New benzimidazole derivatives as antiplasmodial agents and plasmepsin inhibitors: Synthesis and analysis of structure-activity relationships

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 2, 2012, Pages 1282-1286

  Saify, Zafar Saied ^a   Azim, M Kamran ^a   Ahmad, Waseem ^b   Nisa, Mehrun ^a   Goldberg, Daniel E ^c   Hussain, Shaheen A ^a   Akhtar, Shamim ^a   Akram, Arfa ^a   Arayne, Arshad ^a   Oksman, Anna ^c   Khan, Ishtiaq A ^b  

^a UNIVERSITY OF KARACHI   (Pakistan)

^b FEDERAL URDU UNIVERSITY OF ARTS   (Pakistan)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antimalarial; Aspartic protease; Cathepsin D; FlexX docking; Flow cytometry

Indexed keywords

1 (4 PHENYLPHENYL) 2 [2 (PYRIDINYL 2 YL) 1,3 BENZDIAZOL 1 YL]ETHANONE; BENZIMIDAZOLE DERIVATIVE; CATHEPSIN; PLASMEPSIN II; PLASMEPSIN INHIBITOR; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; MOLECULAR DOCKING; NONHUMAN; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION;

ANTIMALARIALS; ASPARTIC ACID ENDOPEPTIDASES; BENZIMIDAZOLES; CATHEPSIN D; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

PLASMODIUM FALCIPARUM;

EID: 84855651652     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.10.018     Document Type: Article

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