High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

Cell

Volumn 163, Issue 6, 2015, Pages 1515-1526

  Hart, Traver ^a   Chandrashekhar, Megha ^a   Aregger, Michael ^a   Steinhart, Zachary ^b   Brown, Kevin R ^a   MacLeod, Graham ^b   Mis, Monika ^b   Zimmermann, Michal ^c   Fradet Turcotte, Amelie ^c   Sun, Song ^a,b,e   Mero, Patricia ^a   Dirks, Peter ^a,f   Sidhu, Sachdev ^a   Roth, Frederick P ^a,b,c,g,h   Rissland, Olivia S ^a,d   Durocher, Daniel ^a,c   Angers, Stephane ^a,b   Moffat, Jason ^a,g,i  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c MOUNT SINAI HOSPITAL   (Canada)

^d HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^e UPPSALA UNIVERSITY   (Sweden)

^f HOSPITAL FOR SICK CHILDREN   (Canada)

^g CANADIAN INSTITUTE FOR ADVANCED RESEARCH   (Canada)

^h DANA FARBER CANCER INSTITUTE   (United States)

ⁱ UNIVERSITÉ LAVAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

K RAS PROTEIN; PROTEIN TYROSINE KINASE;

ARTICLE; BAYES THEOREM; BINDING SITE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONTROLLED STUDY; CRISPR CAS SYSTEM; EXON; FEMALE; FITNESS GENE; GENE; GENE LIBRARY; GENE ONTOLOGY; GENOTYPE; HCT116 CELL LINE; HUMAN; HUMAN CELL; MALIGNANT NEOPLASTIC DISEASE; ONCOGENE; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN INTERACTION; ESSENTIAL GENE; GENE INACTIVATION; MUTATION; TUMOR CELL LINE;

BAYES THEOREM; CELL LINE, TUMOR; CRISPR-CAS SYSTEMS; GENE KNOCKOUT TECHNIQUES; GENE LIBRARY; GENES, ESSENTIAL; HUMANS; MUTATION;

EID: 84949233942     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2015.11.015     Document Type: Article

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