Repression of the HIV-1 5′ LTR promoter and inhibition of HIV-1 replication by using engineered zinc-finger transcription factors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 4, 2003, Pages 1615-1620

  Reynolds, Lindsey ^a   Ullman, Christopher ^a,e   Moore, Michael ^a,b   Isalan, Mark ^a,b,f   West, Michelle J ^c   Clapham, Paul ^d,g   Klug, Aaron ^b   Choo, Yen ^a  

^a Sangamo Biosciences Inc   (United Kingdom)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^c UNIVERSITY OF SUSSEX   (United Kingdom)

^d Windeyer Institute   (United Kingdom)

^e Isogenica Ltd   (United Kingdom)

^f EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^g UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; MITOGENIC AGENT; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SP1; ZINC FINGER PROTEIN;

5' UNTRANSLATED REGION; ARTICLE; BINDING SITE; CONTROLLED STUDY; DNA SEQUENCE; GENE REPRESSION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN ENGINEERING; REPORTER GENE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; VIRUS INHIBITION; VIRUS REPLICATION; ZINC FINGER MOTIF;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; COS CELLS; DNA; HIV LONG TERMINAL REPEAT; HIV-1; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); PROTEIN ENGINEERING; TRANSCRIPTION FACTORS; VIRUS REPLICATION; ZINC FINGERS;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 0037452693     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.252770699     Document Type: Article

References (47)

