Safeguarding gene drive experiments in the laboratory: Multiple stringent confinement strategies should be used whenever possible

Science

Volumn 349, Issue 6251, 2015, Pages 927-929

  Akbari, Omar S ^a   Bellen, Hugo J ^b   Bier, Ethan ^c   Bullock, Simon L ^d   Burt, Austin ^e   Church, George M ^f   Cook, Kevin R ^g   Duchek, Peter ^h   Edwards, Owain R ⁱ   Esvelt, Kevin M ^f   Gantz, Valentino M ^c   Golic, Kent G ^j   Gratz, Scott J ^k   Harrison, Melissa M ^l   Hayes, Keith R ⁱ   James, Anthony A ^m   Kaufman, Thomas C ^g   Knoblich, Juergen ^h   Malik, Harmit S ^n,o   Matthews, Kathy A ^g   O'Connor Giles, Kate M ^k   Parks, Annette L ^g   Perrimon, Norbert ^f,o   Port, Fillip ^d   Russell, Steven ^p   Ueda, Ryu ^q,r   Wildonger, Jill ^k   more..

^a UNIVERSITY OF CALIFORNIA   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c SECTION OF CELL AND DEVELOPMENTAL BIOLOGY   (United States)

^d MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^e IMPERIAL COLLEGE LONDON   (United Kingdom)

^f HARVARD MEDICAL SCHOOL   (United States)

^g INDIANA UNIVERSITY   (United States)

^h ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

ⁱ CSIRO   (Australia)

^j UNIVERSITY OF UTAH   (United States)

^k UNIVERSITY OF WISCONSIN MADISON   (United States)

^l UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^m UNIVERSITY OF CALIFORNIA   (United States)

ⁿ Fred Hutchinson Cancer Research Center   (United States)

^o HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^p UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^q GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

^r NATIONAL INSTITUTE OF GENETICS   (Japan)

more..

Author keywords

[No Author keywords available]

Indexed keywords

GUIDE RNA; ENDONUCLEASE;

EXPERIMENTAL STUDY; GENE EXPRESSION; LABORATORY METHOD; MUTATION; RNA;

BIOSAFETY; CLINICAL LABORATORY; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; DROSOPHILA MELANOGASTER; GENE DRIVE; GENOME; HOMOZYGOTE; MEDICAL RESEARCH; MOLECULAR GENETICS; MUTANT DROSOPHILA; NONHUMAN; POPULATION DYNAMICS; PRACTICE GUIDELINE; PRIORITY JOURNAL; REVIEW; RNA SPLICING; SEGREGATION DISTORTION; SUSTAINABLE AGRICULTURE; ANIMAL; CRISPR CAS SYSTEM; GENETIC ENGINEERING; GENETICS; HAZARDOUS WASTE; METABOLISM; SAFETY; TRANSGENIC ORGANISM;

ANIMALS; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; CONTAINMENT OF BIOHAZARDS; CRISPR-CAS SYSTEMS; ENDONUCLEASES; GENETIC ENGINEERING; GENETIC RESEARCH; GENOME; ORGANISMS, GENETICALLY MODIFIED; SAFETY;

EID: 84940502877     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aac7932     Document Type: Review

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