메뉴 건너뛰기




Volumn 8, Issue 12, 2016, Pages

Genome-editing technologies: Principles and applications

Author keywords

[No Author keywords available]

Indexed keywords

ENDONUCLEASE;

EID: 85006058313     PISSN: None     EISSN: 19430264     Source Type: Journal    
DOI: 10.1101/cshperspect.a023754     Document Type: Article
Times cited : (220)

References (256)
  • 2
    • 0041806648 scopus 로고    scopus 로고
    • Chimeric recombinases with designed DNA sequence recognition
    • Akopian A, He J, Boocock MR, Stark WM. 2003. Chimeric recombinases with designed DNA sequence recognition. Proc Natl Acad Sci 100: 8688-8691
    • (2003) Proc Natl Acad Sci , vol.100 , pp. 8688-8691
    • Akopian, A.1    He, J.2    Boocock, M.R.3    Stark, W.M.4
  • 3
    • 84908508061 scopus 로고    scopus 로고
    • Structural basis of PAM-dependent targetDNA recognition by the Cas9 endonuclease
    • Anders C, Niewoehner O, Duerst A, Jinek M. 2014. Structural basis of PAM-dependent targetDNA recognition by the Cas9 endonuclease. Nature 513: 569-573
    • (2014) Nature , vol.513 , pp. 569-573
    • Anders, C.1    Niewoehner, O.2    Duerst, A.3    Jinek, M.4
  • 6
    • 84941047606 scopus 로고    scopus 로고
    • Conditionally stabilized dCas9 activator for controlling gene expression in human cell reprogramming and differentiation
    • Balboa D, Weltner J, Eurola S, Trokovic R, Wartiovaara K, Otonkoski T. 2015. Conditionally stabilized dCas9 activator for controlling gene expression in human cell reprogramming and differentiation. Stem Cell Rep 5: 448-459
    • (2015) Stem Cell Rep , vol.5 , pp. 448-459
    • Balboa, D.1    Weltner, J.2    Eurola, S.3    Trokovic, R.4    Wartiovaara, K.5    Otonkoski, T.6
  • 7
    • 84921594086 scopus 로고    scopus 로고
    • Enabling plant synthetic biology through genome engineering
    • Baltes NJ, Voytas DF. 2015. Enabling plant synthetic biology through genome engineering. Trends Biotechnol 33: 120-131
    • (2015) Trends Biotechnol , vol.33 , pp. 120-131
    • Baltes, N.J.1    Voytas, D.F.2
  • 8
    • 0036168937 scopus 로고    scopus 로고
    • Engineering polydactyl zincfinger transcription factors
    • Beerli RR, Barbas CF III. 2002. Engineering polydactyl zincfinger transcription factors. Nat Biotechnol 20: 135-141
    • (2002) Nat Biotechnol , vol.20 , pp. 135-141
    • Beerli, R.R.1    Barbas, C.2
  • 9
    • 0032437591 scopus 로고    scopus 로고
    • Toward controlling gene expression at will: Specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks
    • Beerli RR, Segal DJ, Dreier B, Barbas CF III 1998. Toward controlling gene expression at will: Specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks. Proc Natl Acad Sci 95: 14628-14633
    • (1998) Proc Natl Acad Sci , vol.95 , pp. 14628-14633
    • Beerli, R.R.1    Segal, D.J.2    Dreier, B.3    Barbas, C.F.4
  • 10
    • 0034652141 scopus 로고    scopus 로고
    • Positive and negative regulation of endogenous genes by designed transcription factors
    • Beerli RR, Dreier B, Barbas CF III 2000a. Positive and negative regulation of endogenous genes by designed transcription factors. Proc Natl Acad Sci 97: 1495-1500
    • (2000) Proc Natl Acad Sci , vol.97 , pp. 1495-1500
    • Beerli, R.R.1    Dreier, B.2    Barbas, C.F.3
  • 11
    • 0034693062 scopus 로고    scopus 로고
    • Chemically regulated zinc finger transcription factors
    • Beerli RR, Schopfer U, Dreier B, Barbas CF III 2000b. Chemically regulated zinc finger transcription factors. J Biol Chem 275: 32617-32627
    • (2000) J Biol Chem , vol.275 , pp. 32617-32627
    • Beerli, R.R.1    Schopfer, U.2    Dreier, B.3    Barbas, C.F.4
  • 14
    • 0036021389 scopus 로고    scopus 로고
    • Targeted chromosomal cleavage and mutagenesis in Drosophila using zinc-finger nucleases
    • Bibikova M, Golic M, Golic KG, Carroll D. 2002. Targeted chromosomal cleavage and mutagenesis in Drosophila using zinc-finger nucleases. Genetics 161: 1169-1175
    • (2002) Genetics , vol.161 , pp. 1169-1175
    • Bibikova, M.1    Golic, M.2    Golic, K.G.3    Carroll, D.4
  • 15
    • 0037510038 scopus 로고    scopus 로고
    • Enhancing gene targeting with designed zinc finger nucleases
    • Bibikova M, Beumer K, Trautman JK, Carroll D. 2003. Enhancing gene targeting with designed zinc finger nucleases. Science 300: 764.
    • (2003) Science , vol.300 , pp. 764
    • Bibikova, M.1    Beumer, K.2    Trautman, J.K.3    Carroll, D.4
  • 21
    • 84866879789 scopus 로고    scopus 로고
    • Iterative capped assembly: Rapid and scalable synthesis of repeat-module DNA such as TAL effectors from individual monomers
    • Briggs AW, Rios X, Chari R, Yang L, Zhang F, Mali P, Church GM. 2012. Iterative capped assembly: rapid and scalable synthesis of repeat-module DNA such as TAL effectors from individual monomers. Nucleic Acids Res 40: e117.
    • (2012) Nucleic Acids Res , pp. 40
    • Briggs, A.W.1    Rios, X.2    Chari, R.3    Yang, L.4    Zhang, F.5    Mali, P.6    Church, G.M.7
  • 22
    • 0038027293 scopus 로고    scopus 로고
    • Site-specific selfish genes as tools for the control and genetic engineering of natural populations
    • Burt A. 2003. Site-specific selfish genes as tools for the control and genetic engineering of natural populations. Proc Biol Sci 270: 921-928
    • (2003) Proc Biol Sci , vol.270 , pp. 921-928
    • Burt, A.1
  • 23
    • 85044694762 scopus 로고    scopus 로고
    • Targeted genome editing by lentiviral protein transduction of zinc-finger and TALeffector nucleases
    • Cai Y, Bak RO, Mikkelsen JG. 2014. Targeted genome editing by lentiviral protein transduction of zinc-finger and TALeffector nucleases. eLife 3: e01911.
