Highly efficient endogenous human gene correction using designed zinc-finger nucleases

Nature

Volumn 435, Issue 7042, 2005, Pages 646-651

  Urnov, Fyodor D ^a   Miller, Jeffrey C ^a   Lee, Ya Li ^a   Beausejour, Christian M ^a   Rock, Jeremy M ^a   Augustus, Sheldon ^a   Jamieson, Andrew C ^a   Porteus, Matthew H ^b   Gregory, Philip D ^a   Holmes, Michael C ^a  

^a SANGAMO BIOSCIENCES INC   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMEDICAL ENGINEERING; CELLS; DISEASE CONTROL; DISEASES; DNA; GENES; IMMUNOLOGY; PROTEINS; RNA;

GENE THERAPY; HUMAN CELLS; SEVERE COMBINED IMMUNE DEFICIENCY (SCID); T-CELLS;

HUMAN ENGINEERING;

DNA; DOUBLE STRANDED DNA; EXTRACHROMOSOMAL DNA; GENE PRODUCT; INTERLEUKIN 2 RECEPTOR GAMMA; MESSENGER RNA; NUCLEASE; PROTEIN; RECOMBINANT PROTEIN; ZINC FINGER PROTEIN; DEOXYRIBONUCLEASE; INTERLEUKIN 2 RECEPTOR;

BIOLOGY;

ARTICLE; COMBINED IMMUNODEFICIENCY; DNA MODIFICATION; DNA REPAIR; DNA STRAND BREAKAGE; GENE; GENE CORRECTION; GENE MUTATION; GENE THERAPY; GENETIC SELECTION; GENOTYPE; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; HUMAN GENOME; IL2RGAMMA GENE; MEDICAL RESEARCH; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN ENGINEERING; T LYMPHOCYTE; X CHROMOSOME; ALLELE; CD4+ T LYMPHOCYTE; CELL CULTURE; CELL LINE; CHEMISTRY; DNA DAMAGE; ENZYME SPECIFICITY; GENE TARGETING; GENETIC LINKAGE; GENETIC RECOMBINATION; GENETICS; METABOLISM; METHODOLOGY; REPORTER GENE; SEQUENCE HOMOLOGY;

ALLELES; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; CELLS, CULTURED; CHROMOSOMES, HUMAN, X; DNA; DNA DAMAGE; DNA REPAIR; ENDODEOXYRIBONUCLEASES; GENE TARGETING; GENE THERAPY; GENES, REPORTER; HUMANS; LINKAGE (GENETICS); RECEPTORS, INTERLEUKIN-2; RECOMBINATION, GENETIC; RNA, MESSENGER; SEQUENCE HOMOLOGY, NUCLEIC ACID; SEVERE COMBINED IMMUNODEFICIENCY; SUBSTRATE SPECIFICITY; ZINC FINGERS;

EID: 18944373328     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03556     Document Type: Article

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