RNA-guided human genome engineering via Cas9

Science

Volumn 339, Issue 6121, 2013, Pages 823-826

  Mali, Prashant ^a   Yang, Luhan ^a   Esvelt, Kevin M ^b   Aach, John ^a   Guell, Marc ^a   DiCarlo, James E ^c   Norville, Julie E ^a   Church, George M ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD UNIVERSITY   (United States)

^c Boston University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAS9 PROTEIN; DNA METHYLTRANSFERASE 3A; DOUBLE STRANDED DNA; GUIDE RNA; RNA; UNCLASSIFIED DRUG; ZINC FINGER NUCLEASE;

ADAPTATION; EVOLUTIONARY BIOLOGY; GENETIC ENGINEERING; GENOME; HOMINID; IMMUNE SYSTEM; PROKARYOTE; RNA;

ADAPTIVE IMMUNITY; ARTICLE; CELL STRAIN K 562; CHROMATIN STRUCTURE; CHROMOSOME 19; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT SYSTEM; GENE LOCUS; GENE TARGETING; GENETIC ENGINEERING; GENOMIC FRAGMENT; HUMAN; HUMAN CELL; HUMAN GENOME; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; STOP CODON;

BACTERIA (MICROORGANISMS);

EID: 84873734105     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1232033     Document Type: Article

References (28)

1. B. Wiedenheft, S. H. Sternberg, J. A. Doudna, Nature 482, 331 (2012).
2. D. Bhaya, M. Davison, R. Barrangou, Annu. Rev. Genet. 45, 273 (2011).
3. M. P. Terns, R. M. Terns, Curr. Opin. Microbiol. 14, 321 (2011).
4. M. Jinek et al., Science 337, 816 (2012).
5. G. Gasiunas, R. Barrangou, P. Horvath, V. Siksnys, Proc. Natl. Acad. Sci. U.S.A. 109, E2579 (2012).
6. R. Sapranauskas et al., Nucleic Acids Res. 39, 9275 (2011).
7. T. R. Brummelkamp, R. Bernards, R. Agami, Science 296, 550 (2002).
8. M. Miyagishi, K. Taira, Nat. Biotechnol. 20, 497 (2002).
9. E. Deltcheva et al., Nature 471, 602 (2011).
10. J. Zou, P. Mali, X. Huang, S. N. Dowey, L. Cheng, Blood 118, 4599 (2011).
11. N. E. Sanjana et al., Nat. Protoc. 7, 171 (2012).
12. J. H. Lee et al., PLoS Genet. 5, e1000718 (2009).
13. D. Hockemeyer et al., Nat. Biotechnol. 27, 851 (2009).
14. S. Kosuri et al., Nat. Biotechnol. 28, 1295 (2010).
15. V. Pattanayak, C. L. Ramirez, J. K. Joung, D. R. Liu, Nat. Methods 8, 765 (2011).
16. N. M. King, O. Cohen-Haguenauer, Mol. Ther. 16, 432 (2008).
17. Y. G. Kim, J. Cha, S. Chandrasegaran, Proc. Natl. Acad. Sci. U.S.A. 93, 1156 (1996).
18. E. J. Rebar, C. O. Pabo, Science 263, 671 (1994).
19. J. Boch et al., Science 326, 1509 (2009).
20. M. J. Moscou, A. J. Bogdanove, Science 326, 1501 (2009).
21. L. Cong et al., Science 339, 819 (2013).
22. A. S. Khalil, J. J. Collins, Nat. Rev. Genet. 11, 367 (2010).
23. P. E. Purnick, R. Weiss, Nat. Rev. Mol. Cell Biol. 10, 410 (2009).
24. J. Zou et al., Cell Stem Cell 5, 97 (2009).
25. N. Holt et al., Nat. Biotechnol. 28, 839 (2010).
26. F. D. Urnov et al., Nature 435, 646 (2005).
27. A. Lombardo et al., Nat. Biotechnol. 25, 1298 (2007).
28. H. Li et al., Nature 475, 217 (2011).