    • (2014) Elife , vol.3
    • Cai, Y.1    Bak, R.O.2    Mikkelsen, J.G.3
  • 28
    • 84894248678 scopus 로고    scopus 로고
    • Induced DNA demethylation by targeting Ten-Eleven Translocation 2 to the human ICAM-1 promoter
    • Chen H, Kazemier HG, de Groote ML, Ruiters MH, Xu GL, Rots MG. 2014. Induced DNA demethylation by targeting Ten-Eleven Translocation 2 to the human ICAM-1 promoter. Nucleic Acids Res 42: 1563-1574
    • (2014) Nucleic Acids Res , vol.42 , pp. 1563-1574
    • Chen, H.1    Kazemier, H.G.2    de Groote, M.L.3    Ruiters, M.H.4    Xu, G.L.5    Rots, M.G.6
  • 30
    • 84874624936 scopus 로고    scopus 로고
    • Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease
    • Cho SW, Kim S, Kim JM, Kim JS. 2013. Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease. Nat Biotechnol 31: 230-232
    • (2013) Nat Biotechnol , vol.31 , pp. 230-232
    • Cho, S.W.1    Kim, S.2    Kim, J.M.3    Kim, J.S.4
  • 31
    • 0027994717 scopus 로고
    • Toward a code for the interactions of zinc fingers with DNA: Selection of randomized fingers displayed on phage
    • Choo Y, Klug A. 1994. Toward a code for the interactions of zinc fingers with DNA: Selection of randomized fingers displayed on phage. Proc Natl Acad Sci 91: 11163-11167
    • (1994) Proc Natl Acad Sci , vol.91 , pp. 11163-11167
    • Choo, Y.1    Klug, A.2
  • 32
    • 0028919608 scopus 로고
    • Induction of homologous recombination in mammalian chromo-somes by using the I-SceI system of Saccharomyces cerevisiae
    • Choulika A, Perrin A, Dujon B, Nicolas JF. 1995. Induction of homologous recombination in mammalian chromo-somes by using the I-SceI system of Saccharomyces cerevisiae. Mol Cell Biol 15: 1968-1973
    • (1995) Mol Cell Biol , vol.15 , pp. 1968-1973
    • Choulika, A.1    Perrin, A.2    Dujon, B.3    Nicolas, J.F.4
  • 34
    • 84864856835 scopus 로고    scopus 로고
    • Comprehensive interrogation of natural TALE DNA-binding modules and transcriptional repressor domains
    • Cong L, Zhou R, Kuo YC, Cunniff M, Zhang F. 2012. Comprehensive interrogation of natural TALE DNA-binding modules and transcriptional repressor domains. Nat Commun 3: 968.
    • (2012) Nat Commun , vol.3 , pp. 968
    • Cong, L.1    Zhou, R.2    Kuo, Y.C.3    Cunniff, M.4    Zhang, F.5
  • 36
    • 84957678716 scopus 로고    scopus 로고
    • A transcription activator-like effector (TALE) induction system mediated by proteolysis
    • Copeland MF, Politz MC, Johnson CB, Markley AL, Pfleger BF. 2016. A transcription activator-like effector (TALE) induction system mediated by proteolysis. Nat Chem Biol 12: 254-260
    • (2016) Nat Chem Biol , vol.12 , pp. 254-260
    • Copeland, M.F.1    Politz, M.C.2    Johnson, C.B.3    Markley, A.L.4    Pfleger, B.F.5
  • 37
    • 84923106217 scopus 로고    scopus 로고
    • Therapeutic genome editing: Prospects and challenges
    • Cox DB, Platt RJ, Zhang F. 2015. Therapeutic genome editing: Prospects and challenges. Nat Med 21: 121-131
    • (2015) Nat Med , vol.21 , pp. 121-131
    • Cox, D.B.1    Platt, R.J.2    Zhang, F.3
  • 38
    • 84884950106 scopus 로고    scopus 로고
    • CRISPR/Cas9 systems targeting b-globin and CCR5 genes have substantial off-target activity
    • Cradick TJ, Fine EJ, Antico CJ, Bao G. 2013. CRISPR/Cas9 systems targeting b-globin and CCR5 genes have substantial off-target activity. Nucleic Acids Res 41: 9584-9592
    • (2013) Nucleic Acids Res , vol.41 , pp. 9584-9592
    • Cradick, T.J.1    Fine, E.J.2    Antico, C.J.3    Bao, G.4
  • 41
    • 84937764361 scopus 로고    scopus 로고
    • Small molecule-triggered Cas9 protein with improved genome-editing specificity
    • Davis KM, Pattanayak V, Thompson DB, Zuris JA, Liu DR. 2015. Small molecule-triggered Cas9 protein with improved genome-editing specificity. Nat Chem Biol 11: 316-318
    • (2015) Nat Chem Biol , vol.11 , pp. 316-318
    • Davis, K.M.1    Pattanayak, V.2    Thompson, D.B.3    Zuris, J.A.4    Liu, D.R.5
  • 42
    • 84857032466 scopus 로고    scopus 로고
    • Structural basis for sequence-specific recognition of DNA by TAL effectors
    • Deng D, Yan C, Pan X, Mahfouz M, Wang J, Zhu JK, Shi Y, Yan N. 2012. Structural basis for sequence-specific recognition of DNA by TAL effectors. Science 335: 720-723
    • (2012) Science , vol.335 , pp. 720-723
    • Deng, D.1    Yan, C.2    Pan, X.3    Mahfouz, M.4    Wang, J.5    Zhu, J.K.6    Shi, Y.7    Yan, N.8
  • 46
    • 0035800769 scopus 로고    scopus 로고
    • Development of zinc finger domains for recognition of the 50-ANN-30 family ofDNA sequences and their use in the construction of artificial transcription factors
    • Dreier B, Beerli RR, Segal DJ, Flippin JD, Barbas CF III 2001. Development of zinc finger domains for recognition of the 50-ANN-30 family ofDNA sequences and their use in the construction of artificial transcription factors. J Biol Chem 276: 29466-29478
    • (2001) J Biol Chem , vol.276 , pp. 29466-29478
    • Dreier, B.1    Beerli, R.R.2    Segal, D.J.3    Flippin, J.D.4    Barbas, C.F.5
  • 47
    • 27444444925 scopus 로고    scopus 로고
    • Development of zinc finger domains for recognition of the 50-CNN-30 family DNA sequences and their use in the construction of artificial transcription factors
    • Dreier B, Fuller RP, Segal DJ, Lund CV, Blancafort P, Huber A, Koksch B, Barbas CF III 2005. Development of zinc finger domains for recognition of the 50-CNN-30 family DNA sequences and their use in the construction of artificial transcription factors. J Biol Chem 280: 35588-35597
    • (2005) J Biol Chem , vol.280 , pp. 35588-35597
    • Dreier, B.1    Fuller, R.P.2    Segal, D.J.3    Lund, C.V.4    Blancafort, P.5    Huber, A.6    Koksch, B.7    Barbas, C.F.8
  • 48
    • 33644774584 scopus 로고    scopus 로고
    • Inhibition of human immunodeficiency virus type 1 replication with artificial transcription factors targeting the highly conserved primer-binding site
    • Eberhardy SR, Goncalves J, Coelho S, Segal DJ, Berkhout B, Barbas CF III. 2006. Inhibition of human immunodeficiency virus type 1 replication with artificial transcription factors targeting the highly conserved primer-binding site. J Virol 80: 2873-2883
    • (2006) J Virol , vol.80 , pp. 2873-2883
    • Eberhardy, S.R.1    Goncalves, J.2    Coelho, S.3    Segal, D.J.4    Berkhout, B.5    Barbas, C.6
  • 50
    • 84924410016 scopus 로고    scopus 로고
    • Concerning RNA-guided gene drives for the alteration of wild populations
    • Esvelt KM, Smidler AL, Catteruccia F, Church GM. 2014. Concerning RNA-guided gene drives for the alteration of wild populations. eLife doi: 10.7554/eLife.03401.
