In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy

Science

Volumn 351, Issue 6271, 2016, Pages 403-407

  Nelson, Christopher E ^a,b   Hakim, Chady H ^c   Ousterout, David G ^a,b   Thakore, Pratiksha I ^a,b   Moreb, Eirik A ^a,b   Castellanos Rivera, Ruth M ^d   Madhavan, Sarina ^a,b   Pan, Xiufang ^c   Ran, F Ann ^e,f   Yan, Winston X ^e,g,h   Asokan, Aravind ^d   Zhang, Feng ^e,i,j,k   Duan, Dongsheng ^c   Gersbach, Charles A ^a,b,l  

^a Duke University   (United States)

^b DUKE UNIVERSITY   (United States)

^c University of Missouri   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^f HARVARD UNIVERSITY   (United States)

^g HARVARD MEDICAL SCHOOL   (United States)

^h HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

ⁱ MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^j MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^k Massachusetts Institute of Technology Cambridge   (United States)

^l DUKE UNIVERSITY MEDICAL CENTER   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CRISPR ASSOCIATED PROTEIN; CRISPR ASSOCIATED PROTEIN 9; DYSTROPHIN; GENOMIC DNA; MESSENGER RNA; NEURONAL NITRIC OXIDE SYNTHASE; PARVOVIRUS VECTOR; UNCLASSIFIED DRUG;

BIOCHEMICAL COMPOSITION; GENE EXPRESSION; GENOME; MUSCLE; MUTATION; NUMERICAL MODEL; PROTEIN; RODENT; SKELETON; VIRUS;

ADULT; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL LYSATE; CONTROLLED STUDY; CRISPR CAS SYSTEM; DUCHENNE MUSCULAR DYSTROPHY; ENZYME ACTIVITY; EXON SKIPPING; GENE EXPRESSION; GENE MUTATION; GENOME EDITING; HEART MUSCLE; IMMUNOFLUORESCENCE; IN VIVO STUDY; MOUSE; MUSCLE CONTRACTILITY; MUSCLE FUNCTION; MUSCLE STRENGTH; NONHUMAN; NONSENSE MUTATION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIBIALIS ANTERIOR MUSCLE; VIRAL GENE DELIVERY SYSTEM; WESTERN BLOTTING; X CHROMOSOME LINKED MUSCULAR DYSTROPHIC MOUSE;

ADENO-ASSOCIATED VIRUS; MUS;

EID: 84963940775     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aad5143     Document Type: Article

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