Benzimidazole clubbed with triazolo-thiadiazoles and triazolo-thiadiazines: New anticancer agents

European Journal of Medicinal Chemistry

Volumn 62, Issue , 2013, Pages 785-798

  Husain, Asif ^a   Rashid, Mohd ^a   Shaharyar, M ^a   Siddiqui, Anees A ^a   Mishra, Ravinesh ^a  

^a HAMDARD UNIVERSITY   (India)

Author keywords

Anticancer; Benzimidazole; Thiadiazine; Thiadiazole; Triazole

Indexed keywords

1 (1 H BENZO[D]IMIDAZOL 2 YL) 3 [6 (CHLOROMETHYL) [1,2,4]TRIAZOLO[3,4 B][1,3,4] THIADIAZOL 3 YL]PROPAN 1 ONE; 1 (1H BENZO[D]IMIDAZOL 2 YL) 3 (6 (3 AMINOPROPYL) [1,2,4]TRIAZOLO[3,4 B][1,3,4] THIADIAZOL 3 YL)PROPAN 1 ONE; 1 (1H BENZO[D]IMIDAZOL 2 YL) 3 (6 AMINO 7H [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZIN 3 YL)PROPAN 1 ONE; 1 (1H BENZO[D]IMIDAZOL 2 YL) 3 (6 BENZHYDRYL [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOL 3 YL)PROPAN 1 ONE; 1 (1H BENZO[D]IMIDAZOL 2 YL) 3 (6 ETHOXY [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOL 3 YL) PROPAN 1 ONE; 1 (1H BENZO[D]IMIDAZOL 2 YL) 3 (6 HYDROXY 7H [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZIN 3 YL)PROPAN 1 ONE; 1 (1H BENZO[D]IMIDAZOL 2 YL) 3 (6 MERCAPTO [1,2,4]TRIAZOLO[3,4 B][1,3,4] TRIAZOLO[3,4 B][1,3,4] THIADIAZOL 3 YL)PROPAN 1 ONE; 1 (1H BENZO[D]IMIDAZOL 2 YL) 3 (6 METHYL [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOL 3 YL) PROPAN 1 ONE; 1 (1H BENZO[D]IMIDAZOL 2 YL) 3 (6 VINYL [1,2,4]TRIAZOLO[3,4B][1,3,4]THIADIAZOL 3 YL) PROPAN 1 ONE; 1 (1H BENZO[D]IMIDAZOL 2 YL) 3 [6 (2 AMINOPHENYL) [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIA ZOL 3 YL]PROPAN 1 ONE; 1 (1H BENZO[D]IMIDAZOL 2 YL) 3 [6 (2 CHLOROBENZYL) [1,2,4]TRIAZOLO[3,4 B][1,3,4] THIADIAZOL 3 YL]PROPAN 1 ONE; 1 (1H BENZO[D]IMIDAZOL 2 YL) 3 [6 (2 CHLOROETHYL) [1,2,4]TRIAZOLO[3,4 B][1,3,4] THIADIAZOLE 3 YL]PROPAN 1 ONE; 1 (1H BENZO[D]IMIDAZOL 2 YL) 3 [6 (2 HYDROXYPHENYL) [1,2,4]TRIAZOLO[3,4 B][1,3,4] THIADIAZOL 3 YL]PROPAN 1 ONE; 1 (1H BENZO[D]IMIDAZOL 2 YL) 3 [6 (2,4 DICHLOROPHENYL) [1,2,4]TRIAZOLO[3,4 B][1,3,4] THIADIAZOL 3 YL]PROPAN 1 ONE; 1 (1H BENZO[D]IMIDAZOL 2 YL) 3 [6 (3 CHLOROPROPYL) [1,2,4]TRIAZOLO[3,4 B][1,3,4] THIADIAZOL 3 YL]PROPAN 1 ONE; 1 (1H BENZO[D]IMIDAZOL 2 YL) 3 [6 (4 CHLOROPHENY LTHIO) [1,2,4]TRIAZOLO[3,4 B] [1,3,4]THIADIAZOL 3 YL]PROPAN 1 ONE; 1 (1H BENZO[D]IMIDAZOL 2 YL) 3 [6 (4 HYDROXYPHENYL) [1,2,4]TRIAZOLO[3,4 B][1,3,4] THIADIAZOL 3 YL]PROPAN 1 ONE; 1 (1H BENZO[D]IMIDAZOL 2 YL) 3 [6 (4 METHOXYPHENYL) [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOL 3 YL]PROPAN 1 ONE; 1 (1H BENZO[D]IMIDAZOL 2 YL) 3 [6 (5 AMINO 2 HYDROXYPHENYL) [1,2,4]TRIAZOLO[3,4 B] [1,3,4]THIADIAZOL 3 YL]PROPAN 1 ONE; 1 (1H BENZO[D]IMIDAZOL 2 YL) 3 [6 (MERCAPTOMETHYL) [1,2,4]TRIAZOLO[3,4 B][1,3,4] THIADIAZOL 3 YL]PROPAN 1 ONE; 1 (1H BENZO[D]IMIDAZOL 2 YL) 3 [6 (PHENOXYMETHYL) [1,2,4]TRIAZOLO[3,4 B][1,3,4] THIADIAZOL 3 YL] PROPAN 1 ONE; 1 (1H BENZO[D]IMIDAZOL 2 YL) 3 [6 (PROP 1 ENYL) [1,2,4]TRIAZOLO[3,4 B][1,3,4] THIADIAZOL 3 YL]PROPAN 1 ONE; 1 (1H BENZO[D]IMIDAZOL 2 YL)3 [6 (2 MERCAPTOPHENYL) [1,2,4]TRIAZOLO[3,4 B][1,3,4] THIADIAZOL 3 YL]PROPAN 1 ONE; 2 (3 (3 (1H BENZO[D]IMIDAZOL 2 YL) 3 OXOPROPYL) [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOL 6 YL)ACETONITRILE; 2 [3 [3 (1H BENZO[D]IMIDAZOL 2 YL) 3 OXOPROPYL] [1,2,4]TRIAZOLO[3,4 B][1,3,4]THIADIAZOL 6 YL]PHENYL ACETATE; ANTINEOPLASTIC AGENT; BENZIMIDAZOLE DERIVATIVE; THIADIAZINE DERIVATIVE; THIADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONCENTRATION (PARAMETERS); DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; IN VITRO STUDY; LEUKEMIA CELL LINE;

ANTINEOPLASTIC AGENTS; BENZIMIDAZOLES; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZINES; THIADIAZOLES; TRIAZOLES;

EID: 84876013863     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.07.011     Document Type: Article

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