    • (2014) Elife
    • Esvelt, K.M.1    Smidler, A.L.2    Catteruccia, F.3    Church, G.M.4
  • 51
    • 84886488970 scopus 로고    scopus 로고
    • Tunable and multifunctional eukaryotic transcription factors based on CRISPR/Cas
    • Farzadfard F, Perli SD, Lu TK. 2013. Tunable and multifunctional eukaryotic transcription factors based on CRISPR/Cas. ACS Synth Biol 2: 604-613
    • (2013) ACS Synth Biol , vol.2 , pp. 604-613
    • Farzadfard, F.1    Perli, S.D.2    Lu, T.K.3
  • 52
    • 84907257107 scopus 로고    scopus 로고
    • Saturation editing of genomic regions by multiplex homology-directed repair
    • Findlay GM, Boyle EA, Hause RJ, Klein JC, Shendure J. 2014. Saturation editing of genomic regions by multiplex homology-directed repair. Nature 513: 120-123
    • (2014) Nature , vol.513 , pp. 120-123
    • Findlay, G.M.1    Boyle, E.A.2    Hause, R.J.3    Klein, J.C.4    Shendure, J.5
  • 54
    • 84896929630 scopus 로고    scopus 로고
    • Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
    • Fu Y, Sander JD, Reyon D, Cascio VM, Joung JK. 2014. Improving CRISPR-Cas nuclease specificity using truncated guide RNAs. Nat Biotechnol 32: 279-284
    • (2014) Nat Biotechnol , vol.32 , pp. 279-284
    • Fu, Y.1    Sander, J.D.2    Reyon, D.3    Cascio, V.M.4    Joung, J.K.5
  • 57
    • 84864439768 scopus 로고    scopus 로고
    • Targeted gene knockout by direct delivery of zinc-finger nuclease proteins
    • Gaj T, Guo J, Kato Y, Sirk SJ, Barbas CF III 2012. Targeted gene knockout by direct delivery of zinc-finger nuclease proteins. Nat Methods 9: 805-807
    • (2012) Nat Methods , vol.9 , pp. 805-807
    • Gaj, T.1    Guo, J.2    Kato, Y.3    Sirk, S.J.4    Barbas, C.F.5
  • 58
    • 84876027225 scopus 로고    scopus 로고
    • A comprehensive approach to zinc-finger recombinase customization enables genomic targeting in human cells
    • Gaj T, Mercer AC, Sirk SJ, Smith HL, Barbas CF III 2013. A comprehensive approach to zinc-finger recombinase customization enables genomic targeting in human cells. Nucleic Acids Res 41: 3937-3946
    • (2013) Nucleic Acids Res , vol.41 , pp. 3937-3946
    • Gaj, T.1    Mercer, A.C.2    Sirk, S.J.3    Smith, H.L.4    Barbas, C.F.5
  • 59
  • 60
    • 84897528479 scopus 로고    scopus 로고
    • Enhancing the specificity of recombinase-mediated genome engineering through dimer interface redesign
    • Gaj T, Sirk SJ, Tingle RD, Mercer AC, Wallen MC, Barbas CF III 2014b. Enhancing the specificity of recombinase-mediated genome engineering through dimer interface redesign. J Am Chem Soc 136: 5047-5056
    • (2014) J am Chem Soc , vol.136 , pp. 5047-5056
    • Gaj, T.1    Sirk, S.J.2    Tingle, R.D.3    Mercer, A.C.4    Wallen, M.C.5    Barbas, C.F.6
  • 61
    • 84960366869 scopus 로고    scopus 로고
    • Genome engineering using adeno-associated virus: Basic and clinical research applications
    • Gaj T, Epstein BE, Schaffer DV. 2016. Genome engineering using adeno-associated virus: Basic and clinical research applications. Mol Ther 24: 458-464
    • (2016) Mol Ther , vol.24 , pp. 458-464
    • Gaj, T.1    Epstein, B.E.2    Schaffer, D.V.3
  • 62
    • 84928208828 scopus 로고    scopus 로고
    • The mutagenic chain reaction: A method for converting heterozygous to homozygous mutations
    • Gantz VM, Bier E. 2015. The mutagenic chain reaction: A method for converting heterozygous to homozygous mutations. Science 348: 442-444
    • (2015) Science , vol.348 , pp. 442-444
    • Gantz, V.M.1    Bier, E.2
  • 63
    • 84949220605 scopus 로고    scopus 로고
    • Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi
    • Gantz VM, Jasinskiene N, Tatarenkova O, Fazekas A, Macias VM, Bier E, James AA. 2015. Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi. Proc Natl Acad Sci 112: E6736-E6743
    • (2015) Proc Natl Acad Sci , vol.112 , pp. E6736-E6743
    • Gantz, V.M.1    Jasinskiene, N.2    Tatarenkova, O.3    Fazekas, A.4    Macias, V.M.5    Bier, E.6    James, A.A.7
  • 64
    • 84881336110 scopus 로고    scopus 로고
    • Reprogramming to pluripotency using designer TALE transcription factors targeting enhancers
    • Gao X, Yang J, Tsang JC, Ooi J, Wu D, Liu P. 2013. Reprogramming to pluripotency using designer TALE transcription factors targeting enhancers. Stem Cell Rep 1: 183-197
    • (2013) Stem Cell Rep , vol.1 , pp. 183-197
    • Gao, X.1    Yang, J.2    Tsang, J.C.3    Ooi, J.4    Wu, D.5    Liu, P.6
  • 69
    • 13544277695 scopus 로고    scopus 로고
    • Exploring strategies for the design of artificial transcription factors: Targeting sites proximal to known regulatory regions for the induction of g-globin expression and the treatment of sickle cell disease
    • Graslund T, Li X, Magnenat L, Popkov M, Barbas CF III 2005. Exploring strategies for the design of artificial transcription factors: Targeting sites proximal to known regulatory regions for the induction of g-globin expression and the treatment of sickle cell disease. J Biol Chem 280: 3707-3714
    • (2005) J Biol Chem , vol.280 , pp. 3707-3714
    • Graslund, T.1    Li, X.2    Magnenat, L.3    Popkov, M.4    Barbas, C.F.5
  • 70
    • 0031053362 scopus 로고    scopus 로고
    • A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites
    • Greisman HA, Pabo CO. 1997. A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites. Science 275: 657-661
    • (1997) Science , vol.275 , pp. 657-661
    • Greisman, H.A.1    Pabo, C.O.2
  • 71
    • 84897954502 scopus 로고    scopus 로고
    • Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity
    • Guilinger JP, Pattanayak V, Reyon D, Tsai SQ, Sander JD, Joung JK, Liu DR. 2014a. Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity. Nat Methods 11: 429-435
    • (2014) Nat Methods , vol.11 , pp. 429-435
    • Guilinger, J.P.1    Pattanayak, V.2    Reyon, D.3    Tsai, S.Q.4    Sander, J.D.5    Joung, J.K.6    Liu, D.R.7
  • 72
    • 84902210542 scopus 로고    scopus 로고
    • Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification
    • Guilinger JP, Thompson DB, Liu DR. 2014b. Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification. Nat Biotechnol 32: 577-582
    • (2014) Nat Biotechnol , vol.32 , pp. 577-582
    • Guilinger, J.P.1    Thompson, D.B.2    Liu, D.R.3
  • 73
    • 77953702888 scopus 로고    scopus 로고
    • Directed evolution of an enhanced and highly efficient FokI cleavage domain for zinc finger nucleases
    • Guo J, Gaj T, Barbas CF III 2010. Directed evolution of an enhanced and highly efficient FokI cleavage domain for zinc finger nucleases. J Mol Biol 400: 96-107
    • (2010) J Mol Biol , vol.400 , pp. 96-107
    • Guo, J.1    Gaj, T.2    Barbas, C.F.3
  • 79
    • 84893287073 scopus 로고    scopus 로고
    • E-CRISP: Fast CRISPR target site identification
    • Heigwer F, Kerr G, Boutros M. 2014. E-CRISP: Fast CRISPR target site identification. Nat Methods 11: 122-123
    • (2014) Nat Methods , vol.11 , pp. 122-123
    • Heigwer, F.1    Kerr, G.2    Boutros, M.3
  • 81
    • 84942912469 scopus 로고    scopus 로고
    • Enabling functional genomics with genome engineering
    • Hilton IB, Gersbach CA. 2015. Enabling functional genomics with genome engineering. Genome Res 25: 1442-1455
    • (2015) Genome Res , vol.25 , pp. 1442-1455
    • Hilton, I.B.1    Gersbach, C.A.2
  • 87
    • 74249095519 scopus 로고    scopus 로고
    • CRISPR/Cas, the immune system of bacteria and archaea
    • Horvath P, Barrangou R. 2010. CRISPR/Cas, the immune system of bacteria and archaea. Science 327: 167-170