1. Desjarlais, J. R. & Berg, J. M. (1992) Proc. Natl. Acad. Sci. USA 89, 7345-7349.
2. Desjarlais, J. R. & Berg, J. M. (1993) Proc. Natl. Acad. Sci. USA 90, 2256-2260.
3. Jamieson, A. C., Kim, S. H. & Wells, J. A. (1994) Biochemistry 33, 5689-5695.
4. Rebar, E. J. & Pabo, C. O. (1994) Science 263, 671-673.
5. Choo, Y. & Klug, A. (1994) Proc. Natl. Acad. Sci. USA 91, 11163-11167.
6. Choo, Y. & Klug, A. (1994) Proc. Natl. Acad. Sci. USA 91, 11168-11172.
7. Isalan. M. & Choo, Y. (2001) Methods Enzymol. 340, 593-609.
8. Choo, Y. & Isalan, M. (2000) Curr. Opin. Struct. Biol. 10, 411-416.
9. Pabo, C. O., Peisach, E. & Grant, R. A. (2001) Annu. Rev. Biochem. 70, 313-340.
10. Beerli, R. R. & Barbas, C. F., III (2002) Nat. Biotechnol. 20, 135-141.
11. Greisman, H. A. & Pabo, C. O. (1997) Science 275, 657-661.
12. Isalan, M., Klug, A. & Choo, Y. (2001) Nat. Biotechnol. 19, 656-660.
13. Dreier, B., Beerli, R. R., Segal, D. J., Flippin, J. D. & Barbas, C. F., III (2001) J. Biol. Chem. 276, 29466-29478.
14. Liu, Q., Segal, D. J., Ghiara, J. B. & Barbas, C. F., III (1997) Proc. Natl. Acad. Sci. USA 94, 5525-5530.
15. Kim, J.-S. & Pabo, C. O. (1998) Proc. Natl. Acad. Sci. USA 95, 2812-2817.
16. Wu, H., Yang, W. P. & Barbas, C. F., III (1995) Proc. Natl. Acad. Sci. USA 92, 344-348.
17. Papworth, M., Moore, M., Isalan, M., Minczuk, M., Choo, Y. & Klug, A. (2003) Proc. Natl. Acad. Sci. USA 100, 1621-1626.
18. Cohen, J. (2002) Science 296, 2320-2324.
19. Cohen, J. (2002) Science 296, 2325-2326.
20. Friesen, W. J. & Darby, M. K. (2001) J. Biol. Chem. 276, 1968-1973.
21. McColl, D. J., Honchell, C. D. & Frankel, A. D. (1999) Proc. Natl. Acad. Sci. USA 96, 9521-9526.
22. Zhang, L., Spratt, S. K., Liu, Q., Johnstone, B., Qi, H., Raschke, E. E., Jamieson, A. C., Rebar, E. J., Wolffe, A. P. & Case, C. C. (2000) J. Biol. Chem. 275, 33850-33860.
23. Liu, P. Q., Rebar, E. J., Zhang, L., Liu, Q., Jamieson, A. C., Liang, Y., Qi, H., Li, P. X., Chen, B., Mendel, M. C., et al. (2001) J. Biol. Chem. 276, 11323-11334.
24. Beerli, R. R., Dreier, B. & Barbas, C. F., III (2000) Proc. Natl. Acad. Sci. USA 97, 1495-1500.
25. Ren, D., Collingwood, T. N., Rebar, E. J., Wolffe, A. P. & Camp, H. S. (2002) Genes Dev. 16, 27-32.
26. Herchenroder, O., Hahne, J. C., Meyer, W. K., Thiesen, H. J. & Schneider, J. (1999) Biochim. Biophys. Acta 1445, 216-223.
27. Kirchhoff, F., Greenough, T. C., Hamacher, M., Sullivan, J. L. & Desrosiers, R. C. (1997) Virology 232, 319-331.
28. Moore, M., Choo, Y. & Klug, A. (2001) Proc. Natl. Acad. Sci. USA 98, 1432-1436.
29. Moore, M., Klug, A. & Choo, Y. (2001) Proc. Natl. Acad. Sci. USA 98, 1437-1441.
30. Kalderon, D., Roberts, B. L., Richardson, W. D. & Smith, A. E. (1984) Cell 39, 499-509.
31. Margolin J. F., Friedman J. R., Meyer W. K., Vissing, H., Thiesen, H. J. & Rauscher, F. J., III (1994) Proc. Natl. Acad. Sci. USA 91, 4509-4513.
32. Evan, G. I., Lewis, G. K., Ramsay, G. & Bishop, J. M. (1985) Mol. Cell. Biol. 5, 3610-3616.
33. Dingwall, C., Ernberg, I., Gait, M. J., Green, S. M., Heaphy, S., Karn, J., Lowe, A. D., Singh, M. & Skinner, M. A. (1990) EMBO J. 9, 4145-4153.
34. West, M. J., Lowe, A. D. & Karn, J. (2001) J. Virol. 75, 8524-8537.
35. Dingwall, C., Ernberg, I., Gait, M. J., Green, S. M., Heaphy, S., Karn, J., Lowe, A. D., Singh, M., Skinner, M. A. & Valerio, R. (1989) Proc. Natl. Acad. Sci. USA 86, 6925-6929.
36. Soda, Y., Shimizu, N., Jinno, A., Liu, H. Y., Kanbe, K., Kitamura, T. & Hoshino, H. (1999) Biochem. Biophys. Res. Commun. 258, 313-321.
37. McKnight, A., Weiss, R. A., Shotton, C., Takeuchi, Y., Hoshino, H. & Clapham, P. R. (1995) J. Virol. 69, 3167-3170.
38. Jones, K. A. & Peterlin, B. M. (1994) Annu. Rev. Biochem. 63, 717-743.
39. Perkins, N. D., Edwards, N. L., Duckett, C. S., Agranoff, A. B., Schmid, R. M. & Nabel, G. J. (1993) EMBO J. 12, 3551-3558.
40. Verdin, E. (1991) J. Virol. 65, 6790-6799.
41. Verdin, E., Paras, P. J. & Van Lint, C. (1993) EMBO J. 12, 3249-3259.
42. Kim, J. Y. H., Gonzales-Scarano, F., Zeichner, S. L. & Alwine, J. C. (1993) J. Virol. 67, 1658-1662.
43. Sheridan, P. L. Sheline, C. T., Cannon, K., Voz, M. L., Pazin, M. J., Kadonaga, J. T. & Jones, K. A. (1995) Genes Dev. 9, 2090-2104.
44. Steger, D. J. & Workman, J. L. (1997) EMBO J. 16, 2463-2472.
45. Van Lint, C., Emiliani, S., Ott, M. & Verdin, E. (1996) EMBO J. 15, 1112-1120.
46. Ryan, R. F., Schultz, D. C., Ayyanathan, K., Singh, P. B., Friedman, J. R., Fredericks, W. J. & Rauscher, F. J., III (1999) Mol. Cell. Biol. 19, 4366-4378.
47. Lois, C., Hong, E. J., Pease, S., Brown, E. J. & Baltimore, D. (2002) Science 295, 868-872.