Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 15, 2013, Pages 4374-4380

  Bibian, Mathieu ^a   Rahaim, Ronald J ^a   Choi, Jun Yong ^a   Noguchi, Yoshihiko ^a   Schürer, Stephan ^b   Chen, Weimin ^a   Nakanishi, Shima ^a   Licht, Konstantin ^a   Rosenberg, Laura H ^a   Li, Lin ^a   Feng, Yangbo ^a   Cameron, Michael D ^a   Duckett, Derek R ^a   Cleveland, John L ^a   Roush, William R ^a  

^a Scripps Florida ^*  (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Antiproliferative agent; Casein kinase 1 inhibitor; Potent growth inhibitor of A375 melanoma cell line; Purine scaffold kinase inhibitor; Selective CK1 inhibitor

Indexed keywords

ANTINEOPLASTIC AGENT; CASEIN KINASE IDELTA; CASEIN KINASE IDELTA INHIBITOR; CASEIN KINASE IEPSILON; CASEIN KINASE IEPSILON INHIBITOR; PHOSPHOTRANSFERASE INHIBITOR; SR 1277; SR 2890; SR 3029; SR 653234; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BRAIN CANCER; CANCER CELL CULTURE; DRUG CLEARANCE; DRUG HALF LIFE; DRUG PENETRATION; DRUG SCREENING; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; BINDING SITES; CASEIN KINASE IDELTA; CASEIN KINASE IEPSILON; CATALYTIC DOMAIN; CELL LINE, TUMOR; CELL SURVIVAL; HALF-LIFE; HUMANS; MICE; MICROSOMES, LIVER; MOLECULAR DOCKING SIMULATION; NEOPLASMS; PURINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPLANTATION, HETEROLOGOUS;

ANIMALIA;

EID: 84879693358     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.05.075     Document Type: Article

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