Toward novel HIV-1 integrase binding inhibitors: Molecular modeling, synthesis, and biological studies

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 19, 2007, Pages 5370-5373

  Mugnaini, Claudia ^a   Rajamaki, Suvi ^a   Tintori, Cristina ^a   Corelli, Federico ^a   Massa, Silvio ^a   Witvrouw, Myriam ^c   Debyser, Zeger ^c   Veljkovic, Veljko ^b   Botta, Maurizio ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY OF BELGRADE   (Serbia)

^c UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

HIV 1; Integrase inhibitors

Indexed keywords

1 [5 (4 FLUOROBENZYL) 2 FURYL] 3 (1,2,4 TRIAZOL 3 YL) 1,3 PROPANEDIONE; HUMAN IMMUNODEFICIENCY VIRUS 1 INTEGRASE BINDING INHIBITOR; INTEGRASE INHIBITOR; N (4 FLUOROBENZYL) 8 HYDROXY 5 (TETRAHYDRO 2H 1,2 THIAZIN 2 YL) 1,6 NAPHTHYRIDINE 7 CARBOXAMIDE S,S DIOXIDE; PYRANODIPYRIMIDINE; STYRYLQUINOLINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; MOLECULAR MODEL; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN STRUCTURE; PROTEIN SYNTHESIS;

COMPUTER SIMULATION; DATABASES, FACTUAL; DRUG EVALUATION, PRECLINICAL; HIV INTEGRASE INHIBITORS; HIV-1; INDICATORS AND REAGENTS; LIGANDS; MODELS, MOLECULAR;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 34548592004     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.08.005     Document Type: Article

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