Synthesis and biological analysis of benzazol-2-yl piperazine sulfonamides as 11β-hydroxysteroid dehydrogenase 1 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 19, 2013, Pages 5397-5400

  Hofer, Sandra ^a   Kratschmar, Denise V ^b   Schernthanner, Brigitte ^a   Vuorinen, Anna ^a   Schuster, Daniela ^a   Odermatt, Alex ^b   Easmon, Johnny ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b UNIVERSITY OF BASEL   (Switzerland)

Author keywords

11 Hydroxysteroid dehydrogenase; 2 Benzazolylpiperazine; Metabolic diseases; Molecular modeling; Structure activity relationships (SAR)

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; SULFONAMIDE;

ARTICLE; CRYSTAL STRUCTURE; DRUG SYNTHESIS; MOLECULAR DOCKING; MOLECULAR MODEL; NUCLEOPHILICITY; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

11Β-HYDROXYSTEROID DEHYDROGENASE; 2-BENZAZOLYLPIPERAZINE; METABOLIC DISEASES; MOLECULAR MODELING; STRUCTURE-ACTIVITY RELATIONSHIPS (SAR);

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ANIMALS; AZOLES; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; PIPERAZINES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 84883489738     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.07.047     Document Type: Article

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