Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification

Nature Biotechnology

Volumn 32, Issue 6, 2014, Pages 577-582

  Guilinger, John P ^a,b   Thompson, David B ^a,b   Liu, David R ^a,b  

^a HARVARD UNIVERSITY   (United States)

^b HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; MONOMERS;

DNA CLEAVAGE; DNA MODIFICATION; DNA STRANDS; DOUBLE STRANDED DNA; GENOME MODIFICATION; HUMAN CELLS; HUMAN GENOMES; TARGET SITES;

GENES;

CRISPR ASSOCIATED PROTEIN; MONOMER;

ARTICLE; CONTROLLED STUDY; DNA CLEAVAGE; DNA MODIFICATION; DNA STRAND; ENZYME INACTIVATION; ENZYME SPECIFICITY; GENE FUSION; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; RNA EDITING;

CASPASE 9; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; DIMERIZATION; GENOME; HUMANS; RECOMBINANT FUSION PROTEINS; RNA; RNA EDITING;

EID: 84902210542     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.2909     Document Type: Article

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