    • (2010) Science , vol.327 , pp. 167-170
    • Horvath, P.1    Barrangou, R.2
  • 90
  • 92
    • 0142091373 scopus 로고    scopus 로고
    • Highly specific zinc finger proteins obtained by directed domain shuffling and cell-based selection
    • Hurt JA, Thibodeau SA, Hirsh AS, Pabo CO, Joung JK. 2003. Highly specific zinc finger proteins obtained by directed domain shuffling and cell-based selection. ProcNatl Acad Sci 100: 12271-12276
    • (2003) Procnatl Acad Sci , vol.100 , pp. 12271-12276
    • Hurt, J.A.1    Thibodeau, S.A.2    Hirsh, A.S.3    Pabo, C.O.4    Joung, J.K.5
  • 94
    • 0034930363 scopus 로고    scopus 로고
    • A rapid, generally applicable method to engineer zinc fingers illustrated by targeting the HIV-1 promoter
    • Isalan M, Klug A, Choo Y. 2001.A rapid, generally applicable method to engineer zinc fingers illustrated by targeting the HIV-1 promoter. Nat Biotechnol 19: 656-660
    • (2001) Nat Biotechnol , vol.19 , pp. 656-660
    • Isalan, M.1    Klug, A.2    Choo, Y.3
  • 97
    • 0028227930 scopus 로고
    • In vitro selection of zinc fingers with altered DNA-binding specificity
    • Jamieson AC, Kim SH, Wells JA. 1994. In vitro selection of zinc fingers with altered DNA-binding specificity. Biochemistry 33: 5689-5695
    • (1994) Biochemistry , vol.33 , pp. 5689-5695
    • Jamieson, A.C.1    Kim, S.H.2    Wells, J.A.3
  • 98
    • 84960347655 scopus 로고    scopus 로고
    • Specific reactivation of latent HIV-1 by dCas9-SunTag-VP64-mediated guide RNA targeting the HIV-1 promoter
    • Ji H, Jiang Z, Lu P, Ma L, Li C, Pan H, Fu Z, Qu X, Wang P, Deng J, et al. 2016. Specific reactivation of latent HIV-1 by dCas9-SunTag-VP64-mediated guide RNA targeting the HIV-1 promoter. Mol Ther 24: 508-521
    • (2016) Mol Ther , vol.24 , pp. 508-521
    • Ji, H.1    Jiang, Z.2    Lu, P.3    Ma, L.4    Li, C.5    Pan, H.6    Fu, Z.7    Qu, X.8    Wang, P.9    Deng, J.10
  • 99
  • 101
  • 105
    • 0030032063 scopus 로고    scopus 로고
    • Hybrid restriction enzymes: Zinc finger fusions to Fok I cleavage domain
    • Kim YG, Cha J, Chandrasegaran S. 1996. Hybrid restriction enzymes: Zinc finger fusions to Fok I cleavage domain. Proc Natl Acad Sci 93: 1156-1160
    • (1996) Proc Natl Acad Sci , vol.93 , pp. 1156-1160
    • Kim, Y.G.1    Cha, J.2    Chandrasegaran, S.3
  • 106
    • 67650045497 scopus 로고    scopus 로고
    • Targeted genome editing in human cells with zinc finger nucleases constructed via modular assembly
    • Kim HJ, Lee HJ, Kim H, Cho SW, Kim JS. 2009. Targeted genome editing in human cells with zinc finger nucleases constructed via modular assembly. Genome Res 19: 1279-1288
    • (2009) Genome Res , vol.19 , pp. 1279-1288
    • Kim, H.J.1    Lee, H.J.2    Kim, H.3    Cho, S.W.4    Kim, J.S.5
  • 107
    • 84861990434 scopus 로고    scopus 로고
    • Precision genome engineering with programmable DNA-nicking enzymes
    • Kim E, Kim S, Kim DH, Choi BS, Choi IY, Kim JS. 2012. Precision genome engineering with programmable DNA-nicking enzymes. Genome Res 22: 1327-1333
    • (2012) Genome Res , vol.22 , pp. 1327-1333
    • Kim, E.1    Kim, S.2    Kim, D.H.3    Choi, B.S.4    Choi, I.Y.5    Kim, J.S.6
  • 110
    • 84901834420 scopus 로고    scopus 로고
    • Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins
    • Kim S, Kim D, Cho SW, Kim J, Kim JS. 2014. Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins. Genome Res 24: 1012-1019
    • (2014) Genome Res , vol.24 , pp. 1012-1019
    • Kim, S.1    Kim, D.2    Cho, S.W.3    Kim, J.4    Kim, J.S.5
  • 113
    • 84898665052 scopus 로고    scopus 로고
    • Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library
    • Koike-Yusa H, Li Y, Tan EP, Velasco-HerreraMdel C, Yusa K. 2014. Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library. Nat Biotechnol 32: 267-273
    • (2014) Nat Biotechnol , vol.32 , pp. 267-273
    • Koike-Yusa, H.1    Li, Y.2    Tan, E.P.3    Velasco-Herreramdel, C.4    Yusa, K.5
  • 114
    • 84971006562 scopus 로고    scopus 로고
    • Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
    • Komor AC, Kim YB, Packer MS, Zuris JA, Liu DR. 2016. Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage. Nature doi: 10.1038/nature17946.
    • (2016) Nature
    • Komor, A.C.1    Kim, Y.B.2    Packer, M.S.3    Zuris, J.A.4    Liu, D.R.5
  • 119
    • 74949133880 scopus 로고    scopus 로고
    • Targeted chromosomal deletions in human cells using zinc finger nucleases
    • Lee HJ, Kim E, Kim JS. 2010. Targeted chromosomal deletions in human cells using zinc finger nucleases. Genome Res 20: 81-89
    • (2010) Genome Res , vol.20 , pp. 81-89
    • Lee, H.J.1    Kim, E.2    Kim, J.S.3
  • 121
    • 84870786425 scopus 로고    scopus 로고
    • Transcription activator-like effector hybrids for conditional control and rewiring of chromosomal transgene expression
    • Li Y, Moore R, Guinn M, Bleris L. 2012. Transcription activator-like effector hybrids for conditional control and rewiring of chromosomal transgene expression. Sci Rep 2: 897.
    • (2012) Sci Rep , vol.2 , pp. 897
    • Li, Y.1    Moore, R.2    Guinn, M.3    Bleris, L.4
  • 122
    • 84883779087 scopus 로고    scopus 로고
    • Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems
    • Li W, Teng F, Li T, Zhou Q. 2013. Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems. Nat Biotechnol 31: 684-686
    • (2013) Nat Biotechnol , vol.31 , pp. 684-686
    • Li, W.1    Teng, F.2    Li, T.3    Zhou, Q.4
  • 123
    • 84960423988 scopus 로고    scopus 로고
    • CRISPR-mediated activation of latent HIV-1 expression
    • Limsirichai P, Gaj T, Schaffer DV. 2016. CRISPR-mediated activation of latent HIV-1 expression. Mol Ther 24: 499-507
    • (2016) Mol Ther , vol.24 , pp. 499-507
    • Limsirichai, P.1    Gaj, T.2    Schaffer, D.V.3
  • 125
    • 84941041246 scopus 로고    scopus 로고
    • Creating a monomeric endonuclease TALE-I-SceI with high specificity and low genotoxicity in human cells
    • Lin J, Chen H, Luo L, Lai Y, Xie W, Kee K. 2015a. Creating a monomeric endonuclease TALE-I-SceI with high specificity and low genotoxicity in human cells. Nucleic Acids Res 43: 1112-1122
    • (2015) Nucleic Acids Res , vol.43 , pp. 1112-1122
    • Lin, J.1    Chen, H.2    Luo, L.3    Lai, Y.4    Xie, W.5    Kee, K.6
  • 126
    • 84943638166 scopus 로고    scopus 로고
    • In vivo transcriptional activation using CRISPR/Cas9 in Drosophila
    • Lin S, Ewen-Campen B, Ni X, Housden BE, Perrimon N. 2015b. In vivo transcriptional activation using CRISPR/Cas9 in Drosophila. Genetics 201: 433-442
    • (2015) Genetics , vol.201 , pp. 433-442
    • Lin, S.1    Ewen-Campen, B.2    Ni, X.3    Housden, B.E.4    Perrimon, N.5
  • 127
    • 0030903688 scopus 로고    scopus 로고
    • Design of polydactyl zinc-finger proteins for unique addressing within complex genomes
    • Liu Q, Segal DJ, Ghiara JB, Barbas CF III. 1997. Design of polydactyl zinc-finger proteins for unique addressing within complex genomes. Proc Natl Acad Sci 94: 5525-5530
    • (1997) Proc Natl Acad Sci , vol.94 , pp. 5525-5530
    • Liu, Q.1    Segal, D.J.2    Ghiara, J.B.3    Barbas, C.4
  • 128
    • 84901838361 scopus 로고    scopus 로고
    • Cellpenetrating peptide-mediated delivery of TALEN proteins via bioconjugation for genome engineering
    • Liu J, Gaj T, Patterson JT, Sirk SJ, Barbas CF III. 2014a. Cellpenetrating peptide-mediated delivery of TALEN proteins via bioconjugation for genome engineering. PLoS ONE 9: e85755.
