Engineering human tumour-associated chromosomal translocations with the RNA-guided CRISPR-Cas9 system

Nature Communications

Volumn 5, Issue , 2014, Pages

  Torres, R ^a   Martin, M C ^b   Garcia, A ^a   Cigudosa, Juan C ^b   Ramirez, J C ^a   Rodriguez Perales, S ^b  

^a CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^b Centro Nacional de Investigaciones Oncológicas   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

GUIDE RNA; CALMODULIN BINDING PROTEIN; EWSR1 PROTEIN, HUMAN; FLI1 PROTEIN, HUMAN; MESSENGER RNA; ONCOPROTEIN; RNA BINDING PROTEIN; RUNX1 PROTEIN, HUMAN; RUNX1T1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FLI 1; TRANSCRIPTION FACTOR RUNX1;

CANCER; CELL ORGANELLE; CHROMOSOME; MOLECULAR ANALYSIS; RNA; TUMOR;

ACCURACY; ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CELL ENGINEERING; CLINICAL FEATURE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT CAS9 SYSTEM; CODON USAGE; CONTROLLED STUDY; CRISPR CAS SYSTEM; DOUBLE STRAND BREAK; EWING SARCOMA; EXON; FLUORESCENCE IN SITU HYBRIDIZATION; FUSION GENE; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC ENGINEERING; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERPHASE; INTRON; MALIGNANT NEOPLASTIC DISEASE; METAPHASE; NUCLEIC ACID STRUCTURE, METABOLISM AND FUNCTION; PRIMARY CELL; PROTEIN BLOOD LEVEL; RECIPROCAL CHROMOSOME TRANSLOCATION; RELIABILITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; WESTERN BLOTTING; ACUTE MYELOBLASTIC LEUKEMIA; DOUBLE STRANDED DNA BREAK; GENE FUSION; GENE TRANSLOCATION; GENETICS; METABOLISM;

ARTIFICIAL GENE FUSION; CALMODULIN-BINDING PROTEINS; CORE BINDING FACTOR ALPHA 2 SUBUNIT; CRISPR-CAS SYSTEMS; DNA BREAKS, DOUBLE-STRANDED; HUMANS; IN VITRO TECHNIQUES; LEUKEMIA, MYELOID, ACUTE; ONCOGENE PROTEINS, FUSION; PROTO-ONCOGENE PROTEIN C-FLI-1; PROTO-ONCOGENE PROTEINS; RNA, GUIDE; RNA, MESSENGER; RNA-BINDING PROTEINS; SARCOMA, EWING; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC;

EID: 84901951241     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms4964     Document Type: Article

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