Benzimidazol-2-ylidene gold(I) complexes are thioredoxin reductase inhibitors with multiple antitumor properties

Journal of Medicinal Chemistry

Volumn 53, Issue 24, 2010, Pages 8608-8618

  Rubbiani, Riccardo ^a   Kitanovic, Igor ^b   Alborzinia, Hamed ^b   Can, Suzan ^b   Kitanovic, Ana ^b   Onambele, Liliane A ^c   Stefanopoulou, Maria ^d   Geldmacher, Yvonne ^d   Sheldrick, William S ^d   Wolber, Gerhard ^e   Prokop, Aram ^c   Wölfl, Stefan ^b   Ott, Ingo ^a  

^a TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^d RUHR UNIVERSITY BOCHUM   (Germany)

^e FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BENZIMIDAZOLE DERIVATIVE; CARBENE; CHLORO (1,3 DIBENZYLBENZIMIDAZOL 2 YLIDENE)GOLD; CHLORO (1,3 DIETHYLBENZIMIDAZOL 2 YLIDENE)GOLD; CHLORO (1,3 DIMETHYLBENZIMIDAZOL 2 YLIDENE)GOLD; CHLORO [1,3 BIS(DIPHENYLMETHYL)BENZIMIDAZOL 2 YLIDENE]GOLD; DNA FRAGMENT; GLUTATHIONE; GLUTATHIONE REDUCTASE; GOLD COMPLEX; HETEROCYCLIC COMPOUND; LACTATE DEHYDROGENASE; LIGAND; REACTIVE OXYGEN METABOLITE; THIOREDOXIN REDUCTASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL METABOLISM; CELL RESPIRATION; CELL SURFACE; CELL VIABILITY; CONTROLLED STUDY; DRUG SELECTIVITY; ENZYME INHIBITION; GLYCOLYSIS; HUMAN; HUMAN CELL; MITOCHONDRIAL RESPIRATION; MOLECULAR STABILITY;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZIMIDAZOLES; CELL LINE, TUMOR; CELL PROLIFERATION; CELL RESPIRATION; COORDINATION COMPLEXES; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; GLUTATHIONE; GLUTATHIONE REDUCTASE; GLYCOLYSIS; GOLD; HUMANS; MICE; MITOCHONDRIA, LIVER; MODELS, MOLECULAR; OXYGEN CONSUMPTION; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP; THIOREDOXIN-DISULFIDE REDUCTASE;

EID: 78650373807     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100801e     Document Type: Article

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