    • (2014) Plos ONE , pp. 9
    • Liu, J.1    Gaj, T.2    Patterson, J.T.3    Sirk, S.J.4    Barbas, C.5
  • 129
    • 84923226022 scopus 로고    scopus 로고
    • Synthesizing AND gate genetic circuits based on CRISPR-Cas9 for identification of bladder cancer cells
    • Liu Y, Zeng Y, Liu L, Zhuang C, Fu X, Huang W, Cai Z. 2014b. Synthesizing AND gate genetic circuits based on CRISPR-Cas9 for identification of bladder cancer cells. Nat Commun 5: 5393.
    • (2014) Nat Commun , vol.5 , pp. 5393
    • Liu, Y.1    Zeng, Y.2    Liu, L.3    Zhuang, C.4    Fu, X.5    Huang, W.6    Cai, Z.7
  • 131
    • 84940665874 scopus 로고    scopus 로고
    • Improved cellpenetrating zinc-finger nuclease proteins for precision genome engineering
    • Liu J, Gaj T, Wallen MC, Barbas CF III 2015a. Improved cellpenetrating zinc-finger nuclease proteins for precision genome engineering. Mol Ther Nucleic Acids 4: e232.
    • (2015) Mol Ther Nucleic Acids , pp. 4
    • Liu, J.1    Gaj, T.2    Wallen, M.C.3    Barbas, C.F.4
  • 134
    • 84965034230 scopus 로고    scopus 로고
    • Locked and proteolysis-based transcription activator-like effector (TALE) regulation
    • Lonzaric J, Lebar T, Majerle A, Mancek-Keber M, Jerala R. 2016. Locked and proteolysis-based transcription activator-like effector (TALE) regulation. Nucleic Acids Res 44: 1471-1481
    • (2016) Nucleic Acids Res , vol.44 , pp. 1471-1481
    • Lonzaric, J.1    Lebar, T.2    Majerle, A.3    Mancek-Keber, M.4    Jerala, R.5
  • 137
    • 84960431733 scopus 로고    scopus 로고
    • Genome-editing technologies for gene and cell therapy
    • Maeder ML, Gersbach CA. 2016. Genome-editing technologies for gene and cell therapy. Mol Ther 24: 430-446
    • (2016) Mol Ther , vol.24 , pp. 430-446
    • Maeder, M.L.1    Gersbach, C.A.2
  • 141
    • 84965050620 scopus 로고    scopus 로고
    • Selection-free gene repair after adenoviral vector transduction of designer nucleases: Rescue of dystrophin synthesis in DMD muscle cell populations
    • Maggio I, Stefanucci L, Janssen JM, Liu J, Chen X, Mouly V, Goncalves MA. 2016. Selection-free gene repair after adenoviral vector transduction of designer nucleases: rescue of dystrophin synthesis in DMD muscle cell populations. Nucleic Acids Res 44: 1449-1470
    • (2016) Nucleic Acids Res , vol.44 , pp. 1449-1470
    • Maggio, I.1    Stefanucci, L.2    Janssen, J.M.3    Liu, J.4    Chen, X.5    Mouly, V.6    Goncalves, M.A.7
  • 142
    • 4344685148 scopus 로고    scopus 로고
    • In vivo selection of combinatorial libraries and designed affinity maturation of polydactyl zinc finger transcription factors for ICAM-1 provides new insights into gene regulation
    • Magnenat L, Blancafort P, Barbas CF III 2004. In vivo selection of combinatorial libraries and designed affinity maturation of polydactyl zinc finger transcription factors for ICAM-1 provides new insights into gene regulation. J Mol Biol 341: 635-649
    • (2004) J Mol Biol , vol.341 , pp. 635-649
    • Magnenat, L.1    Blancafort, P.2    Barbas, C.F.3
  • 143
    • 50049095016 scopus 로고    scopus 로고
    • Druginducible and simultaneous regulation of endogenous genes by single-chain nuclear receptor-based zinc-finger transcription factor gene switches
    • Magnenat L, Schwimmer LJ, Barbas CF III 2008. Druginducible and simultaneous regulation of endogenous genes by single-chain nuclear receptor-based zinc-finger transcription factor gene switches. Gene Ther 15: 1223-1232
    • (2008) Gene Ther , vol.15 , pp. 1223-1232
    • Magnenat, L.1    Schwimmer, L.J.2    Barbas, C.F.3
  • 146
    • 84884160273 scopus 로고    scopus 로고
    • CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering
    • Mali P, Aach J, Stranges PB, Esvelt KM, Moosburner M, Kosuri S, Yang L, Church GM. 2013a. CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nat Biotechnol 31: 833-838
    • (2013) Nat Biotechnol , vol.31 , pp. 833-838
    • Mali, P.1    Aach, J.2    Stranges, P.B.3    Esvelt, K.M.4    Moosburner, M.5    Kosuri, S.6    Yang, L.7    Church, G.M.8
  • 149
    • 77249170201 scopus 로고    scopus 로고
    • CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea
    • Marraffini LA, Sontheimer EJ. 2010. CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea. Nat Rev Genet 11: 181-190
    • (2010) Nat Rev Genet , vol.11 , pp. 181-190
    • Marraffini, L.A.1    Sontheimer, E.J.2
  • 150
    • 65249139484 scopus 로고    scopus 로고
    • Generation of a nicking enzyme that stimulates site-specific gene conversion from the I-AniI LAGLIDADG homing endonuclease
    • McConnell Smith A, Takeuchi R, Pellenz S, Davis L, Maizels N, Monnat RJ Jr, Stoddard BL. 2009. Generation of a nicking enzyme that stimulates site-specific gene conversion from the I-AniI LAGLIDADG homing endonuclease. Proc Natl Acad Sci 106: 5099-5104
    • (2009) Proc Natl Acad Sci , vol.106 , pp. 5099-5104
    • McConnell Smith, A.1    Takeuchi, R.2    Pellenz, S.3    Davis, L.4    Maizels, N.5    Monnat, R.J.6    Stoddard, B.L.7
  • 154
    • 84870579235 scopus 로고    scopus 로고
    • Chimeric TALE recombinases with programmable DNA sequence specificity
    • Mercer AC, Gaj T, Fuller RP, Barbas CF III. 2012. Chimeric TALE recombinases with programmable DNA sequence specificity. Nucleic Acids Res 40: 11163-11172
    • (2012) Nucleic Acids Res , vol.40 , pp. 11163-11172
    • Mercer, A.C.1    Gaj, T.2    Fuller, R.P.3    Barbas, C.F.4
  • 155
    • 84908075475 scopus 로고    scopus 로고
    • Regulation of endogenous human gene expression by ligand-inducible TALE transcription factors
    • Mercer AC, Gaj T, Sirk SJ, Lamb BM, Barbas CF III 2014. Regulation of endogenous human gene expression by ligand-inducible TALE transcription factors. ACS Synth Biol 3: 723-730
    • (2014) ACS Synth Biol , vol.3 , pp. 723-730
    • Mercer, A.C.1    Gaj, T.2    Sirk, S.J.3    Lamb, B.M.4    Barbas, C.F.5
  • 159
    • 84936887731 scopus 로고    scopus 로고
    • Fehse B. 2015. mRNA transfection of a novel TAL effector nuclease (TALEN) facilitates efficient knockout of HIV co-receptor CCR5
    • Mock U, Machowicz R, Hauber I, Horn S, Abramowski P, Berdien B, Hauber J, Fehse B. 2015. mRNA transfection of a novel TAL effector nuclease (TALEN) facilitates efficient knockout of HIV co-receptor CCR5. Nucleic Acids Res 43: 5560-5571
    • Nucleic Acids Res , vol.43 , pp. 5560-5571
    • Mock, U.1    Machowicz, R.2    Hauber, I.3    Horn, S.4    Abramowski, P.5    Berdien, B.6    Hauber, J.7
  • 161
    • 72149090954 scopus 로고    scopus 로고
    • A simple cipher governs DNA recognition by TAL effectors
    • Moscou MJ, Bogdanove AJ. 2009. A simple cipher governs DNA recognition by TAL effectors. Science 326: 1501.
