Synthesis of novel 1,2,5-trisubstituted benzimidazoles as potential antitumor agents

European Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2011, Pages 4062-4070

  Abonia, Rodrigo ^a   Cortés, Edwar ^a   Insuasty, Braulio ^a   Quiroga, Jairo ^a   Nogueras, Manuel ^b   Cobo, Justo ^b  

^a UNIVERSIDAD DEL VALLE   (Colombia)

^b UNIVERSITY OF JAÉN   (Spain)

Author keywords

Antitumor agents; Nucleophilic aromatic substitution; Pyrazole derivatives; Solvent free reaction conditions; Trisubstituted benzimidazoles

Indexed keywords

3 ACETAMIDO 4 (1 ACETYL 3 TERT BUTYL 1H PYRAZOL 5 YLAMINO)BENZOATE; ANTINEOPLASTIC AGENT; BENZIMIDAZOLE DERIVATIVE; METHYL 1 (5 TERT BUTYL 1H PYRAZOL 3 YL) 2 (2 HYDROXYPHENYL) 1H BENZO[D]IMIDAZOLE 5 CARBOXYYLATE; METHYL 1 (5 TERT BUTYL 1H PYRAZOL 3 YL) 2 (2 OXO 1,2 DIHYDROQUINOLIN 3 YL) 1H BENZO[D]IMIDAZOLE 5 CARBOXYLATE; METHYL 1 (5 TERT BUTYL 1H PYRAZOL 3 YL) 2 (3 HYDROXY 4 METHOXYPHENYL) 1H BENZO[D]IMIDAZOLE 5 CARBOXYLATE; METHYL 1 (5 TERT BUTYL 1H PYRAZOL 3 YL) 2 (3,4 DIMETHOXYPHENYL) 1H BENZO[D]IMIDAZOLE 5 CABOXYLATE; METHYL 1 (5 TERT BUTYL 1H PYRAZOL 3 YL) 2 (3,4,5 TRIMETHOXYPHENYL) 1H BENZO[D]IMIDAZOLE 5 CARBOXYLATE; METHYL 1 (5 TERT BUTYL 1H PYRAZOL 3 YL) 2 (4 BROMOPHENYL) 1H BENZO[D]IMIDAZOLE 5 CARBOXYLATE; METHYL 1 (5 TERT BUTYL 1H PYRAZOL 3 YL) 2 (4 CHLOROPHENYL) 1H BENZO[D]IMIDAZOLE 5 CARBOXYLATE; METHYL 1 (5 TERT BUTYL 1H PYRAZOL 3 YL) 2 (4 FLUOROPHENYL) 1H BENZO[D]IMIDAZOLE 5 CARBOXYLATE; METHYL 1 (5 TERT BUTYL 1H PYRAZOL 3 YL) 2 (4 METHOXYPHENYL) 1H BENZO[D]IMIDAZOLE 5 CARBOXYLATE; METHYL 1 (5 TERT BUTYL 1H PYRAZOL 3 YL) 2 (4 METHYLPHENYL) 1H BENZO[D]IMIDAZOLE 5 CARBOXYLATE; METHYL 1 (5 TERT BUTYL 1H PYRAZOL 3 YL) 2 (4 TRIFLUOROMETHYL)PHENYL) 1H BENZO[D]IMIDAZOLE 5 CARBOXYLATE; METHYL 1 (5 TERT BUTYL 1H PYRAZOL 3 YL) 2 PHENYL 1H BENZO[D]IMIDAZOLE 5 CARBOXYLATE; METHYL 1 (5 TERT BUTYL 1H PYRAZOL 3 YL) 2 [4 (DIMETHYLAMINO)PHENYL] 1H BENZO[D]IMIDAZOLE 5 CARBOXYLATE; METHYL 2 (BENZO[D] [1,3]DIOXO 5 YL) 1 (5 TERT BUTYL 1H PYRAZOL 3 YL) 1H BENZO[D]IMIDAZOLE 5 CARBOXYLATE; METHYL 3 AMINO 4 [(3 TERT BUTYL 1H PYRAZOL 5 YL)AMINO]BENZOATE; METHYL 4 FLUORO 3 NITROBENZOATE; METHYL 4 [(3 TERT BUTYL 1H PYRAZOL 5 YL)AMINO] 3 NITROBENZOATE; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER INHIBITION; CYCLIZATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LEUKEMIA CELL; LUNG NON SMALL CELL CANCER; MELANOMA CELL; TAUTOMERIZATION; X RAY DIFFRACTION;

EID: 80052956378     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.06.006     Document Type: Article

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