Potent and selective inhibition of human cytomegalovirus replication by 1263W94, a benzimidazole L-riboside with a unique mode of action

Antimicrobial Agents and Chemotherapy

Volumn 46, Issue 8, 2002, Pages 2365-2372

  Biron, Karen K ^a   Harvey, Robert J ^a   Chamberlain, Stanley C ^a   Good, Steven S ^a   Smith III, Albert A ^a   Davis, Michelle G ^a   Talarico, Christine L ^a   Miller, Wayne H ^a   Ferris, Robert ^a   Dornsife, Ronna E ^a   Stanat, Sylvia C ^a   Drach, John C ^a   Townsend, Leroy B ^a   Koszalka, George W ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1H BETA DEXTRO RIBOFURANOSIDE 2 BROMO 5,6 DICHLOROBENZIMIDAZOLE; BENZIMIDAVIR; BENZIMIDAZOLE DERIVATIVE; DNA POLYMERASE; FOSCARNET; GANCICLOVIR; GENE PRODUCT; UNCLASSIFIED DRUG; VIRUS DNA; ANTIVIRUS AGENT; BIOLOGICAL MARKER; DNA DIRECTED DNA POLYMERASE; PROTEIN KINASE; RIBONUCLEOSIDE;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; COSMID; CYTOTOXICITY; DNA HYBRIDIZATION; DNA SYNTHESIS; DNA SYNTHESIS INHIBITION; DOSE RESPONSE; DRUG STRUCTURE; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; MINIMUM INHIBITORY CONCENTRATION; OPEN READING FRAME; PHOSPHORYLATION; PRIORITY JOURNAL; SEQUENCE ANALYSIS; STRUCTURE ACTIVITY RELATION; VIRUS GENE; VIRUS INHIBITION; VIRUS ISOLATION; VIRUS MUTATION; VIRUS REPLICATION; ANTIBIOTIC RESISTANCE; BIOSYNTHESIS; CELL CULTURE; CELL SURVIVAL; CYTOMEGALOVIRUS; DNA SEQUENCE; DRUG ANTAGONISM; DRUG EFFECT; DRUG RESISTANCE; ENZYMOLOGY; ERYTHROID PRECURSOR CELL; FIBROBLAST; GENETICS; METABOLISM;

ANTIVIRAL AGENTS; BENZIMIDAZOLES; BIOLOGICAL MARKERS; CELL SURVIVAL; CELLS, CULTURED; CYTOMEGALOVIRUS; DNA, VIRAL; DNA-DIRECTED DNA POLYMERASE; DRUG RESISTANCE; DRUG RESISTANCE, MICROBIAL; ERYTHROID PROGENITOR CELLS; FIBROBLASTS; HUMAN; PHOSPHORYLATION; PROTEIN KINASES; RIBONUCLEOSIDES; SEQUENCE ANALYSIS, DNA; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION; HUMANS;

EID: 0035991720     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.46.8.2365-2372.2002     Document Type: Article

References (30)

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