    • (2009) Science , vol.326 , pp. 1501
    • Moscou, M.J.1    Bogdanove, A.J.2
  • 164
    • 84934936070 scopus 로고    scopus 로고
    • Multi-input CRISPR/Cas genetic circuits that interface host regulatory networks
    • Nielsen AA, Voigt CA. 2014. Multi-input CRISPR/Cas genetic circuits that interface host regulatory networks. Mol Syst Biol 10: 763.
    • (2014) Mol Syst Biol , vol.10 , pp. 763
    • Nielsen, A.A.1    Voigt, C.A.2
  • 167
    • 84901195977 scopus 로고    scopus 로고
    • Multiplexed and programmable regulation of gene networks with an integrated RNA and CRISPR/Cas toolkit in human cells
    • Nissim L, Perli SD, Fridkin A, Perez-Pinera P, Lu TK. 2014. Multiplexed and programmable regulation of gene networks with an integrated RNA and CRISPR/Cas toolkit in human cells. Mol Cell 54: 698-710
    • (2014) Mol Cell , vol.54 , pp. 698-710
    • Nissim, L.1    Perli, S.D.2    Fridkin, A.3    Perez-Pinera, P.4    Lu, T.K.5
  • 169
    • 84941248689 scopus 로고    scopus 로고
    • High efficiency, homology-directed genome editing in Caenorhabditis elegans using CRISPR-Cas9 ribonucleoprotein complexes
    • Paix A, Folkmann A, Rasoloson D, Seydoux G. 2015. High efficiency, homology-directed genome editing in Caenorhabditis elegans using CRISPR-Cas9 ribonucleoprotein complexes. Genetics 201: 47-54
    • (2015) Genetics , vol.201 , pp. 47-54
    • Paix, A.1    Folkmann, A.2    Rasoloson, D.3    Seydoux, G.4
  • 170
    • 0037452614 scopus 로고    scopus 로고
    • Inhibition of herpes simplex virus 1 gene expression by designer zinc-finger transcription factors
    • Papworth M, Moore M, Isalan M, Minczuk M, Choo Y, Klug A. 2003. Inhibition of herpes simplex virus 1 gene expression by designer zinc-finger transcription factors. Proc Natl Acad Sci 100: 1621-1626
    • (2003) Proc Natl Acad Sci , vol.100 , pp. 1621-1626
    • Papworth, M.1    Moore, M.2    Isalan, M.3    Minczuk, M.4    Choo, Y.5    Klug, A.6
  • 173
    • 80052293623 scopus 로고    scopus 로고
    • Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection
    • Pattanayak V, Ramirez CL, Joung JK, Liu DR. 2011. Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection. Nat Methods 8: 765-770
    • (2011) Nat Methods , vol.8 , pp. 765-770
    • Pattanayak, V.1    Ramirez, C.L.2    Joung, J.K.3    Liu, D.R.4
  • 174
    • 0025773296 scopus 로고
    • Zinc finger-DNA recognition: Crystal structure of a Zif268-DNA complex at 2.1 A
    • Pavletich NP, Pabo CO. 1991. Zinc finger-DNA recognition: Crystal structure of a Zif268-DNA complex at 2.1 A. Science 252: 809-817
    • (1991) Science , vol.252 , pp. 809-817
    • Pavletich, N.P.1    Pabo, C.O.2
  • 175
    • 84962315127 scopus 로고    scopus 로고
    • Reactivation of latent HIV-1 expression by engineered TALE transcription factors
    • Perdigao P, Gaj T, Santa-Marta M, Barbas CF III, Goncalves J. 2016. Reactivation of latent HIV-1 expression by engineered TALE transcription factors. PLoS ONE 11: e0150037.
    • (2016) Plos ONE , pp. 11
    • Perdigao, P.1    Gaj, T.2    Santa-Marta, M.3    Barbas, C.4    Goncalves, J.5
  • 179
    • 0035989652 scopus 로고    scopus 로고
    • Regulation of endogenous gene expression with a small-molecule dimerizer
    • Pollock R, Giel M, Linher K, Clackson T. 2002. Regulation of endogenous gene expression with a small-molecule dimerizer. Nat Biotechnol 20: 729-733
    • (2002) Nat Biotechnol , vol.20 , pp. 729-733
    • Pollock, R.1    Giel, M.2    Linher, K.3    Clackson, T.4
  • 180
    • 84867370333 scopus 로고    scopus 로고
    • Light-inducible spatiotemporal control of gene activation by customizable zinc finger transcription factors
    • Polstein LR, Gersbach CA. 2012. Light-inducible spatiotemporal control of gene activation by customizable zinc finger transcription factors. J Am Chem Soc 134: 16480-16483
    • (2012) J am Chem Soc , vol.134 , pp. 16480-16483
    • Polstein, L.R.1    Gersbach, C.A.2
  • 181
    • 84925534357 scopus 로고    scopus 로고
    • A light-inducible CRISPRCas9 system for control of endogenous gene activation
    • Polstein LR, Gersbach CA. 2015. A light-inducible CRISPRCas9 system for control of endogenous gene activation. Nat Chem Biol 11: 198-200
    • (2015) Nat Chem Biol , vol.11 , pp. 198-200
    • Polstein, L.R.1    Gersbach, C.A.2
  • 182
    • 84951813219 scopus 로고    scopus 로고
    • Towards a new era in medicine: Therapeutic genome editing
    • Porteus MH. 2015. Towards a new era in medicine: Therapeutic genome editing. Genome Biol 16: 286.
    • (2015) Genome Biol , vol.16 , pp. 286
    • Porteus, M.H.1
  • 183
    • 0038523969 scopus 로고    scopus 로고
    • Chimeric nucleases stimulate gene targeting in human cells
    • Porteus MH, Baltimore D. 2003. Chimeric nucleases stimulate gene targeting in human cells. Science 300: 763.
    • (2003) Science , vol.300 , pp. 763
    • Porteus, M.H.1    Baltimore, D.2
  • 184
    • 23444441147 scopus 로고    scopus 로고
    • Gene targeting using zinc finger nucleases
    • Porteus MH, Carroll D. 2005. Gene targeting using zinc finger nucleases. Nat Biotechnol 23: 967-973
    • (2005) Nat Biotechnol , vol.23 , pp. 967-973
    • Porteus, M.H.1    Carroll, D.2
  • 185
    • 61449266636 scopus 로고    scopus 로고
    • Attenuation of zinc finger nuclease toxicity by small-molecule regulation of protein levels
    • Pruett-Miller SM, Reading DW, Porter SN, Porteus MH. 2009. Attenuation of zinc finger nuclease toxicity by small-molecule regulation of protein levels. PLoS Genet 5: e1000376.
