In vivo selection of combinatorial libraries and designed affinity maturation of polydactyl zinc finger transcription factors for ICAM-1 provides new insights into gene regulation

Journal of Molecular Biology

Volumn 341, Issue 3, 2004, Pages 635-649

  Magnenat, Laurent ^a   Blancafort, Pilar ^a   Barbas III, Carlos F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

affinity maturation; designer transcription factor; ICAM 1 regulation; in vivo library selection; IRES, internal ribosome entry site; polydactyl zinc finger; TFZFs, ZF transcription factors; ZF, zinc finger; ZFPs, ZF proteins

Indexed keywords

DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; TRANSCRIPTION FACTOR; ZINC FINGER PROTEIN;

ARTICLE; BINDING AFFINITY; CANCER CELL; CELL TYPE; COMBINATORIAL LIBRARY; CONTROLLED STUDY; CORRELATION ANALYSIS; GENE; GENE INDUCTION; GENE TARGETING; GENETIC REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VIVO STUDY; INTERCELLULAR ADHESION MOLECULE 1 GENE; MAMMAL CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN ISOLATION; REGULATORY MECHANISM; SCREENING; TUMOR;

MAMMALIA;

EID: 4344685148     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2004.06.030     Document Type: Article

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