Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

Nature Biotechnology

Volumn 26, Issue 7, 2008, Pages 808-816

  Perez, Elena E ^a,b   Wang, Jianbin ^c   Miller, Jeffrey C ^c   Jouvenot, Yann ^c,d   Kim, Kenneth A ^c   Liu, Olga ^a   Wang, Nathaniel ^c   Lee, Gary ^c   Bartsevich, Victor V ^c   Lee, Ya Li ^c   Guschin, Dmitry Y ^c   Rupniewski, Igor ^c   Waite, Adam J ^c   Carpenito, Carmine ^a   Carroll, Richard G ^a   Orange, Jordan S ^b   Urnov, Fyodor D ^c   Rebar, Edward J ^c   Ando, Dale ^c   Gregory, Philip D ^c   Riley, James L ^a   Holmes, Michael C ^c   June, Carl H ^a   more..

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c SANGAMO BIOSCIENCES INC   (United States)

^d BAYER CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ZINC; ZINC SULFIDE;

RECEPTOR (IR); TRANSIENT EXPRESSIONS; ZINC FINGER NUCLEASES;

HEALTH;

CHEMOKINE RECEPTOR CCR5; PROTEIN P53; ZINC FINGER PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; CD4+ T LYMPHOCYTE; CELL PROTECTION; CELL SPECIFICITY; CELL SURVIVAL; CONTROLLED STUDY; FEMALE; GENE DELETION; GENE DISRUPTION; GENE EXPRESSION; GENE INSERTION; GENOTYPE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; INFECTION RESISTANCE; MALE; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; VIREMIA; VIRUS LOAD; VIRUS RESISTANCE;

ADOPTIVE TRANSFER; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CHROMOSOME MAPPING; DEOXYRIBONUCLEASES; GENETIC ENGINEERING; HIV INFECTIONS; HUMANS; IMMUNITY, NATURAL; MICE; TREATMENT OUTCOME; ZINC FINGERS;

HUMAN IMMUNODEFICIENCY VIRUS 1; MUS;

EID: 46949095221     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt1410     Document Type: Article

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