Novel N1-substituted 1,3-dihydro-2H-benzimidazol-2-ones as potent non-nucleoside reverse transcriptase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 15, 2008, Pages 7429-7435

  Monforte, Anna Maria ^a   Rao, Angela ^a   Logoteta, Patrizia ^a   Ferro, Stefania ^a   De Luca, Laura ^a   Barreca, Maria Letizia ^b   Iraci, Nunzio ^a   Maga, Giovanni ^c   De Clercq, Erik ^d   Pannecouque, Christophe ^d   Chimirri, Alba ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF PERUGIA   (Italy)

^c CNR   (Italy)

^d REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Benzimidazolones; Microwave assisted synthesis; Molecular modeling; RT inhibitors

Indexed keywords

3 ACETYL 6 CHLORO 1 (2,6 DIFLUOROBENZYL) 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; 3 ACETYL 6 CHLORO 1 (3,5 DIFLUOROBENZYL) 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; 3 ACETYL 6 CHLORO 1 (3,5 DIMETHYLBENZYL) 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; 6 CHLORO 1 (2,6 DIFLUOROBENZYL 1,3 DIHYDRO 2H BENZIMIDAZOL 2 THIONE; 6 CHLORO 1 (2,6 DIFLUOROPHENYLSULFONYL) 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; 6 CHLORO 1 (3,5 DIFLUOROBENZYL 1,3 DIHYDRO 2H BENZIMIDAZOL 2 THIONE; 6 CHLORO 1 (3,5 DIFLUOROBENZYL) 1,3 DIHYDRO 2H BENZIMIDAZOLE 2 ONE; 6 CHLORO 1 (3,5 DIFLUOROPHENYLSULFONYL) 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; 6 CHLORO 1 (3,5 DIMETHYLBENZYL 1,3 DIHYDRO 2H BENZIMIDAZOL 2 THIONE; 6 CHLORO 5 FLUORO (2,6 DIFLUOROBENZYL) 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; 6 CHLORO 5 FLUORO (3,5 DIFLUOROBENZYL) 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; 6 CHLORO 5 FLUORO (3,5 DIMETHYLBENZYL) 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; 6 CHLORO 5 FLUORO 1 (3,5 DIMETHYLPHENYLSULFONYL) 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; 6 METHYL 1 (2,6 DIFLUOROBENZYL) 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; 6 METHYL 1 (2,6 DIFLUOROPHENYLSULFONYL) 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; 6 METHYL 1 (3,5 DIFLUOROBENZYL) 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; 6 METHYL 1 (3,5 DIFLUOROLPHENYLSULFONYL) 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; 6 METHYL 1 (3,5 DIMETHYLBENZYL) 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; 6 METHYL 1 (3,5 DIMETHYLPHENYLSULFONYL) 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; 6 TRIFLUOROMETHYL 1 (2,6 DIFLUOROBENZYL) 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; 6 TRIFLUOROMETHYL 1 (3,5 DIMETHYLBENZYL) 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BENZIMIDAZOLE DERIVATIVE; EFAVIRENZ; NEVIRAPINE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; STRUCTURE ACTIVITY RELATION; VIRUS REPLICATION; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ANTI-HIV AGENTS; BENZIMIDAZOLES; CELL LINE; HIV-1; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

EID: 48449096508     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.06.012     Document Type: Article

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