Studies towards the identification of putative bioactive conformation of potent vasodilator arylidene N-acylhydrazone derivatives

European Journal of Medicinal Chemistry

Volumn 44, Issue 10, 2009, Pages 4004-4009

  Kümmerle, Arthur E ^a   Raimundo, Juliana M ^a   Leal, Carla M ^a   da Silva, Givanildo S ^b   Balliano, Tatiane L ^c   Pereira, Mariano A ^b   de Simone, Carlos A ^b   Sudo, Roberto T ^a   Zapata Sudo, Gisele ^a   Fraga, Carlos A M ^a   Barreiro, Eliezer J ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b FEDERAL UNIVERSITY OF ALAGOAS   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Bioactive conformation; N Acylhydrazone; Vasodilation

Indexed keywords

(2 FURANYLIDENE) 3,4 METHYLENEDIOXYBENZOYLHYDRAZINE; (2 PYRROLIDENE) 3,4 METHYLENEDIOXYBENZOYLHYDRAZINE; (BENZYLIDENE) 3,4 METHYLENEDIOXYBENZOYLHYDRAZINE; 3,4 METHYLENEDIOXYBENZOYL 2 THIENYLHYDRAZONE; HYDRAZONE DERIVATIVE; LASSBIO 1003; LASSBIO 1004; LASSBIO 1028; LASSBIO 123; LASSBIO 129; LASSBIO 1456; LASSBIO 294; LASSBIO 785; N ACYLHYDRAZONE DERIVATIVE; N METHYL (2 FURANYLIDENE) 3,4 METHYLENEDIOXYBENZOYLHYDRAZINE; N METHYL (2 PYRROLIDENE) 3,4 METHYLENEDIOXYBENZOYLHYDRAZINE; N METHYL (BENZYLIDENE) 3,4 METHYLENEDIOXYBENZOYLHYDRAZINE; N METHYL N ACYLHYDRAZONE DERIVATIVE; UNCLASSIFIED DRUG; VASODILATOR AGENT;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG CONFORMATION; DRUG DESIGN; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; MALE; NONHUMAN; RAT; REACTION ANALYSIS; STRUCTURE ANALYSIS; VASODILATATION;

ANIMALS; AORTA, THORACIC; CRYSTALLOGRAPHY, X-RAY; HYDRAZONES; MALE; MODELS, MOLECULAR; RATS; RATS, WISTAR; THIOPHENES; VASODILATOR AGENTS;

EID: 67651165022     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.04.044     Document Type: Article

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