    • (2009) Plos Genet , pp. 5
    • Pruett-Miller, S.M.1    Reading, D.W.2    Porter, S.N.3    Porteus, M.H.4
  • 186
    • 84874687019 scopus 로고    scopus 로고
    • Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression
    • Qi LS, Larson MH, Gilbert LA, Doudna JA, Weissman JS, Arkin AP, Lim WA. 2013. Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell 152: 1173-1183
    • (2013) Cell , vol.152 , pp. 1173-1183
    • Qi, L.S.1    Larson, M.H.2    Gilbert, L.A.3    Doudna, J.A.4    Weissman, J.S.5    Arkin, A.P.6    Lim, W.A.7
  • 192
    • 0037452693 scopus 로고    scopus 로고
    • Repression of the HIV-1 50 LTR promoter and inhibition of HIV-1 replication by using engineered zinc-finger transcription factors
    • Reynolds L, Ullman C, Moore M, Isalan M, West MJ, Clapham P, Klug A, Choo Y. 2003. Repression of the HIV-1 50 LTR promoter and inhibition of HIV-1 replication by using engineered zinc-finger transcription factors. Proc Natl Acad Sci 100: 1615-1620
    • (2003) Proc Natl Acad Sci , vol.100 , pp. 1615-1620
    • Reynolds, L.1    Ullman, C.2    Moore, M.3    Isalan, M.4    West, M.J.5    Clapham, P.6    Klug, A.7    Choo, Y.8
  • 195
    • 0028061666 scopus 로고
    • Introduction of doublestrand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease
    • Rouet P, Smih F, Jasin M. 1994. Introduction of doublestrand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease. Mol Cell Biol 14: 8096-8106
    • (1994) Mol Cell Biol , vol.14 , pp. 8096-8106
    • Rouet, P.1    Smih, F.2    Jasin, M.3
  • 198
    • 0023697252 scopus 로고
    • GAL4-VP16 is an unusually potent transcriptional activator
    • Sadowski I, Ma J, Triezenberg S, Ptashne M. 1988. GAL4-VP16 is an unusually potent transcriptional activator. Nature 335: 563-564
    • (1988) Nature , vol.335 , pp. 563-564
    • Sadowski, I.1    Ma, J.2    Triezenberg, S.3    Ptashne, M.4
  • 203
    • 84872203111 scopus 로고    scopus 로고
    • A ligation-independent cloning technique for high-throughput assembly of transcription activatorlike effector genes
    • Schmid-Burgk JL, Schmidt T, Kaiser V, Honing K, Hornung V. 2013. A ligation-independent cloning technique for high-throughput assembly of transcription activatorlike effector genes. Nat Biotechnol 31: 76-81
    • (2013) Nat Biotechnol , vol.31 , pp. 76-81
    • Schmid-Burgk, J.L.1    Schmidt, T.2    Kaiser, V.3    Honing, K.4    Hornung, V.5
  • 205
    • 0032981699 scopus 로고    scopus 로고
    • Toward controlling gene expression at will: Selection and design of zinc finger domains recognizing each of the 50-GNN-30 DNAtarget sequences
    • Segal DJ, Dreier B, Beerli RR, Barbas CF III 1999. Toward controlling gene expression at will: Selection and design of zinc finger domains recognizing each of the 50-GNN-30 DNAtarget sequences. ProcNatl Acad Sci 96: 2758-2763
    • (1999) Procnatl Acad Sci , vol.96 , pp. 2758-2763
    • Segal, D.J.1    Dreier, B.2    Beerli, R.R.3    Barbas, C.F.4
  • 206
    • 2442536906 scopus 로고    scopus 로고
    • Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor
    • Segal DJ, Goncalves J, Eberhardy S, Swan CH, Torbett BE, Li X, Barbas CF III 2004. Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor. J Biol Chem 279: 14509-14519
    • (2004) J Biol Chem , vol.279 , pp. 14509-14519
    • Segal, D.J.1    Goncalves, J.2    Eberhardy, S.3    Swan, C.H.4    Torbett, B.E.5    Li, X.6    Barbas, C.F.7
  • 210
    • 84872865881 scopus 로고    scopus 로고
    • Targeted methylation and gene silencing of VEGF-A in human cells by using a designed Dnmt3a-Dnmt3L single-chain fusion protein with increased DNA methylation activity
    • Siddique AN, Nunna S, Rajavelu A, Zhang Y, Jurkowska RZ, Reinhardt R, Rots MG, Ragozin S, Jurkowski TP, Jeltsch A. 2013. Targeted methylation and gene silencing of VEGF-A in human cells by using a designed Dnmt3a-Dnmt3L single-chain fusion protein with increased DNA methylation activity. J Mol Biol 425: 479-491
    • (2013) J Mol Biol , vol.425 , pp. 479-491
    • Siddique, A.N.1    Nunna, S.2    Rajavelu, A.3    Zhang, Y.4    Jurkowska, R.Z.5    Reinhardt, R.6    Rots, M.G.7    Ragozin, S.8    Jurkowski, T.P.9    Jeltsch, A.10
  • 211
    • 79951694132 scopus 로고    scopus 로고
    • Meganucleases and other tools for targeted genome engineering: Perspectives and challenges for gene therapy
    • Silva G, Poirot L, Galetto R, Smith J, Montoya G, Duchateau P, Paques F. 2011. Meganucleases and other tools for targeted genome engineering: perspectives and challenges for gene therapy. Curr Gene Ther 11: 11-27
    • (2011) Curr Gene Ther , vol.11 , pp. 11-27
    • Silva, G.1    Poirot, L.2    Galetto, R.3    Smith, J.4    Montoya, G.5    Duchateau, P.6    Paques, F.7
  • 212
    • 33646882131 scopus 로고    scopus 로고
    • Gene drive systems for insect disease vectors
    • Sinkins SP, Gould F. 2006. Gene drive systems for insect disease vectors. Nat Rev Genet 7: 427-435
    • (2006) Nat Rev Genet , vol.7 , pp. 427-435
    • Sinkins, S.P.1    Gould, F.2
  • 213
    • 84899027573 scopus 로고    scopus 로고
    • Expanding the zinc-finger recombinase repertoire: Directed evolution and mutational analysis of serine recombinase specificity determinants
    • Sirk SJ, Gaj T, Jonsson A, Mercer AC, Barbas CF III 2014. Expanding the zinc-finger recombinase repertoire: Directed evolution and mutational analysis of serine recombinase specificity determinants. Nucleic Acids Res 42: 4755-4766
    • (2014) Nucleic Acids Res , vol.42 , pp. 4755-4766
    • Sirk, S.J.1    Gaj, T.2    Jonsson, A.3    Mercer, A.C.4    Barbas, C.F.5
  • 215
    • 0034283804 scopus 로고    scopus 로고
    • Requirements for double-strand cleavage by chimeric restriction enzymes with zinc finger DNA-recognition domains
    • Smith J, Bibikova M, Whitby FG, Reddy AR, Chandrasegaran S, Carroll D. 2000. Requirements for double-strand cleavage by chimeric restriction enzymes with zinc finger DNA-recognition domains. Nucleic Acids Res 28: 3361-3369
    • (2000) Nucleic Acids Res , vol.28 , pp. 3361-3369
    • Smith, J.1    Bibikova, M.2    Whitby, F.G.3    Reddy, A.R.4    Chandrasegaran, S.5    Carroll, D.6
  • 216
    • 84878936806 scopus 로고    scopus 로고
    • CRISPR-mediated adaptive immune systems in bacteria and archaea
    • Sorek R, Lawrence CM, Wiedenheft B. 2013. CRISPR-mediated adaptive immune systems in bacteria and archaea. Annu Rev Biochem 82: 237-266
    • (2013) Annu Rev Biochem , vol.82 , pp. 237-266
    • Sorek, R.1    Lawrence, C.M.2    Wiedenheft, B.3
  • 217
    • 78651240053 scopus 로고    scopus 로고
    • Homing endonucleases: Frommicrobial genetic invaders to reagents for targeted DNA modification
    • Stoddard BL. 2011.Homing endonucleases: Frommicrobial genetic invaders to reagents for targeted DNA modification. Structure 19: 7-15
    • (2011) Structure , vol.19 , pp. 7-15
    • Stoddard, B.L.1
  • 218
    • 84896766709 scopus 로고    scopus 로고
    • Homing endonucleases from mobile group I introns: Discovery to genome engineering
    • Stoddard BL. 2014. Homing endonucleases from mobile group I introns: Discovery to genome engineering. Mob DNA 5: 7.
