Recognition of HIV-TAR RNA using neomycin-benzimidazole conjugates

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 20, 2013, Pages 5689-5693

  Ranjan, Nihar ^a   Kumar, Sunil ^a,d   Watkins, Derrick ^b   Wang, Deyun ^c   Appella, Daniel H ^c   Arya, Dev P ^a,b  

^a CLEMSON UNIVERSITY   (United States)

^b NUBAD LLC   (United States)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^d YALE UNIVERSITY   (United States)

Author keywords

Aminoglycosides; Benzimidazole; Neomycin; TAR; tat TAR inhibition

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; DNA B; NEOMYCIN;

ARTICLE; CHEMICAL STRUCTURE; DENATURATION; DRUG CONJUGATION; HUMAN IMMUNODEFICIENCY VIRUS; IC 50; RNA BINDING; ULTRAVIOLET RADIATION;

AMINOGLYCOSIDES; BENZIMIDAZOLE; CD; CIRCULAR DICHROISM; FID; FLUORESCENT INTERCALATORS DISPLACEMENT; MALDI-TOF; MATRIX ASSISTED LASER DESORPTION AND IONIZATION-TIME OF FLIGHT; NA; ND; NEOMYCIN; NMR; NOT AVAILABLE; NOT DETERMINED; NUCLEAR MAGNETIC RESONANCE; TAR; TAT-TAR INHIBITION; TRANS ACTIVATING REGION; ULTRA VIOLET; UV;

BENZIMIDAZOLES; BISBENZIMIDAZOLE; CIRCULAR DICHROISM; HIV LONG TERMINAL REPEAT; HIV-1; HUMANS; LIGANDS; NEOMYCIN; RNA, VIRAL; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS;

EID: 84884289813     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.08.014     Document Type: Article

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