TALENs facilitate targeted genome editing in human cells with high specificity and low cytotoxicity

Nucleic Acids Research

Volumn 42, Issue 10, 2014, Pages 6762-6773

  Mussolino, Claudio ^a,b   Alzubi, Jamal ^a,b   Fine, Eli J ^c   Morbitzer, Robert ^d   Cradick, Thomas J ^c   Lahaye, Thomas ^d,e   Bao, Gang ^c   Cathomen, Toni ^a,b  

^a UNIVERSITY OF FREIBURG   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c Wallace H Coulter Department of Biomedical Engineering   (United States)

^d UNIVERSITY OF MUNICH   (Germany)

^e UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5; ENDONUCLEASE; INTERLEUKIN 2 RECEPTOR GAMMA; TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NUCLEASE; UNCLASSIFIED DRUG; ZINC FINGER NUCLEASE;

AAVS1 GENE; APOPTOSIS; ARTICLE; BIOINFORMATICS; CCR5 GENE; CELL CYCLE REGULATION; CELL LINE; CELL SURVIVAL; CELL VIABILITY; CHROMATIN STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DNA MODIFICATION; DNA SEQUENCE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME SPECIFICITY; GENE; GENE DISRUPTION; GENE EXPRESSION; GENE REARRANGEMENT; GENE TARGETING; GENETIC ENGINEERING; HUMAN; HUMAN CELL; IL2RG GENE; MUTATION RATE; NEWBORN; OFF TARGET CLEAVAGE ACTIVITY; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION;

CELLS, CULTURED; DEOXYRIBONUCLEASES; DNA CLEAVAGE; GENETIC LOCI; GENOME, HUMAN; HEK293 CELLS; HELA CELLS; HUMANS; INTERLEUKIN RECEPTOR COMMON GAMMA SUBUNIT; PROTEIN ENGINEERING; RECEPTORS, CCR5;

EID: 84903212620     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gku305     Document Type: Article

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