Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV

New England Journal of Medicine

Volumn 370, Issue 10, 2014, Pages 901-910

  Tebas, Pablo ^a   Stein, David ^b   Tang, Winson W ^c   Frank, Ian ^a   Wang, Shelley Q ^c   Lee, Gary ^c   Spratt, S Kaye ^c   Surosky, Richard T ^c   Giedlin, Martin A ^c   Nichol, Geoff ^c   Holmes, Michael C ^c   Gregory, Philip D ^c   Ando, Dale G ^c   Kalos, Michael ^a   Collman, Ronald G ^a   Binder Scholl, Gwendolyn ^a   Plesa, Gabriela ^a   Hwang, Wei Ting ^a   Levine, Bruce L ^a   June, Carl H ^a,d  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c SANGAMO BIOSCIENCES INC   (United States)

^d Institute for Translational Medicine and Therapeutics   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; ZINC FINGER NUCLEASE;

ADULT; ARTHRALGIA; ARTICLE; BACKACHE; CCR5 GENE; CD4 CD8 RATIO; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CELL COUNT; CHILL; CLINICAL ARTICLE; COHORT ANALYSIS; DISEASE SEVERITY; DNA END JOINING REPAIR; DRUG EFFICACY; DRUG SAFETY; ENGRAFTMENT; ETHNICITY; FEMALE; FEVER; GENE; GENE DISRUPTION; GENE EDITING; GENE LOCUS; GENETIC PROCEDURES; GENETIC RESISTANCE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; LIMIT OF DETECTION; MALE; MIDDLE AGED; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; VIRUS LOAD; VIRUS RESISTANCE;

ADULT; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; BLOOD TRANSFUSION, AUTOLOGOUS; CD4-POSITIVE T-LYMPHOCYTES; COMBINED MODALITY THERAPY; DNA, VIRAL; FEMALE; GENETIC THERAPY; HIV; HIV INFECTIONS; HUMANS; LYMPHOCYTE COUNT; LYMPHOCYTE TRANSFUSION; MALE; MIDDLE AGED; RECEPTORS, CCR5; RECTUM; RNA, VIRAL; VIRAL LOAD;

EID: 84895487305     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1300662     Document Type: Article

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