-
1
-
-
0034234540
-
Increased hepatocyte turnover and inhibition of woodchuck hepatitis b virus replication by adefovir in vitro do not lead to reduction of the closed circular dna
-
Dandri, M, Burda, MR, Will, H and Petersen, J (2000). Increased hepatocyte turnover and inhibition of woodchuck hepatitis B virus replication by adefovir in vitro do not lead to reduction of the closed circular DNA. Hepatology 32: 139-146.
-
(2000)
Hepatology
, vol.32
, pp. 139-146
-
-
Dandri, M.1
Burda, M.R.2
Will, H.3
Petersen, J.4
-
2
-
-
0030776176
-
Lack of effect of antiviral therapy in nondividing hepatocyte cultures on the closed circular dna of woodchuck hepatitis virus
-
Moraleda, G, Saputelli, J, Aldrich, CE, Averett, D, Condreay, L and Mason, WS (1997). Lack of effect of antiviral therapy in nondividing hepatocyte cultures on the closed circular DNA of woodchuck hepatitis virus. J Virol 71: 9392-9399.
-
(1997)
J Virol
, vol.71
, pp. 9392-9399
-
-
Moraleda, G.1
Saputelli, J.2
Aldrich, C.E.3
Averett, D.4
Condreay, L.5
Mason, W.S.6
-
3
-
-
0033029334
-
Biphasic clearance kinetics of hepatitis b virus from patients during adefovir dipivoxil therapy
-
Tsiang, M, Rooney, JF, Toole, JJ and Gibbs, CS (1999). Biphasic clearance kinetics of hepatitis B virus from patients during adefovir dipivoxil therapy. Hepatology 29: 1863-1869.
-
(1999)
Hepatology
, vol.29
, pp. 1863-1869
-
-
Tsiang, M.1
Rooney, J.F.2
Toole, J.J.3
Gibbs, C.S.4
-
4
-
-
2942532722
-
Persistence of cccdna during the natural history of chronic hepatitis b and decline during adefovir dipivoxil therapy
-
Werle-Lapostolle, B, Bowden, S, Locarnini, S, Wursthorn, K, Petersen, J, Lau, G, et al. (2004). Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy. Gastroenterology 126: 1750-1758.
-
(2004)
Gastroenterology
, vol.126
, pp. 1750-1758
-
-
Werle-Lapostolle, B.1
Bowden, S.2
Locarnini, S.3
Wursthorn, K.4
Petersen, J.5
Lau, G.6
-
5
-
-
29744468790
-
Cccdna persistence during natural evolution of chronic vhb infection
-
Caruntu, FA and Molagic, V (2005). CccDNA persistence during natural evolution of chronic VHB infection. Rom J Gastroenterol 14: 373-377.
-
(2005)
Rom J Gastroenterol
, vol.14
, pp. 373-377
-
-
Caruntu, F.A.1
Molagic, V.2
-
6
-
-
20444505037
-
Intrahepatic hepatitis b virus covalently closed circular dna can be a predictor of sustained response to therapy
-
Sung, JJ, Wong, ML, Bowden, S, Liew, CT, Hui, AY, Wong, VW et al. (2005). Intrahepatic hepatitis B virus covalently closed circular DNA can be a predictor of sustained response to therapy. Gastroenterology 128: 1890-1897.
-
(2005)
Gastroenterology
, vol.128
, pp. 1890-1897
-
-
Sung, J.J.1
Wong, M.L.2
Bowden, S.3
Liew, C.T.4
Hui, A.Y.5
Wong, V.W.6
-
7
-
-
84880799657
-
Predictors of hepatitis b cure using gene therapy to deliver dna cleavage enzymes: A mathematical modeling approach
-
Schiffer, JT, Swan, DA, Stone, D and Jerome, KR (2013). Predictors of hepatitis B cure using gene therapy to deliver DNA cleavage enzymes: a mathematical modeling approach. PLoS Comput Biol 9: e1003131.
-
(2013)
PLoS Comput Biol
, vol.9
-
-
Schiffer, J.T.1
Swan, D.A.2
Stone, D.3
Jerome, K.R.4
-
8
-
-
77952011493
-
Zinc-finger nucleases as a novel therapeutic strategy for targeting hepatitis b virus dnas
-
Cradick, TJ, Keck, K, Bradshaw, S, Jamieson, AC and McCaffrey, AP (2010). Zinc-finger nucleases as a novel therapeutic strategy for targeting hepatitis B virus DNAs. Mol Ther 18: 947-954.
