Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9

Nature Biotechnology

Volumn 34, Issue 2, 2016, Pages 192-198

  Korkmaz, Gozde ^a   Lopes, Rui ^a   Ugalde, Alejandro P ^a   Nevedomskaya, Ekaterina ^a   Han, Ruiqi ^a   Myacheva, Ksenia ^a   Zwart, Wilbert ^a   Elkon, Ran ^a   Agami, Reuven ^a,b  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES; TRANSCRIPTION;

FUNCTIONAL DOMAINS; GENETIC SCREENS; HUMAN GENOMES; REGULATORY ELEMENTS; REPORTER ASSAY; SYSTEMATIC IDENTIFICATION; TRANSCRIPTION FACTOR BINDING SITES;

GENES;

CRISPR ASSOCIATED PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; ESTROGEN RECEPTOR ALPHA; PROTEIN P53;

ARTICLE; BINDING SITE; BREAST TUMOR; CARCINOGENESIS; CELL PROLIFERATION; COMPARATIVE STUDY; DOWN REGULATION; ENHANCER REGION; G1 PHASE CELL CYCLE CHECKPOINT; GENE CONTROL; HUMAN; HUMAN GENOME; MCF 7 CELL LINE; NEXT GENERATION SEQUENCING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION SITE; ANIMAL; CELL LINE; CRISPR CAS SYSTEM; GENE INACTIVATION; GENETIC ENGINEERING; GENETICS; GENOMICS; MOUSE; PROCEDURES;

ANIMALS; CELL LINE; CRISPR-CAS SYSTEMS; ENHANCER ELEMENTS, GENETIC; GENE KNOCKOUT TECHNIQUES; GENETIC ENGINEERING; GENOME, HUMAN; GENOMICS; HUMANS; MCF-7 CELLS; MICE;

EID: 84957590341     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.3450     Document Type: Article

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