Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

Nature

Volumn 533, Issue , 2016, Pages 420-424

  Komor, Alexis C ^a,b   Kim, Yongjoo B ^a,b   Packer, Michael S ^a,b   Zuris, John A ^a,b   Liu, David R ^a,b  

^a HARVARD UNIVERSITY   (United States)

^b HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 1; APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3G; APOLIPOPROTEIN E; APOLIPOPROTEIN E2; APOLIPOPROTEIN E3; CELL DNA; CRISPR ASSOCIATED PROTEIN; CYTIDINE; CYTIDINE DEAMINASE; DNA BASE; DOUBLE STRANDED DNA; GENOMIC DNA; GUIDE RNA; NUCLEOTIDE; URACIL; URACIL DNA GLYCOSIDASE; URIDINE; APOBEC1 PROTEIN, HUMAN; APOBEC1 PROTEIN, MOUSE; APOLIPOPROTEIN E4; DEOXYRIBONUCLEASE I; DNA;

CELLS AND CELL COMPONENTS; DNA; ENZYME; ENZYME ACTIVITY; GENE; GENOME; HUMAN ACTIVITY; MUTATION; RODENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CLINICAL ASSESSMENT; CLINICAL EVALUATION; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; DEAMINATION; DNA STRAND; DNA STRAND BREAKAGE; GENE EXPRESSION; GENE TARGETING; GENETIC ENGINEERING; GENOME ANALYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; OUTCOME ASSESSMENT; POINT MUTATION; PRIORITY JOURNAL; RAT; RNA EDITING; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CRISPR CAS SYSTEM; DNA CLEAVAGE; DNA REPAIR; DNA TEMPLATE; GENETICS; GENOME; INDEL MUTATION; METABOLISM; MOUSE; NUCLEOTIDE SEQUENCE; PROCEDURES; TUMOR SUPPRESSOR GENE;

MURINAE;

ANIMALS; APOBEC-1 DEAMINASE; APOLIPOPROTEIN E4; BASE SEQUENCE; CELL LINE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; CRISPR-ASSOCIATED PROTEINS; CRISPR-CAS SYSTEMS; CYTIDINE; CYTIDINE DEAMINASE; DEOXYRIBONUCLEASE I; DNA; DNA CLEAVAGE; DNA REPAIR; GENES, P53; GENETIC ENGINEERING; GENOME; HUMANS; INDEL MUTATION; MICE; POINT MUTATION; RNA, GUIDE; TEMPLATES, GENETIC; URACIL-DNA GLYCOSIDASE; URIDINE;

EID: 84971006562     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature17946     Document Type: Article

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