A split-Cas9 architecture for inducible genome editing and transcription modulation

Nature Biotechnology

Volumn 33, Issue 2, 2015, Pages 139-142

  Zetsche, Bernd ^a,b,c,d,e   Volz, Sara E ^a,b,c,d   Zhang, Feng ^a,b,c,d  

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d Massachusetts Institute of Technology Cambridge   (United States)

^e UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CRISPR ASSOCIATED ENDONUCLEASE 9; CRISPR ASSOCIATED PROTEIN; FK 506 BINDING PROTEIN; GUIDE RNA; MAMMALIAN TARGET OF RAPAMYCIN; UNCLASSIFIED DRUG; CASPASE 9;

CONTROLLED STUDY; CRYSTAL STRUCTURE; GENE TARGETING; GENETIC TRANSCRIPTION; GENOME EDITING; HUMAN; HUMAN CELL; INDEL MUTATION; LENTIVIRINAE; LETTER; MODULATION; NONHUMAN; NUCLEAR IMPORT; NUCLEAR LOCALIZATION SIGNAL; POINT MUTATION; PRIORITY JOURNAL; TRANSCRIPTION INITIATION; ANTIBODY SPECIFICITY; GENETICS; HUMAN GENOME; PROMOTER REGION; RNA EDITING;

CASPASE 9; GENOME, HUMAN; HUMANS; ORGAN SPECIFICITY; PROMOTER REGIONS, GENETIC; RNA EDITING; TRANSCRIPTION, GENETIC;

EID: 84923297110     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.3149     Document Type: Letter

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