Creating a monomeric endonuclease TALE-I-SceI with high specificity and low genotoxicity in human cells

Nucleic Acids Research

Volumn 43, Issue 2, 2015, Pages 1112-1122

  Lin, Jianfei ^a,b   Chen, He ^a   Luo, Ling ^c   Lai, Yongrong ^c   Xie, Wei ^d   Kee, Kehkooi ^b  

^a PEKING UNIVERSITY   (China)

^b TSINGHUA UNIVERSITY   (China)

^c GUANGXI MEDICAL UNIVERSITY   (China)

^d Tsinghua University   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBONUCLEASE; DNA BINDING PROTEIN; HEMOGLOBIN BETA CHAIN; HYBRID PROTEIN;

CELL CULTURE; CELL LINE; CHEMISTRY; CRISPR CAS SYSTEM; GENETICS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN GENOME; METABOLISM; PROTEIN ENGINEERING; PROTEIN TERTIARY STRUCTURE; RECOMBINATION REPAIR; TARGETED GENE REPAIR;

BETA-GLOBINS; CELL LINE; CELLS, CULTURED; CRISPR-CAS SYSTEMS; DNA-BINDING PROTEINS; ENDODEOXYRIBONUCLEASES; GENOME, HUMAN; HEMATOPOIETIC STEM CELLS; HUMANS; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; RECOMBINATIONAL DNA REPAIR; TARGETED GENE REPAIR;

EID: 84941041246     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gku1339     Document Type: Article

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