Synthesis and pharmacological evaluation of novel 5-substituted-1-(phenylsulfonyl)-2-methylbenzimidazole derivatives as anti-inflammatory and analgesic agents

European Journal of Medicinal Chemistry

Volumn 45, Issue 6, 2010, Pages 2245-2249

  Gaba, Monika ^a,b   Singh, Dhandeep ^b   Singh, Sarbjot ^b,c   Sharma, Vikas ^b   Gaba, Punam ^a  

^a Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy   (India)

^b PUNJABI UNIVERSITY   (India)

^c Biology Research   (India)

Author keywords

2 Methylbenzimidazole; Analgesic activity; Anti inflammatory activity; Carrageenan induced paw edema model

Indexed keywords

2 METHYL 1 (PHENYLSULFONYL) BENZIMIDAZOL 5 AMINE; 2 METHYL 1 (PHENYLSULFONYL) N PROPYL 1H BENZIMIDAZOL 5 AMINE; 2 METHYL N (2 CHLOROBENZYL) 1 (PHENYLSULFONYL) 1H BENZIMIDAZOL 5 AMINE; 2 METHYL N (4 CHLOROBENZYL) 1 (PHENYLSULFONYL) 1H BENZIMIDAZOL 5 AMINE; 2 METHYL N 2 (NITROPHENYL) 1 (PHENYLSULFONYL) 1H BENZIMIDAZOL 5 AMINE; 2 METHYL N 4 (NITROBENZYL) 1 (PHENYLSULFONYL) 1H BENZIMIDAZOL 5 AMINE; 2 METHYL N 4 (NITROPHENYL) 1 (PHENYLSULFONYL) 1H BENZIMIDAZOL 5 AMINE; ACETIC ACID; ACETYLSALICYLIC ACID; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; BENZIMIDAZOLE DERIVATIVE; CARRAGEENAN; INDOMETACIN; N 2 DIMETHYL 1 (PHENYLSULFONYL) 1H BENZIMIDAZOL 5 AMINE; N 4 (AMINOBENZYL) 2 METHYL 1 (PHENYLSULFONYL) 1H BENZIMIDAZOL 5 AMINE; N [2 METHY 1 (PHENYLSULFONYL) 1H BENZIMIDAZOL 5 YL] BENZENE 1,2 DIAMINE; N [2 METHY 1 (PHENYLSULFONYL) 1H BENZIMIDAZOL 5 YL] BENZENE 1,4 DIAMINE; N BUTYL 2 METHYL 1 (PHENYLSULFONYL) 1H BENZIMIDAZOL 5 AMINE; N ETHYL 2 METHYL 1 (PHENYLSULFONYL) 1H BENZIMIDAZOL 5 AMINE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; INFLAMMATION; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; PAIN; PAW EDEMA; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STOMACH ULCER; ULCEROGENESIS; WRITHING TEST;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; BENZIMIDAZOLES; CARRAGEENAN; EDEMA; MALE; MICE; RATS; ULCER;

EID: 77950864109     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.01.067     Document Type: Article

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