Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease

Nature

Volumn 513, Issue 7519, 2014, Pages 569-573

  Anders, Carolin ^a   Niewoehner, Ole ^a   Duerst, Alessia ^a   Jinek, Martin ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; CAS9 ENZYME; DNA; ENDONUCLEASE; RNA; UNCLASSIFIED DRUG; ARGININE; CRISPR ASSOCIATED PROTEIN; GUIDE RNA;

AMINO ACID; BACTERIUM; CRYSTAL STRUCTURE; DNA; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC ENGINEERING; GENOME; MOLECULAR ANALYSIS; PROTEIN; RECOGNITION; RNA;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; DNA DENATURATION; DNA RNA HYBRIDIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF; PROTOSPACER ADJACENT MOTIF; STREPTOCOCCUS PYOGENES; BASE PAIRING; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; METABOLISM; NUCLEOTIDE MOTIF; NUCLEOTIDE SEQUENCE; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

STREPTOCOCCUS PYOGENES;

ARGININE; BASE PAIRING; BASE SEQUENCE; CRISPR-ASSOCIATED PROTEINS; CRYSTALLOGRAPHY, X-RAY; DNA; ENDONUCLEASES; MODELS, MOLECULAR; NUCLEIC ACID DENATURATION; NUCLEOTIDE MOTIFS; PROTEIN CONFORMATION; RNA, GUIDE; STREPTOCOCCUS PYOGENES; SUBSTRATE SPECIFICITY;

EID: 84908508061     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature13579     Document Type: Article

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