Inhibition of the helicase activity of the HCV NS3 protein by symmetrical dimeric bis-benzimidazoles

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 18, 2011, Pages 5331-5335

  Tunitskaya, Vera L ^a   Mukovnya, Anna V ^a,b   Ivanov, Alexander A ^a,c   Gromyko, Alexander V ^a   Ivanov, Alexander V ^a   Streltsov, Sergey A ^a   Zhuze, Alexei L ^a   Kochetkov, Sergey N ^a,b  

^a ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

^b MOSCOW STATE UNIVERSITY   (Russian Federation)

^c N N BLOKHIN RUSSIAN CANCER RESEARCH CENTER   (Russian Federation)

Author keywords

Dimeric bis benzimidazoles; Helicase; Hepatitis C virus; Inhibitor; NS3 protein

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; DIMERIC BIS BENZIMIDAZOLE DERIVATIVE; HELICASE; NONSTRUCTURAL PROTEIN 3; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME INHIBITION; HEPATITIS C VIRUS; LIGAND BINDING;

BENZIMIDAZOLES; DIMERIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 80051929472     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.07.018     Document Type: Article

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