Synthesis, vasorelaxant activity and antihypertensive effect of benzo[d]imidazole derivatives

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 11, 2010, Pages 3985-3991

  Navarrete Vázquez, Gabriel ^a   Hidalgo Figueroa, Sergio ^a   Torres Piedra, Mariana ^a   Vergara Galicia, Jorge ^a   Rivera Leyva, Julio Cesar ^a,d   Estrada Soto, Samuel ^a   León Rivera, Ismael ^b   Aguilar Guardarrama, Berenice ^b   Rios Gómez, Yolanda ^b   Villalobos Molina, Rafael ^c   Ibarra Barajas, Maximiliano ^c  

^a UNIVERSIDAD AUTÓNOMA DEL ESTADO DE MORELOS   (Mexico)

^b CENTRO DE INVESTIGACIONES QUÍMICAS   (Mexico)

^c UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^d UNIVERSITY OF GUANAJUATO   (Mexico)

Author keywords

Antihypertensive activity; Benzimidazoles; SHR; Vasorelaxant effect

Indexed keywords

2 (2 ETHOXYPHENYL) 5 (TRIFLUOROMETHYL) 1H BENZO[D]IMIDAZOLE; 2 (2 ETHOXYPHENYL) 5 NITRO 1H BENZO[D]IMIDAZOLE; 2 (2 ISOPROPOXYPHENYL) 5 NITRO 1H BENZO[D]IMIDAZOLE; 2 (2 METHOXYPHENYL) 5 (TRIFLUOROMETHYL) 1H BENZO[D]IMIDAZOLE; 2 (2 NITROPHENYL) 5 (TRIFLUOROMETHYL) 1H BENZO[D]IMIDAZOLE; 2 (3,4 DIMETHOXYPHENYL) 5 NITRO 1H BENZO[D]IMIDAZOLE; 2 (4 PROPOXYPHENYL) 5 (TRIFLUOROMETHYL) 1H BENZO[D]IMIDAZOLE; 2 (BENZO[D][1,3]DIOXOL 5 YL) 5 (TRIFLUOROMETHYL) 1H BENZO[D]IMIDAZOLE; 2 METHOXY 4 (5 NITRO 1H BENZO[D]IMIDAZOL 2 YL)PHENOL; 2 METHOXY 4 [5 (TRIFLUOROMETHYL) 1H BENZO[D]IMIDAZOL 2 YL]PHENOL; 2 PHENYL 5 (TRIFLUOROMETHYL) 1H BENZO[D]IMIDAZOLE; 4 [5 (TRIFLUOROMETHYL) 1H BENZO[D]IMIDAZOL 2 YL]PHENOL; 5 NITRO 2 (3,4,5 TRIMETHOXYPHENYL) 1H BENZO[D]IMIDAZOLE; 5 NITRO 2 PHENYL 1H BENZO[D]IMIDAZOLE; BENZIMIDAZOLE DERIVATIVE; CARBACHOL; N,N DIMETHYL 4 [5 (TRIFLUOROMETHYL) 1H BENZO[D]IMIDAZOL 2 YL]ANILINE; NITRENDIPINE; NITRO DERIVATIVE; NITROGEN DIOXIDE; PIMOBENDAN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; DRUG SYNTHESIS; EX VIVO STUDY; MALE; NONHUMAN; RAT; SUBSTITUTION REACTION; VASCULAR ENDOTHELIUM; VASCULAR RING; VASODILATATION;

ANIMALS; ANTIHYPERTENSIVE AGENTS; AORTA; DOSE-RESPONSE RELATIONSHIP, DRUG; IMIDAZOLES; PYRIDAZINES; RATS; RATS, INBRED SHR; STRUCTURE-ACTIVITY RELATIONSHIP; VASODILATOR AGENTS;

RATTUS;

EID: 77953135310     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.04.027     Document Type: Article

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