Multiplex genome engineering using CRISPR/Cas systems

Science

Volumn 339, Issue 6121, 2013, Pages 819-823

  Cong, Le ^a,b,c   Ran, F Ann ^a,b,d   Cox, David ^a,b,c   Lin, Shuailiang ^a,b,e   Barretto, Robert ^f   Habib, Naomi ^a,b   Hsu, Patrick D ^a,b,d   Wu, Xuebing ^g   Jiang, Wenyan ^h   Marraffini, Luciano A ^h   Zhang, Feng ^a,b  

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d HARVARD UNIVERSITY   (United States)

^e TSINGHUA UNIVERSITY   (China)

^f School of Life Sciences Tsinghua University ^*  (United States)

^g MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^h ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAS9 NUCLEASE; DNA DIRECTED RNA POLYMERASE III; NUCLEASE; RIBONUCLEASE III; RNA; UNCLASSIFIED DRUG;

ENZYME ACTIVITY; GENE EXPRESSION; GENETIC ENGINEERING; GENETIC VARIATION; GENOME; HOMINID; HOMOLOGY; MUTATION; PROKARYOTE; RODENT;

ADAPTIVE IMMUNITY; AMPLICON; ANIMAL CELL; ARTICLE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT SYSTEM; DNA CLEAVAGE; DOUBLE STRANDED DNA BREAK; GENE LOCUS; GENETIC ENGINEERING; GENETIC VARIABILITY; HETEROLOGOUS EXPRESSION; HUMAN; HUMAN CELL; INTEGRATION; MUTAGENIC ACTIVITY; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; RNA INTERFERENCE; RNA STRUCTURE;

MAMMALIA; PROKARYOTA;

EID: 84873729095     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1231143     Document Type: Article

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