Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents

European Journal of Medicinal Chemistry

Volumn 62, Issue , 2013, Pages 111-121

  Wang, Xue Quan ^a   Liu, Lan Xiang ^a   Li, Yan ^b   Sun, Cheng Jun ^a   Chen, Wen ^a   Li, Liang ^a   Zhang, Hong Bin ^a   Yang, Xiao Dong ^a  

^a YUNNAN UNIVERSITY   (China)

^b KUNMING INSTITUTE OF BOTANY   (China)

Author keywords

2 Benzylbenzofuran; Cytotoxic activities; Hybrid compound; Imidazole; Structure activity relationships

Indexed keywords

1 [BENZOFURAN 2 YL(PHENYL)METHYL)] 2 METHYL 3 (2 OXO 2 PHENYLETHYL) 1H IMIDAZOL 3 IUM BROMIDE; 1 [BENZOFURAN 2 YL(PHENYL)METHYL] 1H BENZO IMIDAZOLE; 1 [BENZOFURAN 2 YL(PHENYL)METHYL] 1H IMIDAZOLE; 1 [BENZOFURAN 2 YL(PHENYL)METHYL] 2 ETHYL 1H IMIDAZOLE; 1 [BENZOFURAN 2 YL(PHENYL)METHYL] 2 ETHYL 3 [2 (4 FLUOROPHENYL)2 OXOETHYL] 1H IMIDAZOL 3 IUM BROMIDE; 1 [BENZOFURAN 2 YL(PHENYL)METHYL] 2 METHYL 1H IMIDAZOLE; 1 [BENZOFURAN 2 YL(PHENYL)METHYL] 2 METHYL 3 [2 (NAPHTHALEN 2 YL) 2 OXOETHYL] 1H IMIDAZOL 3 IUM BROMIDE; 1 [BENZOFURAN 2 YL(PHENYL)METHYL] 3 (2 OXO 2 PHENYLETHYL) 1H IMIDAZOL 3 IUM BROMIDE; 1 [BENZOFURAN 2 YL(PHENYL)METHYL] 3 (4 NITROBENZYL) 1H IMIDAZOL 3 IUM BROMIDE; 1 [BENZOFURAN 2 YL(PHENYL)METHYL] 3 [2 (4 BROMOPHENYL) 2 OXOETHYL] 1H IMIDAZOL 3 IUM BROMIDE; 1 [BENZOFURAN 2 YL(PHENYL)METHYL] 3 [2 (4 BROMOPHENYL)2 OXOETHYL] 2 METHYL 1H IMIDAZOL 3 IUM BROMIDE; 1 [BENZOFURAN 2 YL(PHENYL)METHYL] 3 [2 (4 FLUOROPHENYL) 2 OXOETHYL] 1H IMIDAZOL 3 IUM BROMIDE; 1 [BENZOFURAN 2 YL(PHENYL)METHYL] 3 [2 (4 FLUOROPHENYL)2 OXOETHYL] 2 METHYL 1H IMIDAZOL 3 IUM BROMIDE; 1 [BENZOFURAN 2 YL(PHENYL)METHYL] 3 [2 (4 HYDROXYPHENYL)2 OXOETHYL] 2 METHYL 1H IMIDAZOL 3 IUM BROMIDE; 1 [BENZOFURAN 2 YL(PHENYL)METHYL] 3 [2 (4 METHOXYPHENYL) 2 OXOETHYL] 1H IMIDAZOL 3 IUM BROMIDE; 1 [BENZOFURAN 2 YL(PHENYL)METHYL] 3 [2 (4 METHOXYPHENYL)2 OXOETHYL] 2 METHYL 1H IMIDAZOL 3 IUM BROMIDE; 1 [BENZOFURAN 2 YL(PHENYL)METHYL] 3 [2 (NAPHTHALEN 2 YL) 2 OXOETHYL] 1H IMIDAZOL 3 IUM BROMIDE; 1 [BENZOFURAN 2 YL(PHENYL)METHYL] 3 ALLYL 1H IMIDAZOL 3 IUM BROMIDE; 1 [BENZOFURAN 2 YL(PHENYL)METHYL] 3 ALLYL 2 ETHYL 1H IMIDAZOL 3 IUM BROMIDE; 1 [BENZOFURAN 2 YL(PHENYL)METHYL] 3 BENZYL 1H IMIDAZOL 3 IUM BROMIDE; 1 [BENZOFURAN 2 YL(PHENYL)METHYL] 3 BENZYL 2 ETHYL 1H IMIDAZOL 3 IUM BROMIDE; 1 [BENZOFURAN 2 YL(PHENYL)METHYL] 3 BENZYL 2 METHYL 1H IMIDAZOL 3 IUM BROMIDE; 1 [BENZOFURAN 2 YL(PHENYL)METHYL] 3 BUTYL 1H IMIDAZOL 3 IUM IODIDE; 1 [BENZOFURAN 2 YL(PHENYL)METHYL] 3 BUTYL 2 ETHYL 1H IMIDAZOL 3 IUM IODIDE; 1 [BENZOFURAN 2 YL(PHENYL)METHYL] 3 BUTYL 2 METHYL 1H IMIDAZOLE 3 IUM IODIDE; 1 [BENZOFURAN 2 YL(PHENYL)METHYL]3 ALLYL 2 METHYL 1H IMIDAZOLE 3 IUM BROMIDE; ANTINEOPLASTIC AGENT; BENZIMIDAZOLE DERIVATIVE; CISPLATIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CELL STRAIN MCF 7; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL CARCINOMA; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANTINEOPLASTIC AGENTS; BENZIMIDAZOLES; BENZOFURANS; CELL LINE, TUMOR; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HL-60 CELLS; HUMANS; IMIDAZOLES; MCF-7 CELLS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84872687427     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.12.040     Document Type: Article

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