In vivo genome editing using nuclease-encoding mRNA corrects SP-B deficiency

Nature Biotechnology

Volumn 33, Issue 6, 2015, Pages 584-586

  Mahiny, Azita J ^a   Dewerth, Alexander ^a   Mays, Lauren E ^a   Alkhaled, Mohammed ^a   Mothes, Benedikt ^a   Malaeksefat, Emad ^b   Loretz, Brigitta ^b   Rottenberger, Jennifer ^a   Brosch, Darina M ^a   Reautschnig, Philipp ^a   Surapolchai, Pacharapan ^a   Zeyer, Franziska ^a   Schams, Andrea ^c,d   Carevic, Melanie ^a   Bakele, Martina ^a   Griese, Matthias ^c,d   Schwab, Matthias ^a,e   Nürnberg, Bernd ^a   Beer Hammer, Sandra ^a   Handgretinger, Rupert ^a   Hartl, Dominik ^a   Lehr, Claus Michael ^b,f   Kormann, Michael S D ^a   more..

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^d German Center for Lung Research   (Germany)

^e DR MARGARETE FISCHER BOSCH INSTITUTE OF CLINICAL PHARMACOLOGY   (Germany)

^f SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DOXYCYCLINE; GENOMIC DNA; INTERLEUKIN 12; MESSENGER RNA; NANOPARTICLE; NUCLEASE; PLASMID DNA; POLYGLACTIN; SURFACTANT PROTEIN B; TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NUCLEASE; ZINC FINGER NUCLEASE; CHITOSAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; CHROMOSOME; CONTROLLED STUDY; DISEASE COURSE; DNA MODIFICATION; DNA SEQUENCE; FIBROBLAST; GENE EXPRESSION; GENOME; GENOME EDITING; HUMAN; HUMAN CELL; LETTER; LUNG ALVEOLUS CELL; LUNG COMPLIANCE; LUNG FUNCTION; MOUSE; NEUTROPHILIA; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TRANSIENT EXPRESSION; ANIMAL; ASTHMA; DEFICIENCY; DISEASE MODEL; GENETICS; PULMONARY ALVEOLAR PROTEINOSIS; RNA EDITING; TRANSGENIC MOUSE;

ANIMALS; ASTHMA; CHITOSAN; DISEASE MODELS, ANIMAL; HUMANS; MICE; MICE, TRANSGENIC; NANOPARTICLES; PULMONARY ALVEOLAR PROTEINOSIS; PULMONARY SURFACTANT-ASSOCIATED PROTEIN B; RNA EDITING; RNA, MESSENGER;

EID: 84930947142     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.3241     Document Type: Letter

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