACTER PYLORI; NONHUMAN; STOMACH EPITHELIUM;

EID: 84856022426     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.12.021     Document Type: Article

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