Fragment-based design of symmetrical bis-benzimidazoles as selective inhibitors of the trimethoprim-resistant, type II R67 dihydrofolate reductase

Journal of Medicinal Chemistry

Volumn 55, Issue 7, 2012, Pages 3182-3192

  Bastien, Dominic ^a   Ebert, Maximilian C C J C ^a   Forge, Delphine ^b   Toulouse, Jacynthe ^a   Kadnikova, Natalia ^a   Perron, Florent ^b   Mayence, Annie ^c   Huang, Tien L ^c   Vanden Eynde, Jean Jacques ^b   Pelletier, Joelle N ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITY OF MONS   (Belgium)

^c XAVIER UNIVERSITY OF LOUISIANA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BENZIMIDAZOLE DERIVATIVE; DIHYDROFOLATE REDUCTASE INHIBITOR; ENZYME VARIANT; TRIMETHOPRIM;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG TARGETING; ENZYME INHIBITION; FRAGMENTATION REACTION; HUMAN; IN VITRO STUDY; MOLECULAR MODEL; MOUSE; NONHUMAN;

EID: 84859805882     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201645r     Document Type: Article

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