Synthesis, pharmacological screening, quantum chemical and in vitro permeability studies of N-Mannich bases of benzimidazoles through bovine cornea

European Journal of Medicinal Chemistry

Volumn 44, Issue 5, 2009, Pages 2307-2312

  Jesudason, E Philip ^a,d   Sridhar, S K ^b,d   Malar, E J Padma ^c   Shanmugapandiyan, P ^d   Inayathullah, Mohammed ^a   Arul, V ^a   Selvaraj, D ^a   Jayakumar, R ^a  

^a CENTRAL LEATHER RESEARCH INSTITUTE   (India)

^b HIGHER COLLEGE OF TECHNOLOGY   (Oman)

^c UNIVERSITY OF MADRAS   (India)

^d VELS INSTITUTE OF SCIENCE   (India)

Author keywords

Analgesic; Anti inflammatory; Benzimidazole; Corneal permeability; Mannich base; Quantum chemical calculations

Indexed keywords

1 [(DIETHYLAMINO) METHYL] 2 STYRYLBENZIMIDAZOLE; 1 [(DIETHYLAMINO)METHYL]BENZIMIDAZOLE; 1 [(DIMETHYLAMINO)METHY]BENZIMIDAZOLE; 1 [(DIPHENYLAMINO) METHYL] 2 METHYLBENZIMIDAZOLE; 1 [(MORPHOLINO)METHYL] 2 STYRYLBENZIMIDAZOLE; 1 [(PIPERIDIN 1 YL) METHYL] 2 STYRYLBENZIMIDAZOLE; 2 METHYLBENZIMIDAZOLE; 2 STYRYLBENZIMIDAZOLE; BENZIMIDAZOLE; BENZIMIDAZOLE DERIVATIVE; DICLOFENAC; MANNICH BASE; PARACETAMOL; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CALCULATION; CONTROLLED STUDY; CORNEA; CORNEA PERMEABILITY; CORRELATION ANALYSIS; COW; DRUG MECHANISM; DRUG PENETRATION; DRUG SCREENING; DRUG SYNTHESIS; ENERGY; HYDROGEN BOND; INFRARED SPECTROSCOPY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; QUANTUM CHEMISTRY;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; BENZIMIDAZOLES; CATTLE; CELL MEMBRANE PERMEABILITY; CORNEA; DRUG EVALUATION, PRECLINICAL; HYDROGEN BONDING; MANNICH BASES; MODELS, MOLECULAR;

EID: 62749112851     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.03.043     Document Type: Article

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