-
(2010)
Mol Ther
, vol.18
, pp. 947-954
-
-
Cradick, T.J.1
Keck, K.2
Bradshaw, S.3
Jamieson, A.C.4
McCaffrey, A.P.5
-
9
-
-
84885023096
-
Inactivation of hepatitis b virus replication in cultured cells and in vivo with engineered transcription activator-like effector nucleases
-
Bloom, K, Ely, A, Mussolino, C, Cathomen, T and Arbuthnot, P (2013). Inactivation of hepatitis B virus replication in cultured cells and in vivo with engineered transcription activator-like effector nucleases. Mol Ther 21: 1889-1897.
-
(2013)
Mol Ther
, vol.21
, pp. 1889-1897
-
-
Bloom, K.1
Ely, A.2
Mussolino, C.3
Cathomen, T.4
Arbuthnot, P.5
-
10
-
-
84895908706
-
An efficient antiviral strategy for targeting hepatitis b virus genome using transcription activator-like effector nucleases
-
Chen, J, Zhang, W, Lin, J, Wang, F, Wu, M, Chen, C et al. (2014). An efficient antiviral strategy for targeting hepatitis B virus genome using transcription activator-like effector nucleases. Mol Ther 22: 303-311.
-
(2014)
Mol Ther
, vol.22
, pp. 303-311
-
-
Chen, J.1
Zhang, W.2
Lin, J.3
Wang, F.4
Wu, M.5
Chen, C.6
-
11
-
-
84868342049
-
In vivo genome editing using a high-efficiency talen system
-
Bedell, VM, Wang, Y, Campbell, JM, Poshusta, TL, Starker, CG, Krug, RG 2nd et al. (2012). In vivo genome editing using a high-efficiency TALEN system. Nature 491: 114-118.
-
(2012)
Nature
, vol.491
, pp. 114-118
-
-
Bedell, V.M.1
Wang, Y.2
Campbell, J.M.3
Poshusta, T.L.4
Starker, C.G.5
Krug II, R.G.6
-
12
-
-
84879264708
-
Zfn talen and crispr/cas-based methods for genome engineering
-
Gaj, T, Gersbach, CA and Barbas, CF 3rd (2013). ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering. Trends Biotechnol 31: 397-405.
-
(2013)
Trends Biotechnol
, vol.31
, pp. 397-405
-
-
Gaj, T.1
Gersbach, C.A.2
Barbas III, C.F.3
-
13
-
-
84882449996
-
Biological and biomedical applications of engineered nucleases
-
Pan, Y, Xiao, L, Li, AS, Zhang, X, Sirois, P, Zhang, J et al. (2013). Biological and biomedical applications of engineered nucleases. Mol Biotechnol 55: 54-62.
-
(2013)
Mol Biotechnol
, vol.55
, pp. 54-62
-
-
Pan, Y.1
Xiao, L.2
Li, A.S.3
Zhang, X.4
Sirois, P.5
Zhang, J.6
-
14
-
-
77957935381
-
Crispr/cas system and its role in phage-bacteria interactions
-
Deveau, H, Garneau, JE and Moineau, S (2010). CRISPR/Cas system and its role in phage-bacteria interactions. Annu Rev Microbiol 64: 475-493.
-
(2010)
Annu Rev Microbiol
, vol.64
, pp. 475-493
-
-
Deveau, H.1
Garneau, J.E.2
Moineau, S.3
-
15
-
-
80755187812
-
Crispr-cas systems in bacteria and archaea: Versatile small rnas for adaptive defense and regulation
-
Bhaya, D, Davison, M and Barrangou, R (2011). CRISPR-Cas systems in bacteria and archaea: versatile small RNAs for adaptive defense and regulation. Annu Rev Genet 45: 273-297.
-
(2011)
Annu Rev Genet
, vol.45
, pp. 273-297
-
-
Bhaya, D.1
Davison, M.2
Barrangou, R.3
-
16
-
-
79956157571
-
Evolution and classification of the crispr-cas systems
-
Makarova, KS, Haft, DH, Barrangou, R, Brouns, SJ, Charpentier, E, Horvath, P et al. (2011). Evolution and classification of the CRISPR-Cas systems. Nat Rev Microbiol 9: 467-477.
