Novel trisubstituted benzimidazoles, targeting Mtb FtsZ, as a new class of antitubercular agents

Journal of Medicinal Chemistry

Volumn 54, Issue 1, 2011, Pages 374-381

  Kumar, Kunal ^a   Awasthi, Divya ^a   Lee, Seung Yub ^a   Zanardi, Ilaria ^a   Ruzsicska, Bela ^a   Knudson, Susan ^b   Tonge, Peter J ^a   Slayden, Richard A ^b   Ojima, Iwao ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b Department of Ecosystem Science and Sustainability   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 BENZYLOXYCARBONYLAMINO 2 CYCLOHEXYL 6 (PYRROLIDIN 1 YL) 1H BENZO(D)IMIDAZOLE; 5 BUT 3 ENOXYCARBONYLAMINO 2 CYCLOHEXYL 6 N,N DIETHYLAMINO 1H BENZO(D)IMIDAZOLE; 5 BUTOXYCARBONYLAMINO 2 CYCLOHEXYL 6 (PYRROLIDIN 1 YL) 1H BENZO(D)IMIDAZOLE; 7 ACETYLAMINO 5 ETHOXYCARBONYLAMINO 2 PHENYL 1H BENZO(D)IMIDAZOLE; BENZIMIDAZOLE DERIVATIVE; GUANOSINE TRIPHOSPHATASE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG RESISTANCE; DRUG SYNTHESIS; ENZYME ACTIVITY; IC 50; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; SCANNING ELECTRON MICROSCOPY; STRUCTURE ACTIVITY RELATION; VERO CELL;

ANIMALS; ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; BENZIMIDAZOLES; CERCOPITHECUS AETHIOPS; CYTOSKELETAL PROTEINS; GTP PHOSPHOHYDROLASES; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; STRUCTURE-ACTIVITY RELATIONSHIP; VERO CELLS;

EID: 78651094980     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1012006     Document Type: Article

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