Derivatives of benzimidazole pharmacophore: Synthesis, anticonvulsant, antidiabetic and DNA cleavage studies

European Journal of Medicinal Chemistry

Volumn 45, Issue 5, 2010, Pages 1753-1759

  Shingalapur, Ramya V ^a   Hosamani, Kallappa M ^a   Keri, Rangappa S ^a   Hugar, Mallinath H ^a  

^a KARNATAK UNIVERSITY   (India)

Author keywords

1,3,4 Oxadiazoles; 2 Mercapto benzimidazole; 4 Thiazolidinones; Anticonvulsant; Antidiabetic; DNA cleavage

Indexed keywords

1,3,4 OXADIAZOLE DERIVATIVE; 2 [5 (2 CHLORO 4 NITRO PHENYL)[1,3,4]OXADIAZOLE 2 YLMETHYLSULFANYL] 1H BENZIMIDAZOLE; 2 [5 (4 NITRO PHENYL)[1,3,4]OXADIAZOLE 2 YLMETHYLSULFANYL] 1H BENZIMIDAZOLE; 2 BENZIMIDAZOLETHIOL DERIVATIVE; 3 (1H BENZIMIDAZOL 2 YLSULFANYLMETHYL) 2 (2 HYDROXY 3 METHOXY PHENYL)THIAZOLIDIN 4 ONE; 3 (1H BENZIMIDAZOL 2 YLSULFANYLMETHYL) 2 (2 HYDROXY PHENYL)THIAZOLIDIN 4 ONE; 3 (1H BENZIMIDAZOL 2 YLSULFANYLMETHYL) 2 (3 HYDROXYNAPHTHALEN 2 YL) THIAZOLIDIN 4 ONE; 3 (1H BENZIMIDAZOL 2 YLSULFANYLMETHYL) 2 (4 HYDROXY PHENYL)THIAZOLIDIN 4 ONE; 3 [5 (1H BENZIMIDAZOL 2 YLSULFANYLMETHYL)[1,3,4]OXADIAZOLE 2 YL]NAPHTHALENE 2 OL; 4 [5 (1H BENZIMIDAZOL 2 YLSULFANYLMETHYL)[1,3,4]OXADIAZOLE 2 YL]PHENOL; 4 THIAZOLIDINONE DERIVATIVE; ANTICONVULSIVE AGENT; ANTIDIABETIC AGENT; BENZIMIDAZOLE DERIVATIVE; CARBAMAZEPINE; DNA; GLIBENCLAMIDE; PHENYTOIN; UNCLASSIFIED DRUG;

ANTICONVULSANT ACTIVITY; ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CONVULSION; DNA CLEAVAGE; DRUG ACTIVITY; DRUG EFFICACY; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; HYPERGLYCEMIA; IN VIVO STUDY; MALE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PHARMACOPHORE; RAT;

ANIMALS; ANTICONVULSANTS; BENZIMIDAZOLES; DIABETES MELLITUS, EXPERIMENTAL; DNA CLEAVAGE; DNA, BACTERIAL; DRUG EVALUATION, PRECLINICAL; FEMALE; HYPOGLYCEMIC AGENTS; MALE; MOLECULAR STRUCTURE; MOTOR ACTIVITY; RATS; RATS, WISTAR; ROTAROD PERFORMANCE TEST; SEIZURES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77949486916     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.01.007     Document Type: Article

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