-
(2011)
Nat Rev Microbiol
, vol.9
, pp. 467-477
-
-
Makarova, K.S.1
Haft, D.H.2
Barrangou, R.3
Brouns, S.J.4
Charpentier, E.5
Horvath, P.6
-
17
-
-
84857097177
-
Rna-guided genetic silencing systems in bacteria and archaea
-
Wiedenheft, B, Sternberg, SH and Doudna, JA (2012). RNA-guided genetic silencing systems in bacteria and archaea. Nature 482: 331-338.
-
(2012)
Nature
, vol.482
, pp. 331-338
-
-
Wiedenheft, B.1
Sternberg, S.H.2
Doudna, J.A.3
-
18
-
-
84865070369
-
A programmable dual-rna-guided dna endonuclease in adaptive bacterial immunity
-
Jinek, M, Chylinski, K, Fonfara, I, Hauer, M, Doudna, JA and Charpentier, E (2012). A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337: 816-821.
-
(2012)
Science
, vol.337
, pp. 816-821
-
-
Jinek, M.1
Chylinski, K.2
Fonfara, I.3
Hauer, M.4
Doudna, J.A.5
Charpentier, E.6
-
19
-
-
84873734105
-
Rna-guided human genome engineering via cas9
-
Mali, P, Yang, L, Esvelt, KM, Aach, J, Guell, M, DiCarlo, JE et al. (2013). RNA-guided human genome engineering via Cas9. Science 339: 823-826.
-
(2013)
Science
, vol.339
, pp. 823-826
-
-
Mali, P.1
Yang, L.2
Esvelt, K.M.3
Aach, J.4
Guell, M.5
DiCarlo, J.E.6
-
20
-
-
84873729095
-
Multiplex genome engineering using crispr/cas systems
-
Cong, L, Ran, FA, Cox, D, Lin, S, Barretto, R, Habib, N et al. (2013). Multiplex genome engineering using CRISPR/Cas systems. Science 339: 819-823.
-
(2013)
Science
, vol.339
, pp. 819-823
-
-
Cong, L.1
Ran, F.A.2
Cox, D.3
Lin, S.4
Barretto, R.5
Habib, N.6
-
21
-
-
84874624936
-
Targeted genome engineering in human cells with the cas9 rna-guided endonuclease
-
Cho, SW, Kim, S, Kim, JM and Kim, JS (2013). Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease. Nat Biotechnol 31: 230-232.
-
(2013)
Nat Biotechnol
, vol.31
, pp. 230-232
-
-
Cho, S.W.1
Kim, S.2
Kim, J.M.3
Kim, J.S.4
-
22
-
-
84876567971
-
Rna-programmed genome editing in human cells
-
Jinek, M, East, A, Cheng, A, Lin, S, Ma, E and Doudna, J (2013). RNA-programmed genome editing in human cells. Elife 2: e00471.
-
(2013)
Elife
, vol.2
-
-
Jinek, M.1
East, A.2
Cheng, A.3
Lin, S.4
Ma, E.5
Doudna, J.6
-
23
-
-
84881475586
-
Heritable genome editing in c. Elegans via a crispr-cas9 system
-
Friedland, AE, Tzur, YB, Esvelt, KM, Colaiácovo, MP, Church, GM and Calarco, JA (2013). Heritable genome editing in C. elegans via a CRISPR-Cas9 system. Nat Methods 10: 741-743.
-
(2013)
Nat Methods
, vol.10
, pp. 741-743
-
-
Friedland, A.E.1
Tzur, Y.B.2
Esvelt, K.M.3
Colaiácovo, M.P.4
Church, G.M.5
Calarco, J.A.6
-
24
-
-
84874617789
-
Efficient genome editing in zebrafish using a crispr-cas system
-
Hwang, WY, Fu, Y, Reyon, D, Maeder, ML, Tsai, SQ, Sander, JD et al. (2013). Efficient genome editing in zebrafish using a CRISPR-Cas system. Nat Biotechnol 31: 227-229.
