Design, synthesis and pharmacological evaluation of omeprazole-like agents with anti-inflammatory activity

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 7, 2013, Pages 1661-1670

  El Nezhawy, Ahmed O H ^a,b   Biuomy, Ayman R ^a,b   Hassan, Fatma S ^a   Ismaiel, Ayman K ^a   Omar, Hany A ^a,c  

^a TAIF UNIVERSITY   (Saudi Arabia)

^b NATIONAL RESEARCH CENTRE   (Egypt)

^c Beni Suef University   (Egypt)

Author keywords

2 Methyl 1H benzimidazole; Anti inflammatory activity; Anti ulcerogenic activity; Cyclic sulfate; Omeprazole

Indexed keywords

1 (5 HYDROXYBENZYL 2,3 O ISOPROPYLIDENE ALPHA DEXTRO MANNOFURANOSE) 5 [(PYRIDIN 2 YLMETHYL)AMINO] 2 METHYL 1H BENZIMIDAZOLE; 1 (5 HYDROXYBENZYL 2,3 O ISOPROPYLIDENE ALPHA DEXTRO MANNOFURANOSE) 5 [[(3,4 DIMETHOXYPYRIDIN 2 YL)METHYL]AMINO] 2 METHYL 1H BENZIMIDAZOLE; 1 (5 HYDROXYBENZYL 2,3 O ISOPROPYLIDENE ALPHA DEXTRO MANNOFURANOSE) 5 [[(4 METHOXY 3 METHYLPYRIDIN 2 YL)METHYL]AMINO] 2 METHYL 1H BENZIMIDAZOLE; 1 (5 HYDROXYBENZYL 2,3 O ISOPROPYLIDENE ALPHA DEXTRO MANNOFURANOSE) 5 [[(4 METHOXY 3,5 DIMETHYLPYRIDIN 2 YL)METHYL]AMINO] 2 METHYL 1H BENZIMIDAZOLE; 2 METHYL N (PYRIDIN 2 YLMETHYL) 1H BENZIMIDAZOL 5 AMINE; 2 METHYL N [(3,4 DIMETHOXYPYRIDIN 2 YL)METHYL] 1H BENZIMIDAZOL 5 AMINE; 2 METHYL N [(4 METHOXY 3 METHYLPYRIDIN 2 YL)METHYL] 1H BENZIMIDAZOL 5 AMINE; 2 METHYL N [(4 METHOXY 3,5 DIMETHYLPYRIDIN 2 YL)METHYL] 1H BENZIMIDAZOL 5 AMINE; ALCOHOL; BENZIMIDAZOLE DERIVATIVE; BENZYL 2,3 O ISOPROPYLIDENE 5,6 O SULFURYL ALPHA DEXTRO MANNOFURANOSIDE; DICLOFENAC; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; OMEPRAZOLE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIULCER ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG DESIGN; DRUG DOSE COMPARISON; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; MOUSE; NONHUMAN; PAW EDEMA; PYLORUS LIGATION; RAT; STOMACH ULCER;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTI-ULCER AGENTS; BENZIMIDAZOLES; CARRAGEENAN; DRUG DESIGN; EDEMA; MICE; OMEPRAZOLE; RATS; RATS, SPRAGUE-DAWLEY; STOMACH ULCER;

RATTUS;

EID: 84875210886     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.01.070     Document Type: Article

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