Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage

Science

Volumn 351, Issue 6275, 2016, Pages 867-871

  Jiang, Fuguo ^a   Taylor, David W ^a,b   Chen, Janice S ^a   Kornfeld, Jack E ^a   Zhou, Kaihong ^a   Thompson, Aubri J ^a   Nogales, Eva ^a,b,c   Doudna, Jennifer A ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; NUCLEASE; ENDONUCLEASE; GUIDE RNA; RNA;

BACTERIUM; DNA; ENZYME; GENETIC ENGINEERING; GENOME; IMMUNITY; PROTEIN;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONFORMATION; CRYSTAL STRUCTURE; DNA CLEAVAGE; DNA HELIX; DNA RNA HYBRIDIZATION; DNA STRAND; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN DOMAIN; PROTEIN STRUCTURE; STREPTOCOCCUS PYOGENES; CHEMISTRY; CRISPR CAS SYSTEM; ENZYME ACTIVE SITE; ENZYMOLOGY; GENETIC ENGINEERING; GENOME; PROTEIN CONFORMATION; ULTRASTRUCTURE; X RAY CRYSTALLOGRAPHY;

BACTERIA (MICROORGANISMS); STREPTOCOCCUS PYOGENES;

CATALYTIC DOMAIN; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; CRISPR-CAS SYSTEMS; CRYSTALLOGRAPHY, X-RAY; DNA; DNA CLEAVAGE; ENDONUCLEASES; GENETIC ENGINEERING; GENOME; NUCLEIC ACID CONFORMATION; PROTEIN CONFORMATION; RNA; RNA, GUIDE; STREPTOCOCCUS PYOGENES;

EID: 84958953000     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aad8282     Document Type: Article

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