-
(2013)
Nat Biotechnol
, vol.31
, pp. 227-229
-
-
Hwang, W.Y.1
Fu, Y.2
Reyon, D.3
Maeder, M.L.4
Tsai, S.Q.5
Sander, J.D.6
-
25
-
-
84884943528
-
Targeted heritable mutation and gene conversion by cas9-crispr in caenorhabditis elegans
-
Katic, I and Großhans, H (2013). Targeted heritable mutation and gene conversion by Cas9-CRISPR in Caenorhabditis elegans. Genetics 195: 1173-1176.
-
(2013)
Genetics
, vol.195
, pp. 1173-1176
-
-
Katic, I.1
Großhans, H.2
-
26
-
-
84877707375
-
Onestep generation of mice carrying mutations in multiple genes by crispr/cas-mediated genome engineering
-
Wang, H, Yang, H, Shivalila, CS, Dawlaty, MM, Cheng, AW, Zhang, F et al. (2013). Onestep generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell 153: 910-918.
-
(2013)
Cell
, vol.153
, pp. 910-918
-
-
Wang, H.1
Yang, H.2
Shivalila, C.S.3
Dawlaty, M.M.4
Cheng, A.W.5
Zhang, F.6
-
27
-
-
78149319907
-
Generation of covalently closed circular dna of hepatitis b viruses via intracellular recycling is regulated in a virus specific manner
-
Köck, J, Rösler, C, Zhang, JJ, Blum, HE, Nassal, M and Thoma, C (2010). Generation of covalently closed circular DNA of hepatitis B viruses via intracellular recycling is regulated in a virus specific manner. PLoS Pathog 6: e1001082.
-
(2010)
PLoS Pathog
, vol.6
-
-
Köck, J.1
Rösler, C.2
Zhang, J.J.3
Blum, H.E.4
Nassal, M.5
Thoma, C.6
-
28
-
-
84983721048
-
An immunocompetent mouse model for the tolerance of human chronic hepatitis b virus infection
-
Huang, LR, Wu, HL, Chen, PJ and Chen, DS (2006). An immunocompetent mouse model for the tolerance of human chronic hepatitis B virus infection. Proc Natl Acad Sci USA 103: 17862-17867.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 17862-17867
-
-
Huang, L.R.1
Wu, H.L.2
Chen, P.J.3
Chen, D.S.4
-
29
-
-
84879315928
-
Blocking the natural killer cell inhibitory receptor nkg2a increases activity of human natural killer cells and clears hepatitis b virus infection in mice
-
Li, F, Wei, H, Wei, H, Gao, Y, Xu, L, Yin, W et al. (2013). Blocking the natural killer cell inhibitory receptor NKG2A increases activity of human natural killer cells and clears hepatitis B virus infection in mice. Gastroenterology 144: 392-401.
-
(2013)
Gastroenterology
, vol.144
, pp. 392-401
-
-
Li, F.1
Wei, H.2
Wei, H.3
Gao, Y.4
Xu, L.5
Yin, W.6
-
30
-
-
84891710947
-
Analysis of off-target effects of crispr/cas-derived rna-guided endonucleases and nickases
-
Cho, SW, Kim, S, Kim, Y, Kweon, J, Kim, HS, Bae, S et al. (2014). Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases. Genome Res 24: 132-141.
-
(2014)
Genome Res
, vol.24
, pp. 132-141
-
-
Cho, S.W.1
Kim, S.2
Kim, Y.3
Kweon, J.4
Kim, H.S.5
Bae, S.6
-
31
-
-
84880570576
-
Highfrequency off-target mutagenesis induced by crispr-cas nucleases in human cells
-
Fu, Y, Foden, JA, Khayter, C, Maeder, ML, Reyon, D, Joung, JK et al. (2013). Highfrequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells. Nat Biotechnol 31: 822-826.
-
(2013)
Nat Biotechnol
, vol.31
, pp. 822-826
-
-
Fu, Y.1
Foden, J.A.2
Khayter, C.3
Maeder, M.L.4
Reyon, D.5
Joung, J.K.6
-
32
-
-
84884288934
-
Double nicking by rna-guided crispr cas9 for enhanced genome editing specificity
-
Ran, FA, Hsu, PD, Lin, CY, Gootenberg, JS, Konermann, S, Trevino, AE et al. (2013). Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity. Cell 154: 1380-1389.
