Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection

Nature Methods

Volumn 8, Issue 9, 2011, Pages 765-772

  Pattanayak, Vikram ^a   Ramirez, Cherie L ^b,c   Joung, J Keith ^b,c   Liu, David R ^a  

^a HARVARD UNIVERSITY   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5; NUCLEASE; UNCLASSIFIED DRUG; VASCULOTROPIN A; ZINC FINGER NUCLEASE; ZINC FINGER NUCLEASE CCR5 224; ZINC FINGER NUCLEASE VF2468;

ARTICLE; DNA CLEAVAGE; DNA SEQUENCE; ENZYME SPECIFICITY; GENE LOCUS; GENE MUTATION; GENETIC ENGINEERING; HUMAN; HUMAN CELL; IN VITRO SELECTION; PRIORITY JOURNAL; PROTEIN DNA BINDING;

BASE SEQUENCE; BINDING SITES; CELLS, CULTURED; DNA; DNA-BINDING PROTEINS; ENDODEOXYRIBONUCLEASES; HUMANS; K562 CELLS; SUBSTRATE SPECIFICITY; ZINC FINGERS;

EID: 80052293623     PISSN: 15487091     EISSN: 15491676     Source Type: Journal    
DOI: 10.1038/nmeth.1670     Document Type: Article

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