    • (2014) Mob DNA , vol.5 , pp. 7
    • Stoddard, B.L.1
  • 230
    • 84946962329 scopus 로고    scopus 로고
    • Redesigning recombinase specificity for safe harbor sites in the human genome
    • Wallen MC, Gaj T, Barbas CF III 2015. Redesigning recombinase specificity for safe harbor sites in the human genome. PLoS ONE 10: e0139123.
    • (2015) Plos ONE , pp. 10
    • Wallen, M.C.1    Gaj, T.2    Barbas, C.F.3
  • 233
    • 84892749369 scopus 로고    scopus 로고
    • Genetic screens in human cells using the CRISPR-Cas9 system
    • Wang T, Wei JJ, Sabatini DM, Lander ES. 2014a. Genetic screens in human cells using the CRISPR-Cas9 system. Science 343: 80-84
    • (2014) Science , vol.343 , pp. 80-84
    • Wang, T.1    Wei, J.J.2    Sabatini, D.M.3    Lander, E.S.4
  • 234
    • 84921934205 scopus 로고    scopus 로고
    • Simultaneous editing of three homoeoalleles in hexaploid bread wheat confers heritable resistance to powdery mildew
    • Wang Y, Cheng X, Shan Q, Zhang Y, Liu J, Gao C, Qiu JL. 2014b. Simultaneous editing of three homoeoalleles in hexaploid bread wheat confers heritable resistance to powdery mildew. Nat Biotechnol 32: 947-951
    • (2014) Nat Biotechnol , vol.32 , pp. 947-951
    • Wang, Y.1    Cheng, X.2    Shan, Q.3    Zhang, Y.4    Liu, J.5    Gao, C.6    Qiu, J.L.7
  • 235
    • 84949211352 scopus 로고    scopus 로고
    • Large genomic fragment deletion and functional gene cassette knock-in via Cas9 protein mediated genome editing in one-cell rodent embryos
    • Wang L, Shao Y, Guan Y, Li L, Wu L, Chen F, Liu M, Chen H, Ma Y, Ma X, et al. 2015a. Large genomic fragment deletion and functional gene cassette knock-in via Cas9 protein mediated genome editing in one-cell rodent embryos. Sci Rep 5: 17517.
    • (2015) Sci Rep , vol.5 , pp. 17517
    • Wang, L.1    Shao, Y.2    Guan, Y.3    Li, L.4    Wu, L.5    Chen, F.6    Liu, M.7    Chen, H.8    Ma, Y.9    Ma, X.10
  • 237
    • 84857097177 scopus 로고    scopus 로고
    • RNA-guided genetic silencing systems in bacteria and archaea
    • Wiedenheft B, Sternberg SH, Doudna JA. 2012. RNA-guided genetic silencing systems in bacteria and archaea. Nature 482: 331-338
    • (2012) Nature , vol.482 , pp. 331-338
    • Wiedenheft, B.1    Sternberg, S.H.2    Doudna, J.A.3
  • 238
    • 77951060091 scopus 로고    scopus 로고
    • A zinc-finger transcriptional activator designed to interact with the g-globin gene promoters enhances fetal hemoglobin production in primary human adult erythroblasts
    • Wilber A, Tschulena U, Hargrove PW, Kim YS, Persons DA, Barbas CF III, Nienhuis AW. 2010. A zinc-finger transcriptional activator designed to interact with the g-globin gene promoters enhances fetal hemoglobin production in primary human adult erythroblasts. Blood 115: 3033-3041
    • (2010) Blood , vol.115 , pp. 3033-3041
    • Wilber, A.1    Tschulena, U.2    Hargrove, P.W.3    Kim, Y.S.4    Persons, D.A.5    Barbas, C.6    Nienhuis, A.W.7
  • 242
    • 0028888530 scopus 로고
    • Building zinc fingers by selection: Toward a therapeutic application
    • Wu H, Yang WP, Barbas CF III 1995. Building zinc fingers by selection: Toward a therapeutic application. Proc Natl Acad Sci 92: 344-348
    • (1995) Proc Natl Acad Sci , vol.92 , pp. 344-348
    • Wu, H.1    Yang, W.P.2    Barbas, C.F.3
  • 244
    • 84961290146 scopus 로고    scopus 로고
    • TALE nickase-mediated SP110 knockin endows cattle with increased resistance to tuberculosis
    • Wu H, Wang Y, Zhang Y, Yang M, Lv J, Liu J, Zhang Y. 2015. TALE nickase-mediated SP110 knockin endows cattle with increased resistance to tuberculosis. Proc Natl Acad Sci 112: E1530-E1539
    • (2015) Proc Natl Acad Sci , vol.112 , pp. E1530-E1539
    • Wu, H.1    Wang, Y.2    Zhang, Y.3    Yang, M.4    Lv, J.5    Liu, J.6    Zhang, Y.7
  • 252
    • 84923297110 scopus 로고    scopus 로고
    • A split-Cas9 architecture for inducible genome editing and transcription modulation
    • Zetsche B, Volz SE, Zhang F. 2015b. A split-Cas9 architecture for inducible genome editing and transcription modulation. Nat Biotechnol 33: 139-142
    • (2015) Nat Biotechnol , vol.33 , pp. 139-142
    • Zetsche, B.1    Volz, S.E.2    Zhang, F.3
  • 253
    • 79751487297 scopus 로고    scopus 로고
    • Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription
    • Zhang F, Cong L, Lodato S, Kosuri S, Church GM, Arlotta P. 2011. Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription. Nat Biotechnol 29: 149-153
    • (2011) Nat Biotechnol , vol.29 , pp. 149-153
    • Zhang, F.1    Cong, L.2    Lodato, S.3    Kosuri, S.4    Church, G.M.5    Arlotta, P.6
  • 254
    • 84947078456 scopus 로고    scopus 로고
    • CRISPR/gRNA-directed synergistic activation mediator (SAM) induces specific, persistent and robust reactivation of the HIV-1 latent reservoirs
    • Zhang Y, Yin C, Zhang T, Li F, Yang W, Kaminski R, Fagan PR, Putatunda R, Young WB, Khalili K, et al. 2015. CRISPR/gRNA-directed synergistic activation mediator (SAM) induces specific, persistent and robust reactivation of the HIV-1 latent reservoirs. Sci Rep 5: 16277.
    • (2015) Sci Rep , vol.5 , pp. 16277
    • Zhang, Y.1    Yin, C.2    Zhang, T.3    Li, F.4    Yang, W.5    Kaminski, R.6    Fagan, P.R.7    Putatunda, R.8    Young, W.B.9    Khalili, K.10
  • 255
    • 84900861730 scopus 로고    scopus 로고
    • High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells
    • Zhou Y, Zhu S, Cai C, Yuan P, Li C, Huang Y, Wei W. 2014. High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells. Nature 509: 487-491
    • (2014) Nature , vol.509 , pp. 487-491
    • Zhou, Y.1    Zhu, S.2    Cai, C.3    Yuan, P.4    Li, C.5    Huang, Y.6    Wei, W.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.