-
(2013)
Cell
, vol.154
, pp. 1380-1389
-
-
Ran, F.A.1
Hsu, P.D.2
Lin, C.Y.3
Gootenberg, J.S.4
Konermann, S.5
Trevino, A.E.6
-
33
-
-
84884160273
-
Cas9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering
-
Mali, P, Aach, J, Stranges, PB, Esvelt, KM, Moosburner, M, Kosuri, S et al. (2013). CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nat Biotechnol 31: 833-838.
-
(2013)
Nat Biotechnol
, vol.31
, pp. 833-838
-
-
Mali, P.1
Aach, J.2
Stranges, P.B.3
Esvelt, K.M.4
Moosburner, M.5
Kosuri, S.6
-
34
-
-
68049132846
-
Control of cccdna function in hepatitis b virus infection
-
Levrero, M, Pollicino, T, Petersen, J, Belloni, L, Raimondo, G and Dandri, M (2009). Control of cccDNA function in hepatitis B virus infection. J Hepatol 51: 581-592.
-
(2009)
J Hepatol
, vol.51
, pp. 581-592
-
-
Levrero, M.1
Pollicino, T.2
Petersen, J.3
Belloni, L.4
Raimondo, G.5
Dandri, M.6
-
35
-
-
84901648428
-
High-efficiency targeted editing of large viral genomes by rna-guided nucleases
-
Bi, Y, Sun, L, Gao, D, Ding, C, Li, Z, Li, Y et al. (2014). High-efficiency targeted editing of large viral genomes by RNA-guided nucleases. PLoS Pathog 10: e1004090.
-
(2014)
PLoS Pathog
, vol.10
-
-
Bi, Y.1
Sun, L.2
Gao, D.3
Ding, C.4
Li, Z.5
Li, Y.6
-
36
-
-
84883305437
-
Harnessing the crispr/cas9 system to disrupt latent hiv-1 provirus
-
Ebina, H, Misawa, N, Kanemura, Y and Koyanagi, Y (2013). Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus. Sci Rep 3: 2510.
-
(2013)
Sci Rep
, vol.3
, pp. 2510
-
-
Ebina, H.1
Misawa, N.2
Kanemura, Y.3
Koyanagi, Y.4
-
37
-
-
0014202537
-
Selective extraction of polyoma dna from infected mouse cell cultures
-
Hirt, B (1967). Selective extraction of polyoma DNA from infected mouse cell cultures. J Mol Biol 26: 365-369.
-
(1967)
J Mol Biol
, vol.26
, pp. 365-369
-
-
Hirt, B.1
-
38
-
-
84876352590
-
Using defined finger-finger interfaces as units of assembly for constructing zinc-finger nucleases
-
Zhu, C, Gupta, A, Hall, VL, Rayla, AL, Christensen, RG, Dake, B et al. (2013). Using defined finger-finger interfaces as units of assembly for constructing zinc-finger nucleases. Nucleic Acids Res 41: 2455-2465.
-
(2013)
Nucleic Acids Res
, vol.41
, pp. 2455-2465
-
-
Zhu, C.1
Gupta, A.2
Hall, V.L.3
Rayla, A.L.4
Christensen, R.G.5
Dake, B.6
-
39
-
-
77957754251
-
A rapid and general assay for monitoring endogenous gene modification
-
Guschin, DY, Waite, AJ, Katibah, GE, Miller, JC, Holmes, MC and Rebar, EJ (2010). A rapid and general assay for monitoring endogenous gene modification. Methods Mol Biol 649: 247-256.
-
(2010)
Methods Mol Biol
, vol.649
, pp. 247-256
-
-
Guschin, D.Y.1
Waite, A.J.2
Katibah, G.E.3
Miller, J.C.4
Holmes, M.C.5
Rebar, E.J.6
-
40
-
-
0021111829
-
The complete nucleotide sequences of the cloned hepatitis b virus dna; subtype adr and adw
-
Ono, Y, Onda, H, Sasada, R, Igarashi, K, Sugino, Y and Nishioka, K (1983). The complete nucleotide sequences of the cloned hepatitis B virus DNA; subtype adr and adw. Nucleic Acids Res 11: 1747-1757.
-
(1983)
Nucleic Acids Res
, vol.11
, pp. 1747-1757
-
-
Ono, Y.1
Onda, H.2
Sasada, R.3
Igarashi, K.4
Sugino, Y.5
